Engineered Meniscus Scaffolds using Sonication Decellularization Treatment System

Knee meniscus is the cushioning fibro-cartilage tissue present in between the femoral condyles and tibial plateau of knee joint. It is largely avascular in nature and suffers from a wide range of tears and injuries caused by accidents, trauma, active lifestyle of the populace and old age of individuals. Healing of meniscus is especially difficult due to their avascularity and hence requires invasive arthroscopic approaches such as surgical resection, suturing or implantation. Though various tissue engineering approaches are proposed for treatment of meniscus tears, 3D printing/bioprinting, injectable hydrogels and physical stimulation involving modalities are gaining forefront in the past decade. A plethora of new printing approaches such as direct light photopolymerization and volumetric printing, injectable biomaterials loaded with growth factors and physical stimulation such as low intensity ultrasound approaches are being added to the treatment portfolio along with the contemporary tear mitigation measures. This review discusses on the necessary design considerations, approaches for 3D modeling and design practices for meniscal tear treatments within the scope of tissue engineering and regeneration. Also, the suitable materials, cell sources, growth factors, mechanical stimulation approaches, 3D printing strategies and injectable hydrogels for meniscal tear management have been elaborated. We have also summarized potential technologies and the potential framework that could be the herald of future of meniscus tissue engineering and repair approaches.

show abstract

Engineered Meniscus Scaffolds using Sonication Decellularization Treatment System

Cited by 2 publications

References 30 publications

Hybrid Bioscaffolds Formation Using Natural and Synthetic Materials for Cartilage Tissue Engineering: The Case of Fibrin, Atelocollagen and Poly(Lactic-co-Glycolic Acid)

Hybrid Bioscaffolds Formation Using Natural and Synthetic Materials for Cartilage Tissue Engineering: The Case of Fibrin, Atelocollagen and Poly(Lactic-co-Glycolic Acid)

Current advances in engineering meniscal tissues: insights into 3D printing, injectable hydrogels and physical stimulation based strategies

Contact Info

Product

Resources

About