Ultrasmall Superparamagnetic Iron Oxide Labeled Silk Fibroin/Hydroxyapatite Multifunctional Scaffold Loaded With Bone Marrow-Derived Mesenchymal Stem Cells for Bone Regeneration

Liu, Qin; Feng, Longbao; Chen, Zelong; Lan, Yong; Liu, Yu; Li, Dan; Yan, Changqing; Xu, Yu

doi:10.3389/fbioe.2020.00697

Cited by 21 publications

(13 citation statements)

References 41 publications

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“…Amirsalar’s group fabricated multi-component porous magnetic scaffolds via the freeze-drying technique with good porosity and structural similarity to the natural bone that can be used in the treatment of bone cancer [ 55 ]. Xu and co-workers synthesized silk fibroin/hydroxyapatite (SF/HA) scaffolds using the freeze-drying method and combined them with ultramicro SPIONs [ 56 ]. SPION-labeled scaffolds are 3D structures with good porosity and mechanical properties and good thermal stability when used in bone repair, which can promote the adhesion and growth of BMSCs, thus promoting osteogenesis by increasing the activity of alkaline phosphatase (ALP) and upregulating the gene levels of osteoblasts.…”

Section: Biological Scaffolds Assembled With Magnetic Iron Oxide Comp...mentioning

confidence: 99%

Biological Scaffolds Assembled with Magnetic Nanoparticles for Bone Tissue Engineering: A Review

Xue

Wang

et al. 2023

Materials

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Superparamagnetic iron oxide nanoparticles (SPION) are widely used in bone tissue engineering because of their unique physical and chemical properties and their excellent biocompatibility. Under the action of a magnetic field, SPIONs loaded in a biological scaffold can effectively promote osteoblast proliferation, differentiation, angiogenesis, and so on. SPIONs have very broad application prospects in bone repair, bone reconstruction, bone regeneration, and other fields. In this paper, several methods for forming biological scaffolds via the biological assembly of SPIONs are reviewed, and the specific applications of these biological scaffolds in bone tissue engineering are discussed.

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Section: Biological Scaffolds Assembled With Magnetic Iron Oxide Comp...mentioning

confidence: 99%

Biological Scaffolds Assembled with Magnetic Nanoparticles for Bone Tissue Engineering: A Review

Xue

Wang

et al. 2023

Materials

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“…Bones generally possess an interconnected cellular network, with a porosity ∼80%, fracture toughness ∼3 MPa, compression strength 5 MPa, etc. Recently, researchers have developed various techniques for creating porosity in the dense HAp coupled with good mechanical strength. ,− Conventional techniques used for fabricating porous HAp-based scaffolds include freeze-drying, electrospinning, solvent casting, and 3D printing …”

Section: Current Status Of Hap Coatings/scaffoldsmentioning

confidence: 99%

Multifunctional Hydroxyapatite Composites for Orthopedic Applications: A Review

George

Nayak

Singh

et al. 2022

ACS Biomater. Sci. Eng.

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Being a bioactive material, hydroxyapatite (HAp) is regarded as one of the most attractive ceramic biomaterials for bone and hard-tissue replacement and regeneration. Despite its substantial biocompatibility, osteoconductivity, and compositional similarity to that of bone, the employment of HAp is still limited in orthopedic applications due to its poor mechanical (low fracture toughness and bending strength) and antibacterial properties. These significant challenges lead to the notion of developing novel HAp-based composites via different fabrication routes. HAp, when efficaciously combined with functionally graded materials and antibacterial agents, like Ag, ZnO, Co, etc., form composites that render remarkable crack resistance and toughening, as well as enhance its bactericidal efficacy. The addition of different materials and a fabrication method, like 3D printing, greatly influence the porosity of the structure and, in turn, control cell adhesion, thereby enabling biological fixation of the material. This article encompasses an elaborate discussion on different multifunctional HAp composites developed for orthopedic applications with particular emphasis on the incorporation of functionally graded materials and antibacterial agents. The influence of 3D printing on the fabrication of HAp-based scaffolds, and the different in vitro and in vivo studies conducted on these, have all been included here. Furthermore, the present review not only provides insights and broad understanding by elucidating recent advancements toward 4D printing but also directs the reader to future research directions in design and application of HAp-based composite coatings and scaffolds.

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“…By coating core-shell structured HA on SPIONs (SPIO@HA), Li et al ( Li M. et al, 2021 ) discovered it could target osteoclastogenesis and osteogenesis. A multifunctional scaffold of filamentous protein/hydroxyapatite scaffold combined with ultra-small SPIONs (USPIO) doped with BMSCs promotes osteogenic differentiation of SCs and allows for osteogenic differentiation non-invasive monitoring of bone regeneration by quantitative MRI ( Liu Q. et al, 2020 ). Moreover, oleic acid-modified IONPs (IO-OA NPs) and PLGA were used to produce homogeneous magnetic nanocomposites, which showed good mechanical properties and enhanced osteogenic differentiation ( Hao et al, 2019 ).…”

Section: Application Of Iron Oxide Nanoparticles In Bone Regenerationmentioning

confidence: 99%

Hope for bone regeneration: The versatility of iron oxide nanoparticles

Wang

Xie

et al. 2022

Front. Bioeng. Biotechnol.

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Although bone tissue has the ability to heal itself, beyond a certain point, bone defects cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration. Iron oxide nanoparticles (IONPs) are a magnetic material because of their excellent properties, which enable them to play an active role in bone regeneration. This paper reviews the application of IONPs in bone tissue regeneration in recent years, and outlines the mechanisms of IONPs in bone tissue regeneration in detail based on the physicochemical properties, structural characteristics and safety of IONPs. In addition, a bibliometric approach has been used to analyze the hot spots and trends in the field in order to identify future directions. The results demonstrate that IONPs are increasingly being investigated in bone regeneration, from the initial use as magnetic resonance imaging (MRI) contrast agents to later drug delivery vehicles, cell labeling, and now in combination with stem cells (SCs) composite scaffolds. In conclusion, based on the current research and development trends, it is more inclined to be used in bone tissue engineering, scaffolds, and composite scaffolds.

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Ultrasmall Superparamagnetic Iron Oxide Labeled Silk Fibroin/Hydroxyapatite Multifunctional Scaffold Loaded With Bone Marrow-Derived Mesenchymal Stem Cells for Bone Regeneration

Cited by 21 publications

References 41 publications

Biological Scaffolds Assembled with Magnetic Nanoparticles for Bone Tissue Engineering: A Review

Biological Scaffolds Assembled with Magnetic Nanoparticles for Bone Tissue Engineering: A Review

Multifunctional Hydroxyapatite Composites for Orthopedic Applications: A Review

Hope for bone regeneration: The versatility of iron oxide nanoparticles

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