Ultrasound-assisted preparation of novel ibuprofen-loaded excipient with improved compression and dissolution properties

Gandhi, Paras; Patil, Sharvil; Aher, Suyog; Paradkar, Anant

doi:10.3109/03639045.2016.1151035

Cited by 13 publications

(3 citation statements)

References 31 publications

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“…Na literatura existem relatos da formação de diferentes cristais de ibuprofeno para utilização em compressão direta (NOKHODCHI et al, 2010). O hábito cristalino tipo placa (obtido através da técnica de sono cristalização anti-solvente) mostrou melhora significativa para a compressão direta e dissolução do fármaco, mas com um aspecto negativo em relação à dureza do comprimido, sendo recomendado o uso de um desintegrante, como o amido, na formulação (GANDHI et al, 2016).…”

Section: Figura 2 -Perfil De Dissolução Dos Medicamentos Analisadosunclassified

Equivalência Farmacêutica e Perfil de Dissolução de Comprimidos de Ibuprofeno Comercializados em Fortaleza

Floriano

Oliveira

2022

Ensaios Ciênc.

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Os anti-inflamatórios não esteroidais (AINEs) constituem um grupo terapêutico de interesse, pois têm propriedades analgésicas, antipiréticas e anti-inflamatórias, sendo uma das classes mais consumidas no mundo. No Brasil, os AINEs são facilmente encontrados em farmácias e alguns são comercializados sem a apresentação do receituário, sendo que o Ibuprofeno é o fármaco de primeira escolha entre os AINES. A qualidade e a intercambialidade de diferentes medicamentos é garantida pela comprovação da equivalência farmacêutica, bioequivalência, boas práticas de fabricação e controle de qualidade na indústria farmacêutica. O presente trabalho teve por objetivo realizar a equivalência farmacêutica e perfil de dissolução de comprimidos de ibuprofeno 600 mg (referência, genérico e similar) comercializados em Fortaleza, com o intuito de avaliar a qualidade dos medicamentos similares e genéricos em relação ao medicamento de referência. Para as análises foram utilizados o medicamento referência, um medicamento genérico e quatro similares. As análises realizadas foram determinação de peso, dureza, friabilidade, teste de desintegração, uniformidade de dose unitária, teste de dissolução, doseamento e testes de segurança biológica de acordo com a Farmacopeia Brasileira 6ª Edição, bem como o perfil de dissolução comparativo. Os comprimidos analisados estavam dentro da especificação para todos os testes físico-químicos e microbiológicos realizados. Contudo, em relação ao perfil de dissolução, somente um medicamento similar foi semelhante ao medicamento referência analisado nas condições de ensaio in vitro empregadas, sendo equivalente farmacêutico ao de referência. Palavras-chave: Ibuprofeno. Equivalência Farmacêutica. Controle de Qualidade. Medicamentos Genéricos. Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are a therapeutic group of interest, as they have analgesic, antipyretic and anti-inflammatory properties, being one of the most consumed classes in the world. In Brazil, NSAIDs are easily found in pharmacies and some are sold without prescriptions and Ibuprofen is the drug of first choice among NSAIDs. The quality and interchangeability of different drugs are guaranteed by proof of pharmaceutical equivalence, bioequivalence, good manufacturing practices and quality control in the pharmaceutical industry. This study aimed to carry out the pharmaceutical equivalence and dissolution profile of ibuprofen tablets 600 mg (reference, generic and similar) commercialized in Fortaleza, in order to assess the quality of similar and generic drugs in relation to the reference drug. For the analyses, the reference drug, a generic drug and four similar drugs were used. The analyzes performed were determination of weight, hardness, friability, disintegration test, uniformity of unit dose, dissolution test, dosage and biological safety tests according to the Brazilian Pharmacopoeia 6th Edition, as well as the comparative dissolution profile. The tablets analyzed were within the specification for all the physical-chemical and microbiological tests performed. However, in relation to the dissolution profile, only one similar drug was similar to the analyzed reference drug under the in vitro test conditions used, being pharmaceutical equivalent to the reference drug. Keywords: Ibuprofen. Pharmaceutical equivalence. Quality control. Generic Drugs.

