Ultrasound assisted cocrystallization from solution (USSC) containing a non-congruently soluble cocrystal component pair: Caffeine/maleic acid

Aher, Suyog; Dhumal, Ravindra S.; Mahadik, Kakasaheb R.; Paradkar, Anant; York, Peter

doi:10.1016/j.ejps.2010.08.012

Cited by 91 publications

(69 citation statements)

References 28 publications

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“…Aher et al 6 used stoichiometric variation of the co-crystal forming components in menthol in the presence of ultrasound. In this study, a high solubility component was found to be required in high amounts in solution to keep both co-crystal forming components in a saturated state.…”

Section: Introductionmentioning

confidence: 99%

“…The sonochemistry reports available to date on co-crystallization of caffeine -maleic acid have used organic solvents. 6 Here, we have carried out a study to understand the effect of ultrasound on caffeine and maleic acid co-crystallization in water. The aqueous solubility of caffeine is 0.101 mM and maleic acid is 7.431 mM.…”

Section: Introductionmentioning

confidence: 99%

“…Caffeine -dicarboxylic acid is the most studied co-crystal pair showing non-congruency. [3][4][5][6][7][8] Several approaches have been used to overcome the non-congruent solubility of co-crystal components. Friščić et al 4 carried out ultrasound assisted slurry cocrystallization experiments using different organic solvents for caffeine with l-malic acid or l-tartaric acid.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization

Apshingekar

Aher

Kelly

et al. 2017

Journal of Pharmaceutical Sciences

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ABSTRACT:A green approach has been used for co-crystallization of non-congruent co-crystal pair of caffeinemaleic acid using water. Ultrasound is known to affect crystallization hence the effect of high power ultrasound on the ternary phase diagram has been investigated in detail using a slurry co-crystallization approach. A systematic investigation was performed to understand how the accelerated conditions during ultrasound assisted co-crystallization will affect different regions of the ternary phase diagram.Application of ultrasound showed considerable effect on the ternary phase diagram; principally on caffeine/maleic acid 2:1 (disappeared) and 1:1 co-crystal (narrowed) regions. Also, the stability regions for pure caffeine and maleic acid in water were narrowed in the presence of ultrasound, expanding the solution region. The observed effect of ultrasound on the phase diagram was correlated with solubility of caffeine and maleic acid and stability of co-crystal forms in water.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization

Apshingekar

Aher

Kelly

et al. 2017

Journal of Pharmaceutical Sciences

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“…Grinding methods are of two types: neat grinding and solvent drop grinding [85,86] . Some newly emerging methods used for the formation of cocrystals are ultrasound assisted solution method [87,88] , supercritical fluid atomization technique [46,89] , spray drying technique [90,91] , hot melt extrusion technique [92,93] .…”

Section: Differnt Methods Of Cocrystals Formationmentioning

confidence: 99%

“…The solution is kept overnight for drying. Pure cocrystals were obtained by this method and the purity of cocrystals can be assessed by using X-ray diffraction study [88] .…”

Section: Ultrasound Assisted Solution Cocrystallizationmentioning

confidence: 99%