Correlation of solid dosage porosity and tensile strength with acoustically extracted mechanical properties

Abstract

Currently, the compressed tablet and its oral administration is the most popular drug delivery modality in medicine. The accurate porosity and tensile strength characterization of a tablet design is vital for predicting its performance such as disintegration, dissolution, and drug-release efficiency upon administration as well as ensuring its mechanical integrity. In current work, a non-destructive contact ultrasonic approach and an associated testing procedure are presented and employed to quantify and relate the acoustically extracted mechanical properties of pharmaceutical compacts to direct porosity and tensile strength measurements. Based on a comprehensive set of experimental data, it is demonstrated how strongly the acoustic wave propagation is modulated and correlated to the tablet porosity and tensile strength of a compact made using spray-dried lactose and microcrystalline cellulose with varying mixture ratios. The effect of mixing ratio on the porosity and tensile strength on the resulting compacts is quantified and, with the acoustic experimental data, mixing ratio is related to the compact ultrasonic characteristics. The ultrasonic techniques provide a rapid, non-destructive means for evaluating compacts in formulation development and manufacturing. The presented approach and data could find critical applications in continuous tablet manufacturing, its real-time quality monitoring, as well as minimizing batch-to-batch quality variations.

Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection

“…Hepatocellular carcinoma (HCC) is ranked as the 5th most common cancer worldwide, and the 3rd leading cause of death [1, 2]. Although ultrasound-based surveillance for HCC is applicable in clinical practice, HCC is still diagnosed in the late stage in a significant proportion of patients, for which only palliative treatments such as transarterial chemoembolization (TACE), targeted systemic or hepatic arterial infusion chemotherapies are available.…”