Ultrasound and molecular genetic diagnostic methods for Rh-isoimmunized pregnancy

Abstract

Hemolytic disease of the newborn (HDN) in Russia is diagnosed in approximately 0.6% of them [6]. There are 19 main erythrocyte group systems that combine more than 100 antigens, as well as numerous private and common erythrocyte antigens with other tissues [9]. Typically, the baby's red blood cells have some of the paternal antigens that the mother does not have. At the same time, HDN usually develops due to incompatibility between the fetus and mother for Rh or ABO antigens, rarely for other antigenic systems (due to their lower immunogenicity).