Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats

Toledano‐Serrabona, Jorge; Camps‐Font, Octavi; Moraes, Diogo Pompéu de; Corte‐Rodríguez, Mario; Montes-Bayón, Marı́a; Valmaseda‐Castellón, Eduard; Gay‐Escoda, Cosme; Sánchez-Garcés, María Ángeles

doi:10.1002/jper.22-0091

Cited by 13 publications

(8 citation statements)

References 47 publications

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“…Regarding Ti ions and particles, it is known that both can coexist in the peri-implant environment. A recent study showed that metal particles embedded in an experimental rat mandible defect triggered chronic inflammation with a foreign body granulomatous reaction characterized by the presence of histiocytes and MNGCs, i.e, Ti metal particles induced a chronic inflammatory cell infiltrate associated with a foreign body reaction ( 76 ). Interestingly, new evidence suggests a spatiotemporal distribution of macrophages in the FBR, therefore, a microenvironment may exist or be created within and around the biomaterial and that different macrophage phenotypes are associated with these different spaces ( 77 ).…”

Section: Stages Of Osseointegration Failurementioning

confidence: 99%

Osteoimmune regulation underlies oral implant osseointegration and its perturbation

et al. 2023

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In the field of biomaterials, an endosseous implant is now recognized as an osteoimmunomodulatory but not bioinert biomaterial. Scientific advances in bone cell biology and in immunology have revealed a close relationship between the bone and immune systems resulting in a field of science called osteoimmunology. These discoveries have allowed for a novel interpretation of osseointegration as representing an osteoimmune reaction rather than a classic bone healing response, in which the activation state of macrophages ((M1–M2 polarization) appears to play a critical role. Through this viewpoint, the immune system is responsible for isolating the implant biomaterial foreign body by forming bone around the oral implant effectively shielding off the implant from the host bone system, i.e. osseointegration becomes a continuous and dynamic host defense reaction. At the same time, this has led to the proposal of a new model of osseointegration, the foreign body equilibrium (FBE). In addition, as an oral wound, the soft tissues are involved with all their innate immune characteristics. When implant integration is viewed as an osteoimmune reaction, this has implications for how marginal bone is regulated. For example, while bacteria are constitutive components of the soft tissue sulcus, if the inflammatory front and immune reaction is at some distance from the marginal bone, an equilibrium is established. If however, this inflammation approaches the marginal bone, an immune osteoclastic reaction occurs and marginal bone is removed. A number of clinical scenarios can be envisioned whereby the osteoimmune equilibrium is disturbed and marginal bone loss occurs, such as complications of aseptic nature and the synergistic activation of pro-inflammatory pathways (implant/wear debris, DAMPs, and PAMPs). Understanding that an implant is a foreign body and that the host reacts osteoimmunologically to shield off the implant allows for a distinction to be drawn between osteoimmunological conditions and peri-implant bone loss. This review will examine dental implant placement as an osteoimmune reaction and its implications for marginal bone loss.

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Section: Stages Of Osseointegration Failurementioning

confidence: 99%

Osteoimmune regulation underlies oral implant osseointegration and its perturbation

et al. 2023

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“…Moreover, foreign body reaction is a complex process involving the interaction of various immune cells, and not only macrophages. [20] In another rat study, Toledano-Serrabona and colleagues [29] evaluated mandibular bone defects in Sprague-Dawley rats, filled with metallic debris obtained by implantoplasty from Ti-6Al-4V dental implants.…”

Section: In Vitro and Preclinical Studiesmentioning

confidence: 99%

“…In another rat study, Toledano-Serrabona and colleagues [ 29 ] evaluated mandibular bone defects in Sprague-Dawley rats, filled with metallic debris obtained by implantoplasty from Ti-6Al-4V dental implants.…”

Section: Effect Of Titanium Particles and Ions In Inducing Foreign Bo...mentioning

confidence: 99%

The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis

2022

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Titanium (Ti) particles and ions have been investigated in recent years as important factors in the pathogenesis of peri-implantitis. However, their role in the pathogenesis is yet to be fully understood. A review of pertinent literature was performed in various databases to determine the current position of Ti particles and ions role in the pathogenesis of peri-implantitis. There are several <i>in vitro</i>, preclinical and clinical published studies that have addressed the role of Ti particles and ions in the pathogenesis of peri-implantitis. These studies explored the effect of Ti particles and ions in the pathogenesis of peri-implantitis with respect to foreign body reaction, cellular response, epigenetic mechanisms, namely DNA methylation, and the oral microbiome. Studies have shown that the release of Ti particles/ions during implant insertion, early healing stages, late healing stages, and treatments during peri-implantitis might contribute to peri-implantitis through different mechanisms, such as foreign body reaction, cellular response, DNA methylation, and shaping the oral microbiome by increasing dysbiosis. However, further studies are needed to elucidate the complex interactions between all these mechanisms and Ti particles/ions in the pathogenesis and progression of peri-implantitis.

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“…According to many works in the scientific literature, titanium-roughened surfaces enhance osseointegration [2] and are, therefore, available in the majority of marketed implant systems. Nevertheless, some researchers have pointed out the release of titanium ions/particles within adjacent tissues [3] as a result of tribocorrosion [4] or implantoplasty [5] and their possible role in promoting allergies, which may be underestimated due to the detection protocols being optimized for dermatology [6].…”

Section: Introductionmentioning

confidence: 99%

Mechanical and Biological Characterization of PMMA/Al2O3 Composites for Dental Implant Abutments

Roato,

Genova,

Duraccio

et al. 2023

Polymers

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The mechanical and biological behaviors of PMMA/Al2O3 composites incorporating 30 wt.%, 40 wt.%, and 50 wt.% of Al2O3 were thoroughly characterized as regards to their possible application in implant-supported prostheses. The Al2O3 particles accounted for an increase in the flexural modulus of PMMA. The highest value was recorded for the composite containing 40 wt.% Al2O3 (4.50 GPa), which was about 18% higher than that of its unfilled counterpart (3.86 GPa). The Al2O3 particles caused a decrease in the flexural strength of the composites, due to the presence of filler aggregates and voids, though it was still satisfactory for the intended application. The roughness (Ra) and water contact angle had the same trend, ranging from 1.94 µm and 77.2° for unfilled PMMA to 2.45 µm and 105.8° for the composite containing the highest alumina loading, respectively, hence influencing both the protein adsorption and cell adhesion. No cytotoxic effects were found, confirming that all the specimens are biocompatible and capable of sustaining cell growth and proliferation, without remarkable differences at 24 and 48 h. Finally, Al2O3 was able to cause strong cell responses (cell orientation), thus guiding the tissue formation in contact with the composite itself and not enhancing its osteoconductive properties, supporting the PMMA composite’s usage in the envisaged application.

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Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats

Cited by 13 publications

References 47 publications

Osteoimmune regulation underlies oral implant osseointegration and its perturbation

Osteoimmune regulation underlies oral implant osseointegration and its perturbation

The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis

Mechanical and Biological Characterization of PMMA/Al2O3 Composites for Dental Implant Abutments

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