Ultrasonic degradation for molecular weight reduction of pharmaceutical cellulose ethers

Goodwin, Daniel; Picout, David R.; Ross‐Murphy, Simon B.; Holland, Simon J.; Martini, Luigi G.; Lawrence, M. Jayne

doi:10.1016/j.carbpol.2010.08.068

Cited by 34 publications

(37 citation statements)

References 42 publications

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“…In particular, these random processes lead to unwanted mono-and oligomers and to modifications of the chemical microstructure of the side groups [25]. On the contrary, only ultrasonic degradation represents a suitable and established method for producing homologous series of lower molecular weights, according to many authors [25][26][27][28]. Moreover, these authors affirm that no side chain reaction takes place and that the structural and chemical structure of the polymer is maintained during the degradation process.…”

Section: Introductionmentioning

confidence: 84%

“…Thanks to the calibration curve, it is possible to determine the quantitative molecular weight reduction. According to the literature, the shape of these degradation profiles should be an exponential decrease, until reaching a limiting molecular weight (M lim ) [26,28]. Degradation profiles of HPG samples (Fig.…”

Section: Characterization Of the Molecular Weight Reductionmentioning

confidence: 99%

“…Ultrasonic treatment can take a long time and any bits of titanium could be shed by the probe [28]. Thus prior to SEC analysis, the degraded polymer samples were first centrifuged …”

Section: Size-exclusion Chromatographymentioning

confidence: 99%

“…Indeed, a very controlled molecular weight is required in these kinds of industries. Considering that most of the articles on ultrasonic degradation of polysaccharides are performed on pharmaceutical [28] and food [24] grade or laboratory samples [26], low polydispersity index are given in the literature. I p of each sample considered in this study according to the degradation time are given in Fig.…”

Section: Characterization Of the Molecular Weight Reductionmentioning

confidence: 99%

“…Moreover, the efficiency of ultrasonic degradation on these molecules has been already established in the literature [25,26,28,29]. On the other hand, hydropropylguar were tested.…”

Section: Introductionmentioning

confidence: 99%

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Use of ultrasonic degradation to study the molecular weight influence of polymeric admixtures for mortars

Poinot

Benyahia

Govin

et al. 2013

Construction and Building Materials

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The aim of this paper is to provide a methodology to study the influence of the molecular weight of polysaccharidic admixtures on mortar properties. A wide range of admixtures with different molecular weight and constant structure was prepared. This has been made possible by the use of ultrasonic treatment, a simple, effective, and without additive method. It appears that cellulose and guar gum derivatives, used as water retention agents, exhibit a significant molecular weight reduction according to the ultrasonic treatment duration. The water retention capacity of the mortars mixed with ultrasonically degraded admixture solutions increases with molecular weight for a same admixture. However, comparing water retention values obtained with similar molecular weight of a same family shows that effectiveness of polysaccharides as water retention agent is not linearly linked to their molecular weight.

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Section: Introductionmentioning

confidence: 84%

Section: Characterization Of the Molecular Weight Reductionmentioning

confidence: 99%

“…Ultrasonic treatment can take a long time and any bits of titanium could be shed by the probe [28]. Thus prior to SEC analysis, the degraded polymer samples were first centrifuged …”

Section: Size-exclusion Chromatographymentioning

confidence: 99%

Section: Characterization Of the Molecular Weight Reductionmentioning

confidence: 99%

“…Moreover, the efficiency of ultrasonic degradation on these molecules has been already established in the literature [25,26,28,29]. On the other hand, hydropropylguar were tested.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Use of ultrasonic degradation to study the molecular weight influence of polymeric admixtures for mortars

Poinot

Benyahia

Govin

et al. 2013

Construction and Building Materials

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Current application of controlled degradation processes in polymer modification and functionalization

Gumel

Annuar

Heidelberg

2013

J of Applied Polymer Sci

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Ecological concerns over the accumulation of polymeric waste material and the demand for functionalized polymers in specialty applications have promoted extensive research on different controlled degradation processes and their use. The production of functionalized or modified polymers by conventional synthetic routes is expensive and time consuming. However, advances in degradation technology have become an enabling factor in the production of modified polymers and their functionalization. Mild irradiation, ozonization, and enzymatic routes are among the processes that have been explored for polymer modification. Biopolymers, such as chitosan, hyaluronic acids, and polyhydroxyalkanoates, are known to be suitable for a diverse number of applications, ranging from biomedical to organic-electronics. At the same time, their high molecular weight, crystallinity, and shelf degradability limit their utility. Controlled degradation processes can be used to prepare these types of polymers with reasonably low molecular weights and to generate radical species that help to stabilize these polymers or to initiate further beneficial reactions. In this article, we review the application of controlled degradation processes for polymer modification and functionalization.

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Effect of ultrasonic irradiation on low-density polyethylene molecular structure

et al. 2019

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Ultrasonic degradation for molecular weight reduction of pharmaceutical cellulose ethers

Cited by 34 publications

References 42 publications

Use of ultrasonic degradation to study the molecular weight influence of polymeric admixtures for mortars

Use of ultrasonic degradation to study the molecular weight influence of polymeric admixtures for mortars

Current application of controlled degradation processes in polymer modification and functionalization

Effect of ultrasonic irradiation on low-density polyethylene molecular structure

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