Ultrasoft electronics to monitor dynamically pulsing cardiomyocytes

Lee, Sung-Hoon; Sasaki, Daisuke; Kim, Dongmin; Mori, Mami; Yokota, Tomoyuki; Lee, Hyunjae; Park, SungJun; Fukuda, Kenjiro; Sekino, Masaki; Matsuura, Kiyotaka; Shimizu, Tatsuya; Someya, Takao

doi:10.1038/s41565-018-0331-8

Cited by 208 publications

(197 citation statements)

References 33 publications

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“…Second, the magnetic field decays as the inverse cube of distance limiting the maximum operating range 26 . This study seeks to mitigate the first challenge by achieving a relatively miniaturized, flexible and lightweight design to minimize the invasiveness for epicardial implantation 27,28 . For the second, the power consumption of the pacemaker is substantially reduced by customizing a low-power integrated circuit (IC), which alleviates the need for the incident power and, therefore, extends the distance of operation.…”

mentioning

confidence: 99%

Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Lyu

John²,

Burkland

et al. 2020

Sci Rep

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About 30% of patients with impaired cardiac function have ventricular dyssynchrony and seek cardiac resynchronization therapy (CRT). In this study, we demonstrate synchronized biventricular (BiV) pacing in a leadless fashion by implementing miniaturized and wirelessly powered pacemakers. With their flexible form factors, two pacemakers were implanted epicardially on the right and left ventricles of a porcine model and were inductively powered at 13.56 MHz and 40.68 MHz industrial, scientific, and medical (ISM) bands, respectively. The power consumption of these pacemakers is reduced to µW-level by a novel integrated circuit design, which considerably extends the maximum operating distance. Leadless BiV pacing is demonstrated for the first time in both open-chest and closed-chest porcine settings. The clinical outcomes associated with different interventricular delays are verified through electrophysiologic and hemodynamic responses. The closed-chest pacing only requires the external source power of 0.3 W and 0.8 W at 13.56 MHz and 40.68 MHz, respectively, which leads to specific absorption rates (SARs) 2-3 orders of magnitude lower than the safety regulation limit. This work serves as a basis for future wirelessly powered leadless pacemakers that address various cardiac resynchronization challenges.

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mentioning

confidence: 99%

Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Lyu

John²,

Burkland

et al. 2020

Sci Rep

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“…In order to develop a hybrid tissue based on biodegradable electronics, two recent examples have shown the utilization of electrospun fiber scaffolds as the substrate and dielectric of the electronic mesh. One example described the use of the synthetic polymer polyurethane (Lee et al, 2019), whereas the other used the natural protein albumin . Both examples utilized biodegradable materials that can serve as a scaffold for tissue engineering as well, and when electrospun into fiber form can generate scaffolds that are also flexible and elastic.…”

Section: Tissue-engineered Electronic Hybridsmentioning

confidence: 99%

Engineering Smart Hybrid Tissues with Built-In Electronics

Feiner

2020

iScience

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One of the major hurdles faced in tissue engineering is the inability to monitor and control the function of an engineered tissue following transplantation. Recent years have seen major developments in the field by integrating electronics within engineered tissues. Previously, the most common types of devices integrated into the body used to be pacemakers and deep brain stimulation electrodes that are stiff and non-compliant; the advent of ultra-thin and flexible electronics has brought forth a significant expansion of the field. Recent developments have enabled interfacing electronics onto, into, and within all tissues and organs with minimal adverse reactions. These have introduced the ability to engineer tissues with built-in electronics that allow for remote monitoring and regulation of tissue function. In this review, we discuss the development of technologies that allowed for the formation of tissue-electronics hybrids and give an overview of the existing examples of these hybrid ''cyborg'' tissues.

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“…仿生触觉传感器能够和人体很好地贴合, 高效地采集心脏、骨骼肌、大脑等活动信号 [65,66] , 对于研究神智活动的神经学, 仿生触觉传感器可以作为良好的人机接口, 以检测采集神经信号 [67,68] . 网状的结构可以很好地和人体或人体组织整合, 并保证受检测部位透气、无刺激和束缚感, 因此对受测部位不会造成损伤, 对检测信号也不会产生干扰 [69,70] . 对于临床应表 1 部分相关仿生触觉器件(材料)性能特性 [73] , Liu等人 [74] [76] , 也可以直接集成于皮肤表面监测人的活动信号 [77] .…”

Section: 自愈合既可以通过器件或材料本征特性实现即unclassified