Ultrasound-assisted extraction of phlorotannins and polysaccharides from Silvetia compressa (Phaeophyceae)

Vázquez-Rodríguez, Benjamín; Gutiérrez‐Uribe, Janet A.; Antunes‐Ricardo, Marilena; Santos-Zea, Liliana; Cruz‐Suárez, Lucía Elizabeth

doi:10.1007/s10811-019-02013-2

Cited by 44 publications

(27 citation statements)

References 77 publications

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“…[ 165 , 166 ]. To maximize the extraction of phlorotannins from seaweeds, nonconventional extraction techniques such as MAE [ 171 ], UAE [ 172 ] and PLE [ 167 ] have been used. After extraction, their purification can be performed by a clean-up with Sephadex LH-20 size-exclusion chromatography and by high-speed counter-current chromatography (HSCCC) using a solvent system of n-hexane/ethyl acetate/methanol/water (2:8:3:7, v / v / v / v ) [ 168 ].…”

Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

“…After extraction, their purification can be performed by a clean-up with Sephadex LH-20 size-exclusion chromatography and by high-speed counter-current chromatography (HSCCC) using a solvent system of n-hexane/ethyl acetate/methanol/water (2:8:3:7, v / v / v / v ) [ 168 ]. Using all these conditions, phlorotannin yields in seaweeds ranged from 0.3 to 6.36% [ 165 , 166 , 167 , 168 , 171 , 172 ].…”

Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

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Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.

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Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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“…Dang et al [ 57 ] also optimized the UAE of phenolic compounds from brown seaweed Hormosira banksii , using response surface methodology, and reported that the optimum conditions for maximum phenolic content were temperature, 30 °C; time, 60 min; and power, 150 W. According to this study, the application of UAE at the optimal conditions increased the yield of TPC by 143%, as compared to the conventional extraction method. In another study, Vázquez-Rodríguez et al [ 58 ] optimized the extraction parameters, namely, extraction temperature (50–65 °C), ultrasound power density (1.2–3.8 W cL −1 ), solvent/seaweed ratio (10–30 mL g −1 ), and ethanol concentration (25–100% ethanol in water), to recover phlorotannins from brown seaweed Silvetia compressa . They reported a maximum of 7.3 mg PGE/g dry seaweed at (X1 = 50 °C, X2 = 3.8 W cL −1 , X3 = 30 mL g −1 seaweed meal, and X4 = 32.3%).…”

Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

2020

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Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applications in, e.g., food, cosmetics, and pharmaceutical industries. To survive in a very harsh and challenging environment, marine organisms like several seaweed (macroalgae) species produce and accumulate several secondary metabolites, including marine phenolics in the cells. Traditionally, these compounds were extracted from their sample matrix using organic solvents. This conventional extraction method had several drawbacks such as a long extraction time, low extraction yield, co-extraction of other compounds, and usage of a huge volume of one or more organic solvents, which consequently results in environmental pollution. To mitigate these drawbacks, newly emerging technologies, such as enzyme-assisted extraction (EAE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and supercritical fluid extraction (SFE) have received huge interest from researchers around the world. Therefore, in this review, the most recent and emerging technologies are discussed for the extraction of marine phenolic compounds of interest for their antioxidant and other bioactivity in, e.g., cosmetic and food industry. Moreover, the opportunities and the bottleneck for upscaling of these technologies are also presented.

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“…Likewise, eckols with additional hydroxyl groups are known as carmalols [4]. The procedures used for phlorotannins extraction are widely variable and include aqueous mixtures of methanol, ethanol, acetone, and more recently deep eutectic solvents, as well as different extraction techniques including microwave, ultrasounds, enzymes, pressurized liquids and others [5][6][7][8][9][10][11]. Acetone is believed to inhibit the interactions occurring between phlorotannins and proteins, breaking the hydrogen bonds between phlorotannin-protein complexes during extraction, causing an increase in the total yield of extraction [12].…”

Section: Introductionmentioning

confidence: 99%

Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway

Catarino

Silva

Cruz

et al. 2020

IJMS

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Due to their large spectrum of bioactive properties, much attention has recently been drawn to phlorotannins—i.e., phenolic compounds characteristic from brown macroalgae. This study aimed to evaluate the antioxidant and anti-inflammatory properties of F. vesiculosus phlorotannin extracts and purified fractions. Overall, the crude extract and its ethyl acetate fraction (EtOAc) showed good radical scavenging activity, particularly towards nitric oxide (NO•). Subsequent subfractions of EtOAc (F1 to F9) with different molecular weights were then shown to inhibit lipopolysaccharide-induced NO• production in macrophages, with stronger effects being observed for fractions of lower MWs. Of the three intracellular markers analyzed, inducible NO• synthase showed the highest sensitivity to almost all the phlorotannin-rich samples, followed by interleukin 1β and cyclooxygenase 2, which was only inhibited by F2. Furthermore, this subfraction inhibited the phosphorylation and degradation of inhibitory protein κBα, thus preventing the activation of NF-κB and blocking the inflammatory cascade at the transcriptional level. This sample was characterized by the presence of a major compound with a deprotonated molecular ion at m/z 507 with a fragmentation pattern coherent with that of a phlorotannin derivative. Overall, this work unveiled some of the mechanistic aspects behind the anti-inflammatory capacity of phlorotannins from F. vesiculosus, endorsing its use as a possible natural source of anti-inflammatory compounds.

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Ultrasound-assisted extraction of phlorotannins and polysaccharides from Silvetia compressa (Phaeophyceae)

Cited by 44 publications

References 77 publications

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway

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