Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

Jain, Pallavi; Kumar, Dinesh; Chandra, Sulekh

doi:10.14233/ajchem.2019.21475

Cited by 12 publications

(3 citation statements)

References 83 publications

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“…[2] Thiosemicarbazones (NH 2 À NHÀ CSNH 2 ) are the chelating ligands that coordinate with transition metal ions to form complexes and have drawn a lot of attention owing to diverse pharmacological and physiological features. [3] These thiosemicarbazone are usually synthesized via condensation of thiosemicarbazide and carbonyl (aldehyde/ketone) compounds. [4] As thione-thiol tautomers, thiosemicarbazides can coordinate with metal ions neutrally or anionically, depending on whether a proton is lost from thiol-sulfur (SH) or thio-amide nitrogen (NH).…”

Section: Introductionmentioning

confidence: 99%

“…As a result, a number of such novel compounds are reported into this field each year [2] . Thiosemicarbazones (NH 2 −NH−CSNH 2 ) are the chelating ligands that coordinate with transition metal ions to form complexes and have drawn a lot of attention owing to diverse pharmacological and physiological features [3] . These thiosemicarbazone are usually synthesized via condensation of thiosemicarbazide and carbonyl (aldehyde/ketone) compounds [4] .…”

Section: Introductionmentioning

confidence: 99%

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In Vitro, In Silico, ADME and Theoretical Analysis of Mn(II) and Co(II) Complexes Derived from Methyl‐(Z)‐N′‐Carbamothioylcarbamohydrazonate Schiff Base Ligand

Alka

Vishvakarma²,

Yadav

et al. 2023

Chemistry & Biodiversity

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Mn(II) and Co(II) complexes of methyl‐(Z)−N′‐carbamothioylcarbamohydrazonate Schiff base ligand were synthesized. The ligand and metal salts were taken in 2 : 1 stoichiometric ratio. All the synthesized complexes were characterized using elemental analysis, molar conductance, magnetic moment and various spectroscopic techniques (FT‐IR, UV/VIS, EPR) techniques. Elemental and spectroscopic results verified bidentate donor nature of the ligand and octahedral geometry of all the complexes. The non‐electrolytic nature of Mn(II) and Co(II) complexes were suggested by conductivity data analysis. In vitro antibacterial (E. coli and S. aureus) and antifungal (C. albicans and C. tropicalis) screening were achieved by employing agar well diffusion method which revealed better antimicrobial activity of Co(II) complexes than Mn(II) complexes. In silico SwissADME study predicted the drug‐likeness probability of ligand and complexes. The interaction of two bacterial proteins (E. coli and S. aureus) with compounds was also analyzed using molecular docking study, which corroborate the in vitro analysis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro, In Silico, ADME and Theoretical Analysis of Mn(II) and Co(II) Complexes Derived from Methyl‐(Z)‐N′‐Carbamothioylcarbamohydrazonate Schiff Base Ligand

Alka

Vishvakarma²,

Yadav

et al. 2023

Chemistry & Biodiversity

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“…Over many years, thiosemicarbazide has been the strong intermediate for developing various novel biomaterials and, therefore, widely utilized in pharmaceutical and medicinal industries. [2,3] The significant biological action [4][5][6][7][8] provided the driving force for exploring the coordination chemistry of these potent ligands. These ligands were also commercially used as analytic reagents, [9,10] catalyst, [11][12][13] molecular-magnetic material, [14] spin-crossover materials, [15] chemosensor to detect Hg 2 + ions, [16] fluoride anions and inorganic cations.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Thiosemicarbazone Coordination Metal Complexes: Synthesis, Characterization, Theoretical analysis, Biological Activity, Molecular Docking and ADME analysis**

Jain

Vishvakarma²,

Singh

et al. 2023

Chemistry & Biodiversity

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Mn(II) and Cu(II) complexes having the formula [M(L)2]X2 of ligand, i. e., 2‐acetyl‐5‐methylfuranthiosemicarbazone were synthesized. Various analytical and spectroscopic techniques described the structure of synthesized complexes. Molar conductance confirmed the electrolytic nature of the complexes. The theoretical study of the complexes explained the structural property and reactivity. The chemical reactivity, interaction and stability of the ligand and metal complexes were studied with the help of global reactivity descriptors. MEP analysis was used to investigate the charge transfer in the ligand. The biological potency was evaluated against two bacteria and two fungi. Complexes demonstrated superior inhibitory action to ligand. The inhibitory effect was also checked at the atomic scale using molecular docking, which confirmed the experimental results. Cu(II) complex was shown to have the most inhibitory effect in experimental and theoretical studies. To check the bioavailability and drug‐likeness, ADME analysis was also done.

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Towards Green Ammonia Synthesis through Plasma‐Driven Nitrogen Oxidation and Catalytic Reduction

et al. 2020

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Ammonia is an industrial large‐volume chemical, with its main application in fertilizer production. It also attracts increasing attention as a green‐energy vector. Over the past century, ammonia production has been dominated by the Haber–Bosch process, in which a mixture of nitrogen and hydrogen gas is converted to ammonia at high temperatures and pressures. Haber–Bosch processes with natural gas as the source of hydrogen are responsible for a significant share of the global CO2 emissions. Processes involving plasma are currently being investigated as an alternative for decentralized ammonia production powered by renewable energy sources. In this work, we present the PNOCRA process (plasma nitrogen oxidation and catalytic reduction to ammonia), combining plasma‐assisted nitrogen oxidation and lean NOx trap technology, adopted from diesel‐engine exhaust gas aftertreatment technology. PNOCRA achieves an energy requirement of 4.6 MJ mol−1 NH3, which is more than four times less than the state‐of‐the‐art plasma‐enabled ammonia synthesis from N2 and H2 with reasonable yield (>1 %).

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Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

Cited by 12 publications

References 83 publications

In Vitro, In Silico, ADME and Theoretical Analysis of Mn(II) and Co(II) Complexes Derived from Methyl‐(Z)‐N′‐Carbamothioylcarbamohydrazonate Schiff Base Ligand

In Vitro, In Silico, ADME and Theoretical Analysis of Mn(II) and Co(II) Complexes Derived from Methyl‐(Z)‐N′‐Carbamothioylcarbamohydrazonate Schiff Base Ligand

Bioactive Thiosemicarbazone Coordination Metal Complexes: Synthesis, Characterization, Theoretical analysis, Biological Activity, Molecular Docking and ADME analysis**

Towards Green Ammonia Synthesis through Plasma‐Driven Nitrogen Oxidation and Catalytic Reduction

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