Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery

Yu, Luodan; Chen, Yu; Han, Lin; Du, Wenxian; Chen, Hangrong; Shi, Jianlin

doi:10.1016/j.biomaterials.2018.01.046

Cited by 132 publications

(108 citation statements)

References 58 publications

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“…The synthesis of MON was carried out using a simple sol–gel methodology . Typically, a mixture of CTAC (20 g, 10 wt%) and TEA aqueous solution (0.8 g 10 wt%) was stirred at 90 °C for 30 min, and then 1 mL TEOS was added.…”

Section: Methodsmentioning

confidence: 99%

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Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Yao

Peng

et al. 2020

Adv Healthcare Materials

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Multiple drug resistance (MDR) exhibited by cancer cells and low intratumor accumulation of chemotherapeutics are the main obstacles in cancer chemotherapy. Herein, the preparation of a redox‐responsive sulfur dioxide (SO2)‐releasing nanosystem, with high SO2‐loading capacity, aimed at improving the treatment efficacy of cancers exhibiting MDR is described. The multifunctional nanomedicine (MON‐DN@PCBMA‐DOX) is designed and constructed by coating mesoporous organosilica nanoparticles with a zwitterionic polymer, poly(carboxybetaine methacrylate) (PCBMA), which can concurrently load SO2 prodrug molecules (DN, 2,4‐dinitrobenzenesulfonylchloride) and chemotherapeutics (DOX, doxorubicin). The generated SO2 molecules can sensitize cells to chemotherapy and overcome the MDR by downregulating the expression of P‐glycoprotein. Furthermore, the PCBMA coating prolongs the blood circulation time of the inner core, leading to an increased intratumor accumulation of the nanomedicine. Owing to the prolonged blood circulation, enhanced tumor accumulation, and SO2 sensitization of cells to chemotherapy, the nanomedicine exhibits excellent tumor suppression with a tumor inhibition rate of 94.8%, and might provide a new platform for cancer therapy.

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Section: Methodsmentioning

confidence: 99%

“…The cytotoxicity of MON@PCBMA, free DOX, MON‐DN@PCBMA, and MON‐DN@PCBMA‐DOX was measured as previously described . First, MCF‐7 and MCF‐7/ADR cells were seeded into a 96‐well plate.…”

Section: Methodsmentioning

confidence: 99%

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Yao

Peng

et al. 2020

Adv Healthcare Materials

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“…For example, although rapid clearance of ultrasmall NPs (<8 nm, the renal clearance threshold) via the renal pathway reduces toxicity concerns, it also impedes sufficient accumulation at the tumor site for effective tumor inhibition . On the other hand, engineering biodegradable NPs with tailored in vivo degradation and PK profiles remains a significant technological impediment . Despite advantages such as enhanced loading and co‐delivery of both small and macromolecular drugs, long‐term and comprehensive in vivo studies documenting their tumor uptake, drug delivery, and successful hepatobiliary clearance are yet to be explored.…”

Section: Introductionmentioning

confidence: 99%

Size‐Optimized Ultrasmall Porous Silica Nanoparticles Depict Vasculature‐Based Differential Targeting in Triple Negative Breast Cancer

Goel

Ferreira

Dogra

et al. 2019

Small

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Rapid sequestration and prolonged retention of intravenously injected nanoparticles by the liver and spleen (reticuloendothelial system (RES)) presents a major barrier to effective delivery to the target site and hampers clinical translation of nanomedicine. Inspired by biological macromolecular drugs, synthesis of ultrasmall (diameter ≈12–15 nm) porous silica nanoparticles (UPSNs), capable of prolonged plasma half‐life, attenuated RES sequestration, and accelerated hepatobiliary clearance, is reported. The study further investigates the effect of tumor vascularization on uptake and retention of UPSNs in two mouse models of triple negative breast cancer with distinctly different microenvironments. A semimechanistic mathematical model is developed to gain mechanistic insights into the interactions between the UPSNs and the biological entities of interest, specifically the RES. Despite similar systemic pharmacokinetic profiles, UPSNs demonstrate strikingly different tumor responses in the two models. Histopathology confirms the differences in vasculature and stromal status of the two models, and corresponding differences in the microscopic distribution of UPSNs within the tumors. The studies demonstrate the successful application of multidisciplinary and complementary approaches, based on laboratory experimentation and mathematical modeling, to concurrently design optimized nanomaterials, and investigate their complex biological interactions, in order to drive innovation and translation.

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“…The MnO 2 ‐hybrid nanoparticle with the noncovalent coordination interaction possessed intrinsic biodegradability, which was cleared through feces and urine (F. Liu et al, ). Organic degradable mesoporous silica nanoparticles were the resolution of traditional mesoporous silica nanoparticles (MSN), due to their controllable degradation characteristic triggered by the tumor environment (Song et al, ; Y. Yang et al, ; L. Yu et al, ).…”

Section: Perspectivementioning

confidence: 99%

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Liao

Jia

et al. 2019

WIREs Nanomed Nanobiotechnol

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Cancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine enters the target tumor site, it can release therapeutic agents in an effective manner. Accordingly, various nanomedicines have been developed to enhance the efficiency of cancer therapy and minimize the systematic toxicity. Here, we provide an overview and discuss the different types of responsive nanomedicines including physically, chemically, biologically, dual, and multi‐responsive nanomedicines, for the in situ release of cargos in recent years. We propose critical considerations that must be considered for the design of excellent stimuli‐nanomedicine. Furthermore, the possible directions for the development of successful stimuli‐responsive (smart) nanomedicine are highlighted. With the development of responsive nanomedicines, precise and personalized nanomedicine will be realized with great promise in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery

Cited by 132 publications

References 58 publications

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Size‐Optimized Ultrasmall Porous Silica Nanoparticles Depict Vasculature‐Based Differential Targeting in Triple Negative Breast Cancer

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

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