“…Besides being thicker, the organic layers formed in the case of Ag@SU and Ag@CU were more dense and compact, which proved the beneficial role of ultrasound cavitation for the dispersion of EO's molecules [73,74] and resulted in a reduced particle aggregation. In contrast to other studies on the sonochemical synthesis of AgNPs [75,76], the particle size of Ag@SU and Ag@CU was slightly increased, when compared with Ag@EO NPs obtained by conventional reduction. We asserted that this particular situation was due to (i) the reduced intensity of acoustic waves generated by the ultrasonic bath in comparison with those generated by the sonication probe and (ii) the thicker EO layer formed onto the particles, as the HR-TEM evidenced a much smaller inorganic core and a significantly thicker organic layer for Ag@SU and Ag@CU than in the case of conventionally synthesized Ag@EO NPs.…”
The beneficial synergy between antimicrobial silver nanoparticles (AgNPs) and essential oils (EOs), with therapeutic effects that have been acknowledged and explored for a long time, opens the way towards developing new and promising alternatives for anti-infective therapies. With the aim to improve the cytocompatibility and stability of AgNPs and to overcome the volatilization of EOs, AgNPs conjugated with sage (Salvia officinalis) and cinnamon (Cinnamomum aromaticum) EOs were obtained in our study. The synthesis process was realized either by classical or ultrasound-assisted chemical reduction. Compositional and microstructural characterization of the as-obtained Ag@EO NPs was performed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The biodistribution of Ag@EO NPs was evaluated on a mouse animal model.
“…Besides being thicker, the organic layers formed in the case of Ag@SU and Ag@CU were more dense and compact, which proved the beneficial role of ultrasound cavitation for the dispersion of EO's molecules [73,74] and resulted in a reduced particle aggregation. In contrast to other studies on the sonochemical synthesis of AgNPs [75,76], the particle size of Ag@SU and Ag@CU was slightly increased, when compared with Ag@EO NPs obtained by conventional reduction. We asserted that this particular situation was due to (i) the reduced intensity of acoustic waves generated by the ultrasonic bath in comparison with those generated by the sonication probe and (ii) the thicker EO layer formed onto the particles, as the HR-TEM evidenced a much smaller inorganic core and a significantly thicker organic layer for Ag@SU and Ag@CU than in the case of conventionally synthesized Ag@EO NPs.…”
The beneficial synergy between antimicrobial silver nanoparticles (AgNPs) and essential oils (EOs), with therapeutic effects that have been acknowledged and explored for a long time, opens the way towards developing new and promising alternatives for anti-infective therapies. With the aim to improve the cytocompatibility and stability of AgNPs and to overcome the volatilization of EOs, AgNPs conjugated with sage (Salvia officinalis) and cinnamon (Cinnamomum aromaticum) EOs were obtained in our study. The synthesis process was realized either by classical or ultrasound-assisted chemical reduction. Compositional and microstructural characterization of the as-obtained Ag@EO NPs was performed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The biodistribution of Ag@EO NPs was evaluated on a mouse animal model.
“…The FTIR spectra confirm the presence of active biomolecules in the plant extract, which acted as capping and reducing agents, reducing Ag + to Ag 0 . 8,27 X-ray diffraction (XRD) is one of the most extensively used techniques for the characterization of NPs. The X-ray diffraction pattern of 0.01 mol/L AME-AgNPs exhibited four distinct diffraction peaks at 38.24°, 44.13°, 77.55.11° and 84.32° corresponding to the 111, 200, 220 and 311 planes, respectively (Figure 4).…”
Section: Resultsmentioning
confidence: 99%
“…The FTIR spectra confirm the presence of active biomolecules in the plant extract, which acted as capping and reducing agents, reducing Ag + to Ag 0 . 8 , 27 Figure 3 FTIR spectrum recorded for (a) AME-flower powder and (b) AgNPs synthesized using AME flower extract. …”
Background: Abelmoschus esculentus (L.) Moench, an economically important malvaceous vegetable crop popularly known as okra, is used in various culinary preparations and is rich in vitamins, minerals, and nutrients. The biological properties of okra flowers in relation to nanoparticle synthesis have not yet been reported. Materials and Methods: In the current study, silver nanoparticles (AgNPs) were synthesized using extracts of the flowers of A. esculentus. The characteristics of the AgNPs were studied using a UV-vis spectrometer, Fourier transmission infrared spectrophotometer (FTIR), X-ray diffractometer (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM) and energy dispersive X-ray spectrometer (EDX). Antibacterial activity screening was performed using the agar well diffusion method, and cytotoxicity and cell viability studies were conducted using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: The synthesized AgNPs were spherical and ranged in size from 5.52 to 31.96 nm, with an average size of 16.19 nm, as determined by UV-vis spectroscopy, FTIR, XRD, TEM and EDX. A. esculentus flower extract-mediated silver nanoparticles (AME-AgNPs) exhibited excellent activities in vitro studies, particularly in vitro cytotoxic and antiproliferative studies against cancer cell lines, such as the TERT-4 and A-549 cell lines. The antibacterial effects on the Gram-positive pathogens Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes and the Gram-negative pathogens Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella typhimurium and Shigella sonnei were tested. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values varied with the bacterial strain. The IC 50 values of the synthesized NPs for the tested cell lines were close to that of a standard drug.
Conclusion:Compared to other NPs the NPs synthesized in this study were smaller in size and exhibited a higher level of antibacterial activity, cytotoxicity and apoptosis at minimal concentrations, and this is the first study on okra flower-induced anticancer and antimicrobial activities.
“…Indeed, as shown in Figure 2, the type 1 fimbriae which is sensitive to mannose is blocked by fructose and PACs block the others type 1 fimbria mannose-resistant: this reduces the adhesion capacity of the bacteria and enables the bladder to "flush out" the UPs when urine is expelled (Sihra et al, 2018). In addition, randomized controlled trials have shown that cranberry juice can reduce the (Saratale et al, 2019;Sheikh and Ishnava, 2020); CuO (Ramesh et al, 2020) Caesalpinia nuga (L.) (Fatimah et al, 2020); Au (Chan et al, 2020); MgO and ZnO (Priya et al, 2020) Lamiaceae P. vulgaris Ag (Surya et al, 2016; CuO (Dinesh et al, 2020); ZnO (Manokari et al, 2017) (Mousavi et al, 2020); Ag (Feizi et al, 2018;Esfanddarani et al, 2017); CuO (Taran et al, 2017) Meliaceae Azadirachta indica A.…”
Section: Use Of Plants Extract Phytochemicals and Green-synthetized Nanoparticles Against Utis And Upsmentioning
Urinary tract infections (UTIs) are among the most common infections in most countries and they are usually caused by the so-called uropathogenic (UP) microorganisms, including Escherichia coli (80%-90%), Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus mirabilis, and Klebsiella pneumoniae. Over the years, the growth of resistance to antibiotics has complicated the treatment of UTIs and has direct consequences on the cost of treatment, the severity of infections, and the length of hospitalization. Medicinal plants, used for thousands of years to treat various diseases, constitute a serious alternative to antibiotics in the public health issue of antimicrobial resistance. In this review, the in vitro and in vivo use of medicinal plants and their nanoparticles (silver, gold, zinc, copper oxide, magnesium oxide, iron, etc.) in the management of uropathogens and their virulence factors (VFs) as well as in the management of UTIs themselves have been discussed. Given the advantages offered by the biologically active compounds of medicinal plants as well as their green-synthetized nanoparticles whether used as such or in combination with conventional antibiotics, it can be concluded that herbal medicine can significantly help in the management of UTIs.
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