Ultrasmall Fluorescent Silica Nanoparticles as Intraoperative Imaging Tools for Cancer Diagnosis and Treatment

Bradbury, Michelle S.; Pauliah, Mohan; Wiesner, Ulrich

doi:10.1007/978-1-4939-2326-7_13

Cited by 9 publications

(1 citation statement)

References 34 publications

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“…[19][20][21][22] Furthermore, the ultrasmall size (< 10 nm) of C and C′ dots has shown promise for cancer diagnostics and treatment, 23,24 addressing important safety concerns as particles demonstrate rapid renal clearance profiles leading to low off-target accumulation and high target-to-background ratios. 10,17,25,26 In addition to medical applications, the combined particle brightness and ability to add reactive groups to the PEG shell, silica core, or both, has led to their application as rigid tracer particles, e.g. for studying polymer (hydrogel) physics and diffusion 27,28 and surface functionalization.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Measure of the Size Dispersity in Ultrasmall Fluorescent Organic–Inorganic Hybrid Core–Shell Silica Nanoparticles by Small-Angle X-ray Scattering

Barteau

Kohle

et al. 2019

Chem. Mater.

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Small-angle X-ray scattering (SAXS) was performed on dispersions of ultrasmall (d < 10 nm) fluorescent organic-inorganic hybrid core-shell silica nanoparticles synthesized in aqueous solutions (C′ dots) by using an oscillating flow cell to overcome beam induced particle degradation. Form factor analysis and fitting was used to determine the size and size dispersity of the internal silica core containing covalently encapsulated fluorophores. The structure of the organic poly(ethylene glycol) (PEG) shell was modelled as a monodisperse corona containing concentrated and semi-dilute regimes of decaying density and as a simple polydisperse shell to determine the bounds of dispersity in the overall hybrid particle. C′ dots containing single growth step silica cores have dispersities of 0.19-0.21; growth of additional silica shells onto the core produces a thin, dense silica layer, and increases the dispersity to 0.22-0.23. Comparison to FCS and DLS measures of size shows good agreement with SAXS measured and modelled sizes and size dispersities. Finally, comparison of a set of same sized and purified particles demonstrates that SAXS is sensitive to the skewness of the gel permeation chromatography elugrams of the original as-made materials. These and other insights provided by quantitative SAXS assessments may become useful for generation of robust nanoparticle design criteria necessary for their successful and safe use, for example in nanomedicine and oncology applications.

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Section: Introductionmentioning

confidence: 99%

Quantitative Measure of the Size Dispersity in Ultrasmall Fluorescent Organic–Inorganic Hybrid Core–Shell Silica Nanoparticles by Small-Angle X-ray Scattering

Barteau

Kohle

et al. 2019

Chem. Mater.

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Gold Nanoparticle Transport in the Injured Kidneys with Elevated Renal Function Biomarkers

Ning,

Zhong,

Cai

et al. 2024

Advanced Materials

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Renal function biomarkers such as serum blood urea nitrogen (BUN) and creatinine (Cr) serve as key indicators for guiding clinical decisions before administering kidney‐excreted small‐molecule agents. With engineered nanoparticles increasingly designed to be renally clearable to expedite their clinical translation, understanding the relationship between renal function biomarkers and nanoparticle transport in diseased kidneys becomes crucial to their biosafety in future clinical applications. In this study, renal‐clearable gold nanoparticles (AuNPs) are used as X‐ray contrast agents to noninvasively track their transport and retention in cisplatin‐injured kidneys with varying BUN and Cr levels. The findings reveal that AuNP transport is significantly slowed in the medulla of severely injured kidneys, with BUN and Cr levels elevated to 10 times normal. In mildly injured kidneys, where BUN and Cr levels only four to five times higher than normal, AuNP transport and retention are not predictable by BUN and Cr levels but correlate strongly with the degree of tubular injury due to the formation of gold–protein casts in the Henle's loop of the medulla. These results underscore the need for caution when employing renal‐clearable nanomedicines in compromised kidneys and highlight the potential of renal‐clearable AuNPs as X‐ray probes for assessing kidney injuries noninvasively.

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Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs

Davis¹,

Thakkar²,

Maniruzzaman³

et al. 2022

Formulating Poorly Water Soluble Drugs

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Ultrasmall Fluorescent Silica Nanoparticles as Intraoperative Imaging Tools for Cancer Diagnosis and Treatment

Cited by 9 publications

References 34 publications

Quantitative Measure of the Size Dispersity in Ultrasmall Fluorescent Organic–Inorganic Hybrid Core–Shell Silica Nanoparticles by Small-Angle X-ray Scattering

Quantitative Measure of the Size Dispersity in Ultrasmall Fluorescent Organic–Inorganic Hybrid Core–Shell Silica Nanoparticles by Small-Angle X-ray Scattering

Gold Nanoparticle Transport in the Injured Kidneys with Elevated Renal Function Biomarkers

Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs

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