Ultrasound Cavitation/Microbubble Detection and Medical Applications

Izadifar, Zohreh; Babyn, Paul; Chapman, Dean

doi:10.1007/s40846-018-0391-0

Cited by 87 publications

(66 citation statements)

References 119 publications

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“…In this study, the suspensions of live slime mold amoebae were exposed to ultrasound and treated with fluorescein-labeled dextran, normally impermeable to cells of its size. There was 40% increase in fluorophore uptake by the ultrasound treated cells and the concept subsequently was translated in mammalian cells for delivering DNA (Fechheimer et al, 1987; Izadifar et al, 2019).…”

Section: Biophysical Effects Of Ultrasounds On Cellsmentioning

confidence: 99%

“…Also, the MI gives an exact estimation of the produced cavitation, greater MI values induce greater cavitation activity. To circumvent undesirable thermal adverse effects in the course of ultrasound treatment, the MI in the range of 0.2 and 1.9 is used, and the FDA has a recommendation of the higher limit of the MI to 1.9 for clinical use of ultrasound to bypass direct tissue harm by ultrasound (Izadifar et al, 2019).…”

Section: Ultrasound Parametersmentioning

confidence: 99%

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Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Tharkar

Varanasi

Wong

et al. 2019

Front. Bioeng. Biotechnol.

148

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While ultrasound is most widely known for its use in diagnostic imaging, the energy carried by ultrasound waves can be utilized to influence cell function and drug delivery. Consequently, our ability to use ultrasound energy at a given intensity unlocks the opportunity to use the ultrasound for therapeutic applications. Indeed, in the last decade ultrasound-based therapies have emerged with promising treatment modalities for several medical conditions. More recently, ultrasound in combination with nanomedicines, i.e., nanoparticles, has been shown to have substantial potential to enhance the efficacy of many treatments including cancer, Alzheimer disease or osteoarthritis. The concept of ultrasound combined with drug delivery is still in its infancy and more research is needed to unfold the mechanisms and interactions of ultrasound with different nanoparticles types and with various cell types. Here we present the state-of-art in ultrasound and ultrasound-assisted drug delivery with a particular focus on cancer treatments. Notably, this review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions. Furthermore, this review presents safety considerations related to ultrasound technology and gives recommendations in the context of system design and operation.

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Section: Biophysical Effects Of Ultrasounds On Cellsmentioning

confidence: 99%

Section: Ultrasound Parametersmentioning

confidence: 99%

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Tharkar

Varanasi

Wong

et al. 2019

Front. Bioeng. Biotechnol.

148

View full text Add to dashboard Cite

show abstract

“…However, the membrane that functions as a physical boundary triggers the collapsed of the cavitation bubbles asymmetrically once it hits the solid surface. The collapsion of the bubble was reported to create h igh-speed liquid jet driv ing onto the memb rane of the tissue [25]. This occurrence consequently leads to membrane disruption and allows easy permeation of detergent solut ion to comp letely decellularize the tissue.…”

Section: Discussionmentioning

confidence: 99%

Engineered Meniscus Scaffolds using Sonication Decellularization Treatment System

Yusof

Sha'ban

Azhim

2019

IJIE

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“…Afterwards, the pellicles were immersed in ammonium hydroxide (NH 4 OH) solution and ultrasonicated [ 55 ]. Cavitation, which consists in the generation and collapse of microbubbles, occurs under the influence of ultrasonic waves and produces elevated pressure and temperature [ 58 ] that favors the formation of ZnO NPs. The impregnation time and ultrasonic treatment duration had a significant effect on the size and incorporation percentage of ZnO into BC—a higher impregnation time led to an increased amount of ZnO NPs into the pellicles and a longer ultrasonic treatment resulted in smaller crystal size (54–63 nm) [ 55 ].…”

Section: Antibacterial Nanocellulose-metal Oxides Hybridsmentioning

confidence: 99%

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Oprea

Panaitescu

2020

Molecules

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Cellulose is one of the most affordable, sustainable and renewable resources, and has attracted much attention especially in the form of nanocellulose. Bacterial cellulose, cellulose nanocrystals or nanofibers may serve as a polymer support to enhance the effectiveness of metal nanoparticles. The resultant hybrids are valuable materials for biomedical applications due to the novel optical, electronic, magnetic and antibacterial properties. In the present review, the preparation methods, properties and application of nanocellulose hybrids with different metal oxides nanoparticles such as zinc oxide, titanium dioxide, copper oxide, magnesium oxide or magnetite are thoroughly discussed. Nanocellulose-metal oxides antibacterial formulations are preferred to antibiotics due to the lack of microbial resistance, which is the main cause for the antibiotics failure to cure infections. Metal oxide nanoparticles may be separately synthesized and added to nanocellulose (ex situ processes) or they can be synthesized using nanocellulose as a template (in situ processes). In the latter case, the precursor is trapped inside the nanocellulose network and then reduced to the metal oxide. The influence of the synthesis methods and conditions on the thermal and mechanical properties, along with the bactericidal and cytotoxicity responses of nanocellulose-metal oxides hybrids were mainly analyzed in this review. The current status of research in the field and future perspectives were also signaled.

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Ultrasound Cavitation/Microbubble Detection and Medical Applications

Cited by 87 publications

References 119 publications

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Engineered Meniscus Scaffolds using Sonication Decellularization Treatment System

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

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