Ultrasound-assisted exfoliation of a layered 2D coordination polymer with HER electrocatalytic activity

Contreras-Pereda, Noemí; Moghzi, Faezeh; Baselga, Javier; Zhong, Haixia; Janczak, Jan; Soleimannejad, Janet; Dong, Renhao; Ruiz‐Molina, Daniel

doi:10.1016/j.ultsonch.2020.105292

Cited by 19 publications

(15 citation statements)

References 36 publications

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“…Engineering nanoscale metal coordination‐based porphyrin nanostructures with intrinsic biodegradability, facile structural and composition tunability, and most importantly, multiple therapeutic modalities are still far from being achieved. [ 42–44 ]…”

Section: Introductionmentioning

confidence: 99%

“…Engineering nanoscale metal coordination-based porphyrin nanostructures with intrinsic biodegradability, facile structural and composition tunability, and most importantly, multiple therapeutic modalities are still far from being achieved. [42][43][44] Here, we design new and facile Pd-single-atom coordinated porphyrin-based polymeric networks as biocatalysts, namely, Pd-Pta/Por, for chem-/sono-/photo-trimodal tumor therapies. Facilitated by the Pd-coordination-driven self-assembly with the pyridine N outside of organic porphyrin ligand, a nanosized Pd-Pta/Por biocatalyst can be synthesized.…”

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confidence: 99%

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Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

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clinical cancer treatments. [1] Though some conventional methods, such as surgery, radiotherapy, and chemotherapy, have been used to treat malignant melanoma in clinics, these methods have exhibited limited treatment efficiencies in inhibiting tumor growth, leading to low patient survival rates. Therefore, more creative and efficient ways are urgently needed to overcome these clinical bottlenecks; for instance, gene therapy, photodynamic therapy (PDT), photothermal therapy, sonodynamic therapy (SDT), and immunotherapy. [2][3][4][5][6] However, due to the diversity, complexity, and heterogeneity of the MM tumor, [7] mono-modal therapy has been found to show limited treatment efficiency for MM tumors. Consequently, searching for integrated therapeutic strategies with multi-modal therapeutics is highly necessary to achieve remarkable antitumor effects. [8][9][10][11][12] The SDT and PDT have been selected as potential clinical methods for treating a wide range of superficial and localized tumors. They utilize the sono-irradiation or photoexcitation to generate highly reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and hydroxyl radicals (•OH). [13][14][15][16][17] Owing to the temporal and spatial management over the localization of the sound or light, the ROS can be generated precisely in the tumor tissues instead of normal tissue, thus minimizing the side effects. [18][19][20] The unique quantity of deep tissue penetration and little side The diversity, complexity, and heterogeneity of malignant tumor seriously undermine the efficiency of mono-modal treatment. Recently, multi-modal therapeutics with enhanced antitumor efficiencies have attracted increasing attention. However, designing a nanotherapeutic platform with uniform morphology in nanoscale that integrates with efficient chem-/sono-/phototrimodal tumor therapies is still a great challenge. Here, new and facile Pd-single-atom coordinated porphyrin-based polymeric networks as biocatalysts, namely, Pd-Pta/Por, for chem-/sono-/photo-trimodal tumor therapies are designed. The atomic morphology and chemical structure analysis prove that the biocatalyst consists of atomic Pd-N coordination networks with a Pd-N 2 -Cl 2 catalytic center. The characterization of peroxidase-like catalytic activities displays that the Pd-Pta/Por can generate abundant •OH radicals for chemodynamic therapies. The ultrasound irradiation or laser excitation can significantly boost the catalytic production of 1 O 2 by the porphyrin-based sono-/photosensitizers to achieve combined sono-/photodynamic therapies. The superior catalytic production of •OH is further verified by density functional theory calculation. Finally, the corresponding in vitro and in vivo experiments have demonstrated their synergistic chem-/sono-/photo-trimodal antitumor efficacies. It is believed that this study provides new promising single-atom-coordinated polymeric networks with highly efficient biocatalytic sites and synergistic trimodal therapeutic effects, which may inspire many new findings in rea...

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

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“…Similar to other 2D materials preparation, both top-down exfoliation and bottom-up assembly can be adopted to synthesis 2D MOF nanosheets [24] . Especially, “top-down” approaches, for example, liquid-phase sonication exfoliation [25] , [26] , ball-milling [27] , [28] and chemical intercalation [29] , are readily achieved and scalable production pathway. Solvent-mediated sonication exfoliation of bulk layered MOFs into 2D nanosheet is very attractive for its general applicability and accessibility.…”

Section: Introductionmentioning

confidence: 99%

High-efficient liquid exfoliation of 2D metal-organic framework using deep-eutectic solvents

Sang

Liu

Song

et al. 2021

Ultrasonics Sonochemistry

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“…Another emerging area where sonochemistry is pushing the limits of miniaturization is that of metal–organic framework nanosheet (MONs). Two-dimensional CPs, commonly known as flakes [19] with enhanced charge transfer between electrolyte and catalysts interface [18] , [19] among other applications [20] , [21] , [22] can be obtained following the top-down liquid-phase exfoliation (LPE) approach. This approach consists on the delamination of the bulk material in the presence of specific solvents, which intercalate between the layers [23] , [24] usually assisted with ultrasound (US) [25] .…”

Section: Introductionmentioning

confidence: 99%

“…For this, the selection of the solvent is important as suitable polarities will provide stable colloidal suspensions, while some solvents can also decompose or fragment the bulk material, without obtaining layers [26] . Therefore, specific studies have been devoted to determining the role of solvent and US along the delamination process of 2D-CPs [19] , [27] . However, there is still a lot of effort to be done given the incipient nature of the field.…”

Section: Introductionmentioning

confidence: 99%

Solvent-tuned ultrasonic synthesis of 2D coordination polymer nanostructures and flakes

Pepió

Contreras-Pereda

Suárez-García

et al. 2021

Ultrasonics Sonochemistry

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Ultrasound-assisted exfoliation of a layered 2D coordination polymer with HER electrocatalytic activity

Cited by 19 publications

References 36 publications

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

High-efficient liquid exfoliation of 2D metal-organic framework using deep-eutectic solvents

Solvent-tuned ultrasonic synthesis of 2D coordination polymer nanostructures and flakes

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