Ultrasonication for production of nanoliposomes with encapsulated soy protein concentrate hydrolysate: Process optimization, vesicle characteristics and in vitro digestion

Pavlović, Neda; Mijalković, Jelena; Đorđević, Verica; Pecarski, Danijela; Bugarski, Branko; Knežević‐Jugović, Zorica

doi:10.1016/j.fochx.2022.100370

Cited by 12 publications

(2 citation statements)

References 37 publications

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“…It had also been shown that the greater stability of liposomes depends on the storage conditions, namely the storage temperature [ 42 ]. As in the present study, 4 °C is the most preferred temperature as it eliminates thermal effects on the vesicles and the lipid bilayer remains more rigid [ 43 , 44 ]. The strongest increase in size and PdI was observed for the PC/Tw20 system.…”

Section: Discussionmentioning

confidence: 99%

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Васильева

Gaynanova

Zueva

et al. 2022

IJMS

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For the first time, the efficacy of post-exposure treatment of organophosphate (OP) poisoning was increased by transdermal delivery of acetylcholinesterase (AChE) reactivator pyridine-2-aldoxime methochloride (2-PAM) as a preventive countermeasure. By selecting the optimal ratio of components, classical transfersomes (based on soybean phosphatidylcholine and Tween 20) and modified transfersomes (based on soybean phosphatidylcholine, Tween 20 and pyrrolidinium cationic surfactants with different hydrocarbon tail lengths) were obtained for 2-PAM encapsulation. Transfersomes modified with tetradecylpyrrolidinium bromide showed the best results in encapsulation efficiency and sustained release of 2-PAM from vesicles. Using Franz cells, it was found that the incorporation of surfactants into PC liposomes results in a more prolonged release of 2-PAM through the rat skin. Transfersomes containing 2-PAM, after exhaustive physical and chemical characterization, were embedded in a gel based on Carbopol® 940. A significantly high degree of erythrocyte AChE reactivation (23 ± 7%) was shown for 2-PAM in unmodified transfersomes in vivo. Preliminary transdermal administration of 2-PAM 24 h before emergency post-exposure treatment of OP poisoning leads to an increase in the survival rate of rats from 55% to 90%.

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Section: Discussionmentioning

confidence: 99%

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Васильева

Gaynanova

Zueva

et al. 2022

IJMS

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show abstract

“…It has been observed that with ultrasonication treatment time, an increase in peptide concentration is accompanied by an enhancement in antioxidant activity [72] . Selenium-containing peptide TSeMMM is an immunomodulatory functioning peptide mainly extracted from selenium-enriched rice protein [73] . However, its biological activity is hampered during gastrointestinal digestion.…”

Section: Role In Bioactivitymentioning

confidence: 99%

Sustainable emerging high-intensity sonication processing to enhance the protein bioactivity and bioavailability: An updated review

Hussain

Gantumur

Manzoor

et al. 2023

Ultrasonics Sonochemistry

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Review of fish protein hydrolysates: production methods, antioxidant and antimicrobial activity and nanoencapsulation

Nemati,

Shahosseini,

Ariaii

2024

Food Sci Biotechnol

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Ultrasonication for production of nanoliposomes with encapsulated soy protein concentrate hydrolysate: Process optimization, vesicle characteristics and in vitro digestion

Cited by 12 publications

References 37 publications

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Sustainable emerging high-intensity sonication processing to enhance the protein bioactivity and bioavailability: An updated review

Review of fish protein hydrolysates: production methods, antioxidant and antimicrobial activity and nanoencapsulation

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