Ultrasmall MoS2 nanodots-wrapped perfluorohexane nanodroplets for dual-modal imaging and enhanced photothermal therapy

Yuan, Anna; Zhang, Yuping; Fang, Guiting; Chen, Weijian; Zeng, Xiangbo; Zhou, Haibo; Cai, Huaihong; Zhong, Xing

doi:10.1016/j.colsurfb.2021.111880

Cited by 6 publications

(6 citation statements)

References 30 publications

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“…Additionally, the defect vacancies of MoS 2 nanosheets can be encapsulated by polymers (such as HA, PEG, PEI, and CS), forming a C─S bond, which can enhance the drug release and be used in combination with photothermal and chemotherapy for cancer therapy. 243 , 244 , 245 Dong et al. 246 prepared MoS 2 –PEI–HA based on MoS 2 nanoparticles.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

“…They utilized the property of MoS 2 to couple with thiol through forming S─S bonds and realized the redox/NIR dual response for cancer therapy based on multifunctional MoS 2 nanoparticles. Additionally, the defect vacancies of MoS 2 nanosheets can be encapsulated by polymers (such as HA, PEG, PEI, and CS), forming a C─S bond, which can enhance the drug release and be used in combination with photothermal and chemotherapy for cancer therapy 243–245 . Dong et al 246 .…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

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Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…It is often used in medical imaging research and is applied to nanomaterials to solve the defects of oxygen depletion in the microenvironment of the biofilm. It can reduce the group inductance among bacteria, and the released oxygen can enhance the photodynamic effect. − However, the phase transition may occur before reaching the target site, so new approaches must be explored to improve the stability of PFH. Ordinary photosensitizers often distress researchers because of their poor water solubility, whereas meso -tetra(4-carboxyphenyl) porphine (TCPP) not only has good photosensitizing properties but also can produce 1 O 2 at specific NIR wavelengths.…”

Section: Introductionmentioning

confidence: 99%

Performance and Mechanism of Self-Oxygenated Perfluorohexane Nanosystem for Combined Photothermal/Photodynamic Bacterial Inhibition

Dong,

Jin,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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Biofilms are responsible for most bacterial infections and significantly threaten human health. Designing effective and less harmful materials to inhibit and remove biofilms remains a significant challenge. Complex biofilm structures make conventional antibiotic treatments ineffective, and in recent years, photothermal therapy (PTT) and photodynamic therapy (PDT) have attracted attention for their ability to treat drug-resistant bacterial infections effectively. Therefore, a synergistic nanoantimicrobial system (PFH/TCPP@SL@PDA) enhances the effect through PTT and PDT. It is synthesized by loading mesotetra(4-carboxyphenyl) porphine (TCPP) on soybean lecithin (SL), further coating perfluorohexane (PFH) and finally coating polydopamine (PDA) on the outer layer. The designed nanoantimicrobial system alleviates the hypoxic properties of the biofilm microenvironment by loading oxygen and enhances the effect of PDT to generate more reactive oxygen species. It significantly enhanced biofilm permeability and improved antimicrobial properties, with over 95% inhibition of multidrug-resistant (MDR) Escherichia coli and MDR Staphylococcus aureus while inhibiting and removing over 90% of biofilms. PDA not only acts as a good nanoshell but also induces relatively mild PTT and can facilitate the reaction of PDT. PFH/TCPP@SL@PDA has good biocompatibility, and the hemolysis test showed less than 5% hemolysis of erythrocytes, effectively relieving inflammatory symptoms and accelerating wound healing in mice model. In conclusion, this study provides an efficient and safe combined therapeutic strategy for the bacterial inhibition, suppression, and removal of biofilms.

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“…Selective localization of synergistic therapy in tumors is also critical for an effective cancer treatment. The researchers have already explored many methods to enhance the accuracy and efficiency of selective localization in the course of treatment, such as magnetic targeting, molecular targeting, imaging-guidance, and so on. – In particular, the magnetic targeting, which can be achieved by the involvement of Gd NPs in the treatment platform, can not only get the physical position of drugs but also realize the magnetic resonance (MR) imaging-guided therapy effect simultaneously. – Notably, another advantage of magnetic targeting over molecular targeting methods is no dependency on the specific receptor expression (such as the receptor expression variation in normal tissues or the patient-to-patient differentiation). – Fluorescence (FL) imaging is a good imaging method that not only reflects the location and size of the tumor but also monitors the flow of the entire NPs in the blood of the mice. , Chlorin e6 (Ce6) is a good fluorescent reagent that can also be used as a PDT reagent for FL imaging …”

Section: Introductionmentioning

confidence: 99%

α-Fe₂O₃@Au-PEG-Ce6-Gd Nanoparticles as Acidic H₂O₂-Driven Oxygenators for Multimodal Imaging and Synergistic Tumor Therapy

et al. 2023

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Nanoparticles with visual imaging capabilities and synergistic therapeutics have a bright future in antitumor applications. However, most of the current nanomaterials lack multiple imagingguided therapeutic capabilities. In this study, a novel enhanced photothermal photodynamic antitumor nanoplatform with photothermal imaging, fluorescence (FL) imaging, and MRI-guided therapeutic capabilities was constructed by grafting gold, dihydroporphyrin Ce6, and Gd onto α-iron trioxide. This antitumor nanoplatform can convert NIR light into local hyperthermia at a temperature of up to 53 °C under NIR light irradiation, while Ce6 can generate singlet oxygen, which further synergizes the tumor-killing effect. At the same time, α

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Ultrasmall MoS2 nanodots-wrapped perfluorohexane nanodroplets for dual-modal imaging and enhanced photothermal therapy

Cited by 6 publications

References 30 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

Performance and Mechanism of Self-Oxygenated Perfluorohexane Nanosystem for Combined Photothermal/Photodynamic Bacterial Inhibition

α-Fe₂O₃@Au-PEG-Ce6-Gd Nanoparticles as Acidic H₂O₂-Driven Oxygenators for Multimodal Imaging and Synergistic Tumor Therapy

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Ultrasmall MoS2 nanodots-wrapped perfluorohexane nanodroplets for dual-modal imaging and enhanced photothermal therapy

Cited by 6 publications

References 30 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

Performance and Mechanism of Self-Oxygenated Perfluorohexane Nanosystem for Combined Photothermal/Photodynamic Bacterial Inhibition

α-Fe2O3@Au-PEG-Ce6-Gd Nanoparticles as Acidic H2O2-Driven Oxygenators for Multimodal Imaging and Synergistic Tumor Therapy

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α-Fe₂O₃@Au-PEG-Ce6-Gd Nanoparticles as Acidic H₂O₂-Driven Oxygenators for Multimodal Imaging and Synergistic Tumor Therapy