Ultrasonic vocalizations in rats anticipating circadian feeding schedules

Opiol, Hanna; Pavlovski, Ilya; Michalik, Mateusz; Mistlberger, Ralph E.

doi:10.1016/j.bbr.2015.02.003

Cited by 17 publications

(17 citation statements)

References 41 publications

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“…The low number of spontaneous USVs found in the current study is consistent with the findings of Opiol et al, who also found a low number of USVs during 24‐hour isolation periods in rats that did not interact with research staff. Both in their study and in the current study, short, flat USVs were the primary type of spontaneous vocalizations observed . The TA muscle contracts with a lower intensity in these short USVs compared with the frequency‐modulated USVs .…”

Section: Discussionsupporting

confidence: 93%

“…In contrast, in elicitation paradigms such as amphetamine administration, hundreds of USVs can be produced per hour in response to high stimulation, although very few USVs are produced during control conditions. 24 The low number of spontaneous USVs found in the current study is consistent with the findings of Opiol et al, 25 who also found a low number of USVs during 24-hour isolation periods in rats that did not interact with research staff. Both in their study and in the current study, short, flat USVs were the primary type of spontaneous vocalizations observed.…”

Section: Discussionsupporting

confidence: 92%

“…Both in their study and in the current study, short, flat USVs were the primary type of spontaneous vocalizations observed. 25 The TA muscle contracts with a lower intensity in these short USVs compared with the frequency-modulated USVs. 15,26 Therefore, these short, unmodulated, infrequent spontaneous vocalizations may not play a large role in the maintenance of the TA.…”

Section: Discussionmentioning

confidence: 88%

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Social isolation alters ultrasonic vocalizations but not thyroarytenoid neuromuscular junctions in old rats

Johnson

2018

The Laryngoscope

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 88%

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Social isolation alters ultrasonic vocalizations but not thyroarytenoid neuromuscular junctions in old rats

Johnson

2018

The Laryngoscope

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“…Given that DA is involved in food entrainment [6, 12, 48, 49], a second reason why FAA may not have increased in rats repeatedly exposed to AMPH is that the neuroplasticity of DA through which AMPH achieves behavioral sensitization is different from the changes in DA that occur with RF. For example, AMPH sensitization relates more to dopaminergic changes involving the D1 receptor, rather than D2 [41, 50, 51].…”

Section: Discussionmentioning

confidence: 99%

Exploring the role of locomotor sensitization in the circadian food entrainment pathway

et al. 2017

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Food entrainment is the internal mechanism whereby the phase and period of circadian clock genes comes under the control of daily scheduled food availability. Food entrainment allows the body to efficiently realign the internal timing of behavioral and physiological functions such that they anticipate food intake. Food entrainment can occur with or without caloric restriction, as seen with daily schedules of restricted feeding (RF) or restricted treat (RT) that restrict food or treat intake to a single feeding time. However, the extent of clock gene control is more pronounced with caloric restriction, highlighting the role of energy balance in regulating clock genes. Recent studies have implicated dopamine (DA) to be involved in food entrainment and caloric restriction is known to affect dopaminergic pathways to enhance locomotor activity. Since food entrainment results in the development of a distinct behavioral component, called food anticipatory activity (FAA), we examined the role of locomotor sensitization (LS) in food entrainment by 1) observing whether amphetamine (AMPH) sensitization results in enhanced locomotor output of FAA and 2) measuring LS of circadian and non-circadian feeding paradigms to an acute injection of AMPH (AMPH cross-sensitization). Unexpectedly, AMPH sensitization did not show enhancement of FAA. On the contrary, LS did develop with sufficient exposure to RF. LS was present after 2 weeks of RF, but not after 1, 3 or 7 days into RF. When food was returned and rats regain their original body weight at 10–15 days post-RF, LS remained present. LS did not develop to RT, nor to feedings of a non-circadian schedule, e.g. variable restricted feeding (VRF) or variable RT (VRT). Further, when RF was timed to the dark period, LS was observed only when tested at night; RF timed to the light period resulted in LS that was present during day and night. Taken together our results show that LS develops with food entrainment to RF, an effect that is dependent on the chronicity and circadian phase of RF but independent of body weight. Given that LS involves reorganization of DA-regulated motor circuitry, our work provides indirect support for the role of DA in the food entrainment pathway of RF. The findings also suggest differences in neuronal pathways involved in LS from AMPH sensitization and LS from RF.

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“…Indeed, increased anticipatory motor behavior was positively correlated with frequency of high ultrasonic vocalizations (Brenes and Schwarting, 2015). High ultrasonic vocalizations were emitted in anticipation of several rewarding stimuli, including food (Buck et al , 2014b; Opiol et al , 2015), a cocaine or ethanol reward (Buck et al , 2014a; Ma et al , 2010), and being reunited with a cage mate after a period of social isolation (Willey and Spear, 2012). As with anticipatory activity, blocking dopamine neurotransmission attenuated high ultrasonic vocalizations in response to food (Buck et al , 2014b).…”

Section: Translational Assessments Of Reward and Motivationmentioning

confidence: 99%

Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders

Der-Avakian

Barnes

Markou

et al. 2015

Translational Neuropsychopharmacology

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Deficits in reward and motivation are common symptoms characterizing several psychiatric and neurological disorders. Such deficits may include anhedonia, defined as loss of pleasure, as well as impairments in anticipatory pleasure, reward valuation, motivation/effort, and reward learning. This chapter describes recent advances in the development of behavioral tasks used to assess different aspects of reward processing in both humans and non-human animals. While earlier tasks were generally developed independently with limited cross-species correspondence, a newer generation of translational tasks has emerged that are theoretically and procedurally analogous across species and allow parallel testing, data analyses, and interpretation between human and rodent behaviors. Such enhanced conformity between cross-species tasks will facilitate investigation of the neurobiological mechanisms underlying discrete reward and motivated behaviors and is expected to improve our understanding and treatment of neuropsychiatric disorders characterized by reward and motivation deficits.

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Ultrasonic vocalizations in rats anticipating circadian feeding schedules

Cited by 17 publications

References 41 publications

Social isolation alters ultrasonic vocalizations but not thyroarytenoid neuromuscular junctions in old rats

Social isolation alters ultrasonic vocalizations but not thyroarytenoid neuromuscular junctions in old rats

Exploring the role of locomotor sensitization in the circadian food entrainment pathway

Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders

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