Ultrasonic studies on paracetamol in aqueous solutions of sodium salicylate and nicotinamide

Singh, Sulochana; Talukdar, Malabika; Dash, Upendra Nath

doi:10.1016/j.molliq.2017.11.099

Cited by 25 publications

(4 citation statements)

References 26 publications

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“…The sound velocity (U) have been determined from the wavelength (λ) and frequency (f) by using the relation (2.9), (2.9) The values of , the adiabatic isentropic compressibility hasbeen calculated from the sound velocity and density data by using the relation, (2.10) Where U = sound velocity and d= density of the solution. For solutions of different concentrations the values of were fitted to an equation of the form [15] (2.11) Where A, B and C = empirical constants.…”

Section: Sound Velocity Calculationmentioning

confidence: 99%

“…The Walden Product, the product of molar conductivity at infinite dilution, and viscosity, provides an evaluation of the water-structuring activity of the solute [23]. 15 3.77 1.86 31.1 308. 15 6.90 1.66 27.4 313.…”

Section: Conductancementioning

confidence: 99%

“…15 6.90 1.66 27.4 313. 15 10. A scrutiny of Tables 3 shows that the value is found to be negative and hence, suggests the process is spontaneous.…”

Section: Conductancementioning

confidence: 99%

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An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

2020

Biointerface Res Appl Chem

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Medication disposal today is an alarming issue and gaining much more awareness from the consumers as well as healthcare professionals. Various molecular interactions surviving in aqueous drug systems may be considered responsible for these health hazards. This paper reports an experimental study of the various physico-chemical properties of poorly water soluble drug, ibuprofen in aqueous system. Conductance of ibuprofen been measured in aqueous medium at different concentrations and temperatures (from 298.15 K to 313.15 K), and the sound velocity and surface tension study are done only at 298.15 K. The experimental data have been analyzed to interpret different derived parameters as well some thermo-acoustical parameters. The surface tensionvalues have also been determined by means of Stalagmometer and the obtained values are compared with the values computed from sound velocity and density values. Insights obtained from the present study about different molecular interactions of ibuprofen can assist public health and waste management authorities to improve pharmaceutical resource handling and management in rural and urban areas. Determination of solubility.As IBP is very less soluble in water, for its solubility measurement an excess quantity of IBP in 100 mL of conductivity water was taken and heated for 30 minutes maintained at 50°C.

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Section: Sound Velocity Calculationmentioning

confidence: 99%

Section: Conductancementioning

confidence: 99%

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An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

2020

Biointerface Res Appl Chem

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“…The therapeutic dose of paracetamol does not cause any negative side effects for human health; however, overdose consumption causes damages to the liver and kidneys . The drug is partially soluble in http://cold%20water, more soluble in hot water and alcohols . Ibuprofen known as 2‐(4‐isobutylphenyl) propionic acid is a ubiquitous nonsteroidal anti‐inflammatory drug with analgesic and anti‐inflammatory properties .…”

Section: Introductionmentioning

confidence: 99%

A rapid and sensitive reversed phase‐HPLC method for simultaneous determination of ibuprofen and paracetamol in drug samples and their behaviors in simulated gastric conditions

Borahan

Unutkan

Şahin

et al. 2018

J of Separation Science

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Paracetamol is a widely used drug for fever and pain relief. Ibuprofen is a common nonsteroidal anti‐inflammatory drug. In this study, a sensitive and accurate reversed phase high performance liquid chromatography method was developed for the simultaneous determination of ibuprofen and paracetamol. The chromatographic separation was achieved on a Phenomenex C18 (250 mm, 4.6 mm, 5 μm) column. Fifty milli molar phosphate buffer (pH 7.5) and methanol were used as mobile phase in a gradient elution mode. The retention times of paracetamol and ibuprofen were 5.7 and 10.4 min, respectively. The linearity of the developed method was established in the range of 0.25 – 250 mg/L with a correlation coefficient of 0.9998 for both analytes. The limit of detection/quantification values were found to be 0.06/0.19 and 0.08/0.26 mg/L for ibuprofen and paracetamol, respectively. The method was successfully applied in drug samples in the form of tablets and suspensions. The calculated concentrations matched with the claimed values on their prospectuses. The drug samples were studied under simulated gastric conditions to determine the behaviors of the analytes in the human body. The obtained results showed no change in the retention time of the analyte peak shapes throughout the 210 minutes.

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Ultrasonic and Conductometric Studies on l-Aspartic Acid and l-Glutamic Acid in Aqueous Solutions of Sodium Acetate

Dhal,

Singh,

Talukdar

2023

J Solution Chem

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Ultrasonic studies on paracetamol in aqueous solutions of sodium salicylate and nicotinamide

Cited by 25 publications

References 26 publications

An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

A rapid and sensitive reversed phase‐HPLC method for simultaneous determination of ibuprofen and paracetamol in drug samples and their behaviors in simulated gastric conditions

Ultrasonic and Conductometric Studies on l-Aspartic Acid and l-Glutamic Acid in Aqueous Solutions of Sodium Acetate

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