Ultrasound-assisted extraction of bioactive alkaloids from <i>Phellodendri amurensis</i> cortex using deep eutectic solvent aqueous solutions

Li, Yuanbin; Pan, Zuchen; Wang, Binshen; Song, Siwei; Feng, Huanhuan; Zhao, Weiwei; Zhang, Jiaheng

doi:10.1039/d0nj00877j

Cited by 17 publications

(15 citation statements)

References 46 publications

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“…Adjusting the appropriate molar ratio and under the action of ultrasound, the three active compounds can be better extracted into DESs and the components with large polarity difference can be reduced. In addition, DESs probably could dissolve and hydrolyze cellulose, resulting in destruction of the cell walls [ 30 ]. Thus, higher amounts of the target compounds were exposed to the extraction solution.…”

Section: Resultsmentioning

confidence: 99%

“…They were recognized as a promising solvent in extraction and separation processes [ 23 ]. Until now, DESs have been widely used in the extraction of bioactive compounds in Chinese herbal medicine, such as polyphenols [ 24 , 25 , 26 ], flavonoids [ 27 , 28 ] and alkaloids [ 29 , 30 ]. DESs are mostly hydrophilic, and hydrophobic DESs were first reported in 2015 [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Cai

et al. 2021

Molecules

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Deep eutectic solvents (DESs) are considered as efficient and green solvents for the extraction of bioactive compounds from medicinal plants. In this work, a novel method of DES-based ultrasound-assisted extraction of bioactive compounds from Baphicacanthus cusia leaves (BCL) was established. Systematic screening and the morphology of the original and treated BCL were observed with scanning electron microscopy to determine the extraction efficiency of different solvents. The extraction conditions were optimized by Box–Behnken design (BBD) tests and the optimal extraction conditions were as follows: lactic acid/L-menthol ratio of 5: 2 (mol/mol), solid–liquid ratio of 80.0 mL/g and temperature of 60.5 °C. The extraction yields of tryptanthrin, indigo and indirubin reached 0.356, 1.744 and 0.562 mg/g, respectively. The results of a 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity test indicated the feasibility of DESs in the extraction of bioactive compounds. This study indicated that L-menthol/lactic acid was a green and efficient solvent for the extraction of bioactive compounds from BCL, and DES-based ultrasound-assisted extraction could be used as an effective application strategy for the extraction of bioactive compounds from medicinal plants.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Cai

et al. 2021

Molecules

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“…Adjacent pores are loosely arranged, and more irregular fragments were evident. These findings clearly indicate that DESs breaks down cellulose in the cell wall [ 52 ]. Accordingly, we propose the degree of rupture of AS cells is positively correlated with the extraction rate of total flavonoids, consistent with the measurement result of extraction rate.…”

Section: Resultsmentioning

confidence: 98%

A Green Method of Extracting and Recovering Flavonoids from Acanthopanax senticosus Using Deep Eutectic Solvents

Zhang

Chu

et al. 2022

Molecules

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In recent years, green extraction of bioactive compounds from herbal medicines has generated widespread interest. Deep eutectic solvents (DES) have widely replaced traditional organic solvents in the extraction process. In this study, the efficiencies of eight DESs in extracting flavonoids from Acanthopanax senticosus (AS) were compared. Response surface methodology (RSM) was employed to optimize the independent variable including ultrasonic power, water content, solid-liquid ratio, extraction temperature, and extraction time. DES composed of glycerol and levulinic acid (1:1) was chosen as the most suitable extraction medium. Optimal conditions were ultrasonic power of 500 W, water content of 28%, solid-liquid ratio of 1:18 g·mL−1, extraction temperature of 55 °C, and extraction time of 73 min. The extraction yield of total flavonoids reached 23.928 ± 0.071 mg·g−1, which was 40.7% higher compared with ultrasonic-assisted ethanol extraction. Macroporous resin (D-101, HPD-600, S-8 and AB-8) was used to recover flavonoids from extracts. The AB-8 resin showed higher adsorption/desorption performance, with a recovery rate of total flavonoids of up to 71.56 ± 0.256%. In addition, DES solvent could efficiently be reused twice. In summary, ultrasonic-assisted DES combined with the macroporous resin enrichment method is exceptionally effective in recovering flavonoids from AS, and provides a promising environmentally friendly and recyclable strategy for flavonoid extraction from natural plant sources.

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“…In Table 6 are shown various types of bioactive compounds along with their sources, which are extracted using DESs, as mentioned [137][138][139][140][141][142][143][144][145][146][147][148][149][150][151][152].…”

Section: Extraction Of Biomoleculesmentioning

confidence: 99%

“…Total phenol [146][147][148][149] Roselle (Hibiscus sabdariffa L.), Alkanet root (Alkanna tinctoria), Chickpea (Cicer arietinum L.) sprouts Total phenol, total flavonoid [150][151][152] Improving the extraction process is needed to recover the maximum content of bioactive compounds; in this regard, various advanced technologies have been employed [135,136]. Ultrasound-assisted extraction (UAE), pressurized-liquid extraction (PLE), microwaveassisted extraction (MAE), ultrasound-microwave-assisted extraction (UMAE), homogenateassisted extraction (HAE), and pulse-ultrasound-assisted extraction (PUAE) are some of the extraction techniques employed for improving the extraction process using NADES as a solvent system [136].…”

Section: Natural Sourcementioning

confidence: 99%

Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents

2022

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Recently, deep eutectic solvent (DES) or ionic liquid (IL) analogues have been considered as the newest green solvent, demonstrating the potential to replace harsh volatile organic solvents. DESs are mainly a combination of two compounds: hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD), which have the ability to interact through extensive hydrogen bonds. A thorough understanding of their physicochemical properties is essential, given their successful applications on an industrial scale. The appropriate blend of HBA to HBD can easily fine-tune DES properties for desired applications. In this context, we have reviewed the basic information related to DESs, the two most studied physicochemical properties (density and viscosity), and their performance as a solvent in (i) drug delivery and (ii) extraction of biomolecules. A broader approach of various factors affecting their performance has been considered, giving a detailed picture of the current status of DESs in research and development.

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Ultrasound-assisted extraction of bioactive alkaloids from Phellodendri amurensis cortex using deep eutectic solvent aqueous solutions

Abstract: ChCl/citric acid-based DESs are demonstrated to be effective green solvents for the ultrasound-assisted extraction of bioactive alkaloids from herbs.

Cited by 17 publications

References 46 publications

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

A Green Method of Extracting and Recovering Flavonoids from Acanthopanax senticosus Using Deep Eutectic Solvents

Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents

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