Ultrasonically assisted fabrication of vaterite submicron-sized carriers

Svenskaya, Yulia I.; Fattah, HA; Am, Zakharevich; Gorin, Dmitry A.; Sukhorukov, Gleb B.; Parakhonskiy, Bogdan

doi:10.1016/j.apt.2016.02.014

Cited by 41 publications

(44 citation statements)

References 50 publications

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“…In the study of L. Dupont et al, it was shown that vigorous agitation of working solution during CaCO 3 particle formation, which aids rapid homogenous distribution of reagents in the volume, leads to the occurrence of a larger number of growth centers. The cavitation effects in solution, occurring from ultrasonic impact, sustain the intensive stirring of the solution and have the same influence . The ultrasound prevents formation of big particles and their aggregates in the bulk solution and stimulates their dissolution, and at the same time sustains a free circulation of Ca 2+ and

{CO}_{3}^{2 -}

ions in the system.…”

Section: Discussionmentioning

confidence: 99%

“…The cavitation effects in solution, occurring from ultrasonic impact, sustain the intensive stirring of the solution and have the same influence. 54 The ultrasound prevents formation of big particles and their aggregates in the bulk solution and stimulates their dissolution, and at the same time sustains a free circulation of Ca 21 and CO 22 3 ions in the system. In addition, the ultrasonic treatment provides the penetration of solutions into pores and interior of the fibrous material, which facilitates the homogenous mineralization of the scaffold.…”

Section: Original Articlementioning

confidence: 99%

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Vaterite coatings on electrospun polymeric fibers for biomedical applications

Savelyeva

Abalymov

Lyubun

et al. 2016

J Biomedical Materials Res

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The process of porous calcium carbonate (CaCO ) covering on electrospun poly(ε-caprolactone) (PCL) fibers is described in this study. Uniform CaCO coatings, composed of vaterite microparticles and its aggregates, were formed on PCL fibers by mineral precipitation from solution under ultrasonic treatment. The porous structure of CaCO in vaterite polymorphic form is useful for loading of various substances (drugs and nanoparticles), and this property makes vaterite an appropriate material for design of drug delivery systems. Such mineralization was implemented to attain therapeutic and/or biological activity of tissue engineering scaffolds based on electrospun PCL, by means of CaCO coatings. Various structures and polymorphs of CaCO coatings were obtained by variation of growth conditions (time of fiber incubation in work solution, ultrasonic treatment of this system). Coating homogeneity, CaCO polymorphic form, morphology, and CaCO mass can be controlled by number of successive stages of fibrous material treatment. Cytotoxicity tests showed that PCL fibers mineralized with CaCO did not release substances toxic for cells. SEM images of PCL/CaCO scaffolds cultured with cells demonstrate that scaffolds supported cell adhesion and spreading. The presented results show the new technique of controlled PCL scaffold mineralization with vaterite, and an opportunity of using PCL/CaCO as scaffolds for tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 94-103, 2017.

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{CO}_{3}^{2 -}

ions in the system.…”

Section: Discussionmentioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

Vaterite coatings on electrospun polymeric fibers for biomedical applications

Savelyeva

Abalymov

Lyubun

et al. 2016

J Biomedical Materials Res

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“…Synthetic vaterite particles have been used as a carrier of active compounds for medical treatments [10][11][12][13][14]. They have been tested as a template for biodegradable polymer capsules, which can be used for applications in nanomedicine [10,11,15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis Methods and Favorable Conditions for Spherical Vaterite Precipitation: A Review

Konopacka-Łyskawa

2019

Crystals

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Vaterite is the least thermodynamically stable anhydrous calcium carbonate polymorph. Its existence is very rare in nature, e.g., in some rock formations or as a component of biominerals produced by some fishes, crustaceans, or birds. Synthetic vaterite particles are proposed as carriers of active substances in medicines, additives in cosmetic preparations as well as adsorbents. Also, their utilization as a pump for microfluidic flow is also tested. In particular, vaterite particles produced as polycrystalline spheres have large potential for application. Various methods are proposed to precipitate vaterite particles, including the conventional solution-solution synthesis, gas-liquid method as well as special routes. Precipitation conditions should be carefully selected to obtain a high concentration of vaterite in all these methods. In this review, classical and new methods used for vaterite precipitation are presented. Furthermore, the key parameters affecting the formation of spherical vaterite are discussed.

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“… CaCO 3 carriers allow for effective drug encapsulation by the virtue of porous structure and possess such advantages as biocompatibility, ease of preparation and low cost. Recently, optical monitoring of the carrier degradation into the hair follicles and the dermis has revealed the total resorption of such carriers in vivo . Furthermore, they have been successfully applied for transdermal delivery of the antifungal drug through hair follicles.…”

Section: Introductionmentioning

confidence: 99%

Optimized skin optical clearing for optical coherence tomography monitoring of encapsulated drug delivery through the hair follicles

Svenskaya

Lengert

Terentyuk

et al. 2020

Journal of Biophotonics

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Hair follicles (HF) represent a drug delivery reservoir for improved treatment of skin disorders. Although various particulate systems play an important role in HF‐targeting, their optical monitoring in skin is challenging due to strong light scattering. Optical clearing is an effective approach allowing the increasing of particle detection depth in skin. The enhancement of optical probing depth (OPD) and optical detection depth (ODD) of particle localization using optical coherence tomography (OCT) was evaluated under application of various optical clearing agents (OCAs) together with skin permeability enhancers ex vivo in rats. Efficient OPD increasing was demonstrated for all investigated OCAs. However, skin dehydration under action of hyperosmotic agents led to the worsening of OCT‐contrast in dermis decreasing the ODD. Lipophilic agents provided optical clearing of epidermis without its dehydration. The highest ODD was obtained at application of a PEG‐400/oleic acid mixture. This OCA was tested in vivo showing beneficial ODD and OPD enhancement.

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Ultrasonically assisted fabrication of vaterite submicron-sized carriers

Cited by 41 publications

References 50 publications

Vaterite coatings on electrospun polymeric fibers for biomedical applications

Vaterite coatings on electrospun polymeric fibers for biomedical applications

Synthesis Methods and Favorable Conditions for Spherical Vaterite Precipitation: A Review

Optimized skin optical clearing for optical coherence tomography monitoring of encapsulated drug delivery through the hair follicles

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