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Section: Figura 2 -Perfil De Dissolução Dos Medicamentos Analisadosunclassified

Equivalência Farmacêutica e Perfil de Dissolução de Comprimidos de Ibuprofeno Comercializados em Fortaleza

Floriano

Oliveira

2022

Ensaios Ciênc.

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“…Palanisamy, et al [24]. Capping and sticking problem were minimized by adding 0.5% of lubricant in formulation of effervescent tablets [25].…”

Section: Effervescent Mouthwash Formulationmentioning

confidence: 99%

Comprehensive Review on Ficus Deltoidea Effervescent Mouthwash Formulation in Treating Oral Pathogens

Chitalia¹,

Senthil²,

Jun³

et al. 2021

IJHMS

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Ficus deltoidea or its well-known local name Mas Cotek belongs to the family of Moracaeae. This native plant is commonly found in Malaysia, other tropical and subtropical countries. Oral periodontal disease is an alarming disease and the utilization of herbal plants in treating oral pathogens has raised attention and concern. Therefore the main objective of this study was to review the effectiveness of effervescent mouthwash formulation of the FDL on treating oral pathogens. Plaque accumulation and oral microorganisms are the main predisposing factors to oral periodontal diseases. Herbal mouthwash has been of particular interest these days to treat oral pathogens. Different effervescent agents such as citric acid, tartaric acid, and sodium bicarbonate were used in formulating effervescent mouthwash by different methods with varying concentrations. FDL leaves have claimed to possess different properties such as antioxidant, anti-diabetic, and anti-inflammatory properties which are helpful in treating many diseases. Post compression parameters such as effervescent time, moisture content, and in vitro antibacterial test were reviewed in this study. FDL has shown a strong correlation to the presence of high content of polyphenols, flavonoids, saponin, tannins, and triterpenoids. In conclusion, the type of preparation choosen is by using wet granulation method and the suitable ratio is 2:1.

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“…NTDs affect one-sixth of the world's population including parasitic diseases such as leishmaniasis, Chagas disease, human African trypanosomiasis, lymphatic filariasis, onchocerciasis and Guinea worm disease. Overall, NDTs lead to retardation of children growth, impairment of cognitive skills, lost ability to attend school or work and a serious economic burden placed on entire countries [3,4].…”

Section: Introductionmentioning

confidence: 99%

Applying Loop-mediated Isothermal Amplification (LAMP) in the Diagnosis of Malaria, Leishmaniasis and Trypanosomiasis as Point-of-Care Tests (POCTs)

Dea-Ayuela

Galiana‐Roselló

Lalatsa

et al. 2018

CTMC

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One of the main objectives of the WHO is controlling transmission of parasitic protozoa vector-borne diseases. A quick and precise diagnosis is critical in selecting the optimal therapeutic regime that avoids unnecessary treatments and the emergence of resistance. Molecular assays based on loopmediated isothermal amplification (LAMP) techniques are a good alternative to light microscopy and antigen-based rapid diagnostic tests in developing countries, since they allow for a large amount of genetic material generated from a few copies of DNA, and use primers that lead to high sensitivity and specificity, while the amplification process can be performed in isothermal conditions without the need of sophisticated equipment to interpret the results. In this review, the main advances in the development of LAMP assays for the diagnosis of malaria, leishmaniasis and Chagas' disease are discussed as well as the feasibility of their implementation in developing countries and use as point-of-care diagnostic tests.

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Ultrasound-assisted preparation of novel ibuprofen-loaded excipient with improved compression and dissolution properties

Abstract: Directly compressible ibuprofen-loaded DCP particles can serve as an alternative for conventional ibuprofen tablets prepared by wet granulation technique.

Cited by 13 publications

References 31 publications

Equivalência Farmacêutica e Perfil de Dissolução de Comprimidos de Ibuprofeno Comercializados em Fortaleza

Equivalência Farmacêutica e Perfil de Dissolução de Comprimidos de Ibuprofeno Comercializados em Fortaleza

Comprehensive Review on Ficus Deltoidea Effervescent Mouthwash Formulation in Treating Oral Pathogens

Applying Loop-mediated Isothermal Amplification (LAMP) in the Diagnosis of Malaria, Leishmaniasis and Trypanosomiasis as Point-of-Care Tests (POCTs)

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