Ultrasound assisted enzymatic hydrolysis for isolating titanium dioxide nanoparticles from bivalve mollusk before sp-ICP-MS

Taboada-López, María Vanesa; Iglesias-López, Sara; Herbello-Hermelo, Paloma; Bermejo–Barrera, Pilar; Moreda-Piñeiro, Antonio

doi:10.1016/j.aca.2018.02.075

Cited by 33 publications

(23 citation statements)

References 22 publications

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“…The first occurrence of data related to the single-particle characterization and quantification of TiO 2 -Ps-Tot in shellfish was reported in [26,27], although the authors did not reduce the particle acquisition spectrum to the nano-fraction of 100 nm in diameter. Taboada-López et al (2018) processed different shellfish species collected both fresh and frozen at the supermarket, by applying an ultrasound-assisted enzyme digestion and spICP-MS analysis.…”

Section: Discussionmentioning

confidence: 99%

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Chemical Characterization and Quantification of Titanium Dioxide Nanoparticles (TiO2-NPs) in Seafood by Single-Particle ICP-MS: Assessment of Dietary Exposure

Grasso

Ferrante

Zuccarello

et al. 2020

IJERPH

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The significant increase in the production and variety of nanoparticles (NPs) has led to their release into the environment, especially into the marine environment. Titanium dioxide nanoparticles (TiO2-NPs) are used in different industrial sectors, from the food industry to several consumer and household products. Since the aquatic environment is highly sensitive to contamination by TiO2-NPs, this work aimed to give a preliminary assessment of the contamination of packaged seafood, where the food additive TiO2 (E171) is not to be intentionally added. This allowed providing a chemical characterization and quantification of TiO2-NPs in processed canned fish products belonging to different trophic positions of the pelagic compartment and in canned clam. The new emerging technique called single-particle inductively coupled plasma mass spectrometry (spICP-MS) was applied, which allows the determination of nanoparticle number-based concentration, as well as the dissolved titanium. This study highlights how processed food, where the pigment E171 was not intentionally added, contains TiO2 in its nanoparticle form, as well as dissolved titanium. Processed clam represented the seafood with the highest content of TiO2-NPs. In pelagic fish species, we found progressively higher levels and smaller sizes of TiO2-NPs from smaller to larger fish. Our results highlight the importance of planning the characterization and quantification of TiO2-NPs in food both processed and not, as well as where the pigment E171 is intentionally added and not, as it is not the only source of TiO2-NPs. This result represents a solid step toward being able to estimate the real level of dietary exposure to TiO2-NPs for the general population and the related health risks.

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Section: Discussionmentioning

confidence: 99%

“…Since the aquatic environment is highly sensitive to contamination by TiO 2 -NPs [13], this work aimed to give a preliminary assessment of the contamination of packaged food derived from marine environment. According to the literature, very few studies reported the levels of nanoparticles in marine organisms [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization and Quantification of Titanium Dioxide Nanoparticles (TiO2-NPs) in Seafood by Single-Particle ICP-MS: Assessment of Dietary Exposure

Grasso

Ferrante

Zuccarello

et al. 2020

IJERPH

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show abstract

“…Aquatic organisms. The analysis of aquatic organisms has included plankton, 228 crustaceans, 228 molluscs 228,246,[264][265][266] and fishes. 228 In all cases, prior to SP-ICP-MS analysis, nanoparticles were extracted by digestion of the biological matrices.…”

Section: Scenario 33: Analysis Of Biological Samplesmentioning

confidence: 99%

“…228 In all cases, prior to SP-ICP-MS analysis, nanoparticles were extracted by digestion of the biological matrices. Enzymatic digestions included the use of pancreatin/lipase, 246,264,265 whereas alkaline digestions were based on the use of TMAH. 228,266 The most studied elements have been Ti 228,246,265 and Ag, 228,246,264 although nanoparticles containing Cu, 246 Zn 246 or different rare earth elements 266 have been also considered.…”

Section: Scenario 33: Analysis Of Biological Samplesmentioning

confidence: 99%

“…Enzymatic digestions included the use of pancreatin/lipase, 246,264,265 whereas alkaline digestions were based on the use of TMAH. 228,266 The most studied elements have been Ti 228,246,265 and Ag, 228,246,264 although nanoparticles containing Cu, 246 Zn 246 or different rare earth elements 266 have been also considered. In relation to the information reported, all the articles provided quantitative information of particle mass and number concentration, particle size distribution and mean size.…”

Section: Scenario 33: Analysis Of Biological Samplesmentioning

confidence: 99%

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Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review

et al. 2021

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Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats

Toledano‐Serrabona

Camps‐Font

Moraes

et al. 2022

Journal of Periodontology

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Background The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris. Methods Twenty Sprague‐Dawley rats were randomly distributed into three groups: an experimental group with a mandibular bone defect filled with metallic debris obtained by implantoplasty; a positive control group; and a negative control group. Thirty days after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect was removed, together with the lungs, spleen, liver, and brain. Two blood samples were collected: immediately before surgery and before euthanasia. The perilesional tissue was histologically analyzed using hematoxylin‐eosin staining, and Ti, aluminum, and vanadium ion concentrations in blood and organs were measured by TQ‐ICP‐MS. Descriptive and bivariate analyses of the data were performed. Results All rats with implanted metal debris showed metal particles and a bone fracture callus on the osseous defect. The metal particles were surrounded by a foreign body reaction characterized by the presence of histiocytes and multinucleated giant cells (MNGCs). The experimental group had a significant higher concentration of Ti ions in all studied organs except lung tissue (p < 0.05). In addition, there were more V ions in the brain in the experimental group (p = 0.008). Conclusions Although further studies are required to confirm the clinical relevance of these results, Ti metal particles in the jaw might increase the concentration of metal ions in vital organs and induce a foreign body reaction.

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Ultrasound assisted enzymatic hydrolysis for isolating titanium dioxide nanoparticles from bivalve mollusk before sp-ICP-MS

Cited by 33 publications

References 22 publications

Chemical Characterization and Quantification of Titanium Dioxide Nanoparticles (TiO2-NPs) in Seafood by Single-Particle ICP-MS: Assessment of Dietary Exposure

Chemical Characterization and Quantification of Titanium Dioxide Nanoparticles (TiO2-NPs) in Seafood by Single-Particle ICP-MS: Assessment of Dietary Exposure

Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review

Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats

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