Ultrasound Ablation (HIFU) in the Treatment of Pancreatic Unresectable Tumors

Карпов, О Э; Ветшев, П С; Бруслик, С. В.; Sviridova, T. I.; Левчук, А Л; Sarzhevskiy, V. O.; Sudilovskaya, V. V.

doi:10.16931/1995-5464.2015317-23

Cited by 3 publications

(2 citation statements)

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“…А также стоит отметить, что в процессе проведения радиочастотной аблации происходит выработка белков теплового шока, которые в свою очередь стимулируют противоопухолевый иммунный ответ [11,12,13]. Данная методика является малоинвазивным вмешательством, при котором отмечается низкий риск осложнений, короткий реабилитационный период, и снижение вероятности возникновения ранних рецидивов в сравнении с открытым хирургическим вмешательством [1,2]. Также преимуществом данного метода является его экономическая составляющая, в виду отсутствия интубационного наркоза при проведении данного вмешательства (выполняется под внутривенной седацией) и использования небольшого количества расходных материалов [6,14].…”

Section: Successful Application Of Radiofrequency Ablation For Malign...unclassified

Successful application of radiofrequency ablation for malignant neoplasms of the pancreas

Malikhova,

Bogdanova,

Komarova

et al. 2023

jour

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A distinctive feature of pancreatic cancer is its aggressiveness and rapidity. Neuroendocrine tumors are distinguished among neoplasms of the pancreas. Pancreatic neuroendocrine tumors are diagnosed on the basis of anamnesis, laboratory tests and the results of instrumental studies. However, the non-specific character of symptoms does not allow early detection of the disease. In a large proportion of patients, pancreatic neoplasms are diagnosed at stages III-IV. Radiofrequency ablation is an invasive intervention with the high temperature local effect on the tumor, resulting in the death of neoplastic cells. The method is based on the effect of high-frequency radio waves on pathological tissues. 6 radiofrequency ablations of neuroendocrine tumors of the pancreas under the control of endoscopic ultrasonography were performed at the N. N. Blokhin Oncology Research Center. There were no complications in the postoperative period. All patients were discharged with recommendations for supervision of an oncologist at their place of residence. It is also noted that such a method of treatment improves the further course of the disease and the life quality in patients.

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Section: Successful Application Of Radiofrequency Ablation For Malign...unclassified

Successful application of radiofrequency ablation for malignant neoplasms of the pancreas

Malikhova,

Bogdanova,

Komarova

et al. 2023

jour

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“…The largest Russian HIFU experience for pancreatic carcinoma was presented by P. Vetshev [35]. Eighteen HIFU were carried out between 2009 and 2014 upon 16 patients.…”

Section: Radiofrequency Ablationmentioning

confidence: 99%

Treatment of Insulinomas with Minimally Invasive Physical Procedure. Literature Review

Берелавичус

Кригер

Dugarova

et al. 2018

SN Compr. Clin. Med.

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Insulinoma is the most common functioning pancreatic neuroendocrine tumor with the development of the organic hyperinsulinism and the severe hypoglycemia. Insulinoma can be treated radically only by surgical removal. In cases when the surgery may cause severe complications with the high risk of mortality, the physical non-surgical methods can be used. The world literature review using PubMed, MedScape, and Cochrane databases was performed. Keywords Binsulinoma^+ Bphysical methods^were used including every type of the method. One hundred fifty-two articles in English devoted to different physical methods of treatment of neuroendocrine tumors were found. Twenty-seven papers with the description of the minimally invasive treatment of insulinomas were found among them. There were data about the different methods revealed such as radiofrequency ablation, microwave ablation, cryodestruction, laser ablation, irreversible electroporation, photodynamic therapy, high-intensity focused ultrasound, Cyberknife, and tumor alcoholization. Literature search showed that there are a few papers about the description of the self-experience of each method, but there are no papers with the full compartment of advantages and disadvantages of each method of treatment. Each method was used because of its availability in the hospital or department. Contemporary statement of the physical mini-invasive method of insulinomas treatment requires investigations with the full randomized trials. These researches can identify the points to use one or another physical method and to choose the most right way to treat patients with hormonal-producing pancreatic neuroendocrine tumors.

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Ultrasound ablation for metastatic liver cancer and unresectable pancreatic tumors

Карпов¹,

Ветшев²,

Бруслик³

et al. 2018

Ann. hir. gepatol.

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Material and methods. Ultrasound ablation has been performed in 165 patients with metastatic liver cancer (metastases of colorectal cancer as a rule) and in 17 patients with unresectable pancreatic neoplasms for the period from April 2009 to December 2017. All patients with metastatic liver cancer underwent previous surgery for primary tumor. In 53% of cases unresectable pancreatic tumor was complicated by mechanical jaundice that required biliary drainage and stenting before ablation. Ultrasound and contrast-enhanced CT were applied to assess changes of tumor dimensions, its structure compared with initial data, vascularization grade, continued growth or de novo metastases with positive changes within destruction area. Percutaneous biopsy of liver and pancreatic tumors was carried out in 136 patients (75%) to assess morphological changes of tumor in pre- and postoperative period. Results. There were no intra – and postoperative complications. Three types of changes occurring within destruction area were revealed. Positive changes including changes of tumor structure, reduced dimensions and volume were observed in 76 (46%) patients. 38 (23%) patients had either augmentation of dimensions and volume of destruction area or appearance of additional tumor tissue on the periphery of metastasis. De novo liver metastases or other distant ones occurred in 51 (31%) patients with positive changes in destruction area. Oncologists of our center evaluated immediate and long-term outcomes of combined treatment. Reduced tumor dimension on the background of mild or absent pain syndrome were confirmed in 12 (72%) patients after ablation of pancreatic tumor. In 8 out of 12 patients weight gain and absent pain syndrome were observed within 48 months. Conclusion. Ultrasound ablation is effective and safe for local destruction of secondary liver tumors and unresectable pancreatic tumors. This approach is indicated for inoperable cases and as a stage of combined treatment.

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Ultrasound Ablation (HIFU) in the Treatment of Pancreatic Unresectable Tumors

Cited by 3 publications

References 0 publications

Successful application of radiofrequency ablation for malignant neoplasms of the pancreas

Successful application of radiofrequency ablation for malignant neoplasms of the pancreas

Treatment of Insulinomas with Minimally Invasive Physical Procedure. Literature Review

Ultrasound ablation for metastatic liver cancer and unresectable pancreatic tumors

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