Ultrasonic-bath-assisted preparation of mononuclear copper(I) thiosemicarbazone complex particles: Crystal structure, characterization and antimicrobial activity

Abstract

Particles of the copper(I) thiosemicarbazone complex [Cu(Brcatsc)(PPh3)2Cl]$CH3CN (1), Brcatsc ¼ 2-bromo-3-phenylpropenalthiosemicarbazone, were synthesized by an ultrasonic-bath-assisted method and characterized by elemental analyses, NMR ( 1 H, 13 C, and 31 P) and FT-IR spectroscopies, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The thermal stability of 1 was studied by thermal gravimetry analysis and its structure was determined by single crystal X-ray diffraction. The compound 1 is a mononuclear complex with the copper(I) ion coordinated in a distorted tetrahedral geometry by one S atom of Brcatsc, two P atoms of two PPh 3 , and one Cl atom. The complex involves the Brcatsc thiosemicarbazone ligand in an S monodentate bonding mode. The antibacterial activity of the ligand and its copper(I) complex was studied against two gram-positive (Staphylococcus aureus and Enterococcus faecalis) and two gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria.

Synthesis, spectroscopic, electrochemical characterization, density functional theory (DFT), time dependent density functional theory (TD‐DFT), and antibacterial studies of some Co(II), Ni(II), and Cu(II) chelates of (E)‐4‐(1,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)‐1‐(3‐hydroxynaphthalen‐2‐yl)methylene) thiosemicarbazide Schiff base ligand

“…Dimethyl sulfoxide (DMSO) was used as a solvent and the mean inhibition zone was measured and compared with the standard antibiotic, enrofloxacin (5 mg/ml). The images of the zone of inhibition were shown in Diagram 1 and the results are presented in Table 9, taking into consideration the stability of the compounds over a range of pH (5)(6)(7)(8)(9)(10)(11) to fit their usefulness in antibacterial studies.…”

“…[4,6] The biological activities of metal chelates vary from those of either metal ions or ligands and its increased (decreased) as described for many transition metal chelates. [7][8][9] In continuation of our ongoing interest in the synthesis of new thiosemicarbazone chelates, [10,11] we report here the synthesis, structural characterization, and antibacterial studies of new Co(II), Ni(II), and Cu(II) chelates of (E)-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-(3-hydroxynaphthalen-2-yl)methylene) thiosemicarbazide Schiff base ligand (Scheme 1).…”

Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

“…The biological importance of these Schiff's base chelates of thiosemicabazides involved the researchers greater than before to develop fresh ligands as antibacterial [16], antimicrobial [17][18][19], antifungal [20,21], antiparasitic [22], antitumor [23], anticancer [24][25][26], antioxidant [27,28], anti-inflammatory [29], anti-HIV [30], antiproliferative [31], antileishmanial activities [32] and antiviral [33]. Tetradentate thiosemicabazone with strong DNA-binding ability was isolated after the condensation of pyruvaldehyde with 4-(aryl)-thiosemicarbazones [34].…”

Antibacterial Activity of Copper Nanoparticles-Chitosan Composite against <i>Vibrio parahaemolyticus</i>

“…In addition, copper is cheaper than other noble metals such as silver and gold. Therefore, studies on the usage of copper nanoparticles against human pathogenic bacteria have been largely conducted (Ramyadevi et al, 2012;Cao Singh et al, 2016;Khalaji et al, 2017) . However, studies investigating antibacterial activity of copper nanoparticles against shrimp pathogenic bacteria especially V. parahaemolyticus are very limited.…”