Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets

Plane shear flow is an important configuration for granular materials. We study the variation of states in plane shear flow, that is, the jam‐flow, slip‐flow, and flow states, in particular the velocities, kinetic energy, contact numbers, and force chains. An open‐source physics‐engine system (BLENDER‐REATICLE) is adopted in this study, which is developed based on the impulse‐based dynamics with the 3D creation suite Blender and the physics engine Bullet. The particles are assumed to be rigid bodies and the elastic energy and gravitational potential energy are neglected in the plane shear flow without gravity. In the phase transition diagram with axial normal stress, shear stress, and solid fraction, the critical‐jamming solid fraction and the critical shear stress are found to increase with the normal stress. We show further that a common power law with the exponent of 0.5 captures well the distributions of particles with low energy. This power law indicates the existence of ergodicity in small‐energy transformation. Moreover, we present a general friction law where the relationships between the effective friction coefficients and the inertial number obey a zero‐order infinitesimal function in the vicinity of the point with Iboundary = 0.

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General friction law for velocity‐stress dependent phase transition in granular flow

Wang

Evans

et al. 2022

Num Anal Meth Geomechanics

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In-situ ultrasonic monitoring for Vat Photopolymerization

Vallabh

Zhang

Zhao

2022

Additive Manufacturing

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Correlation of solid dosage porosity and tensile strength with acoustically extracted mechanical properties

Mack

Cleland³

et al. 2018

International Journal of Pharmaceutics

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Currently, the compressed tablet and its oral administration is the most popular drug delivery modality in medicine. The accurate porosity and tensile strength characterization of a tablet design is vital for predicting its performance such as disintegration, dissolution, and drug-release efficiency upon administration as well as ensuring its mechanical integrity. In current work, a non-destructive contact ultrasonic approach and an associated testing procedure are presented and employed to quantify and relate the acoustically extracted mechanical properties of pharmaceutical compacts to direct porosity and tensile strength measurements. Based on a comprehensive set of experimental data, it is demonstrated how strongly the acoustic wave propagation is modulated and correlated to the tablet porosity and tensile strength of a compact made using spray-dried lactose and microcrystalline cellulose with varying mixture ratios. The effect of mixing ratio on the porosity and tensile strength on the resulting compacts is quantified and, with the acoustic experimental data, mixing ratio is related to the compact ultrasonic characteristics. The ultrasonic techniques provide a rapid, non-destructive means for evaluating compacts in formulation development and manufacturing. The presented approach and data could find critical applications in continuous tablet manufacturing, its real-time quality monitoring, as well as minimizing batch-to-batch quality variations.

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Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets

Cited by 12 publications

References 25 publications

General friction law for velocity‐stress dependent phase transition in granular flow

General friction law for velocity‐stress dependent phase transition in granular flow

In-situ ultrasonic monitoring for Vat Photopolymerization

Correlation of solid dosage porosity and tensile strength with acoustically extracted mechanical properties

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