Ultrasmall AgBiSe<sub>2</sub> nanodots for CT/thermal imaging-guided photothermal tumor therapy in the NIR-II biowindow

Zhang, Jingge; Ha, Enna; Li, Danyang; Wang, Luyang; Hu, Junqing

doi:10.1039/d2nr02908a

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Synthesis and Characterization Of Co-fese 2 Nanozymes1

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2023

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Cited by 2 publications

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“…The peaks located at 54.1 and 53.5 eV matched well with Se 3d 3/2 and Se 3d 5/2 , respectively. 42,43 The peaks centered at 719.2 and 706.8 eV were ascribed to the binding energy of Fe 2p 1/2 and Fe 2p 3/2 , reflecting the existence of Fe 2+ . The binding energy peaks of Fe 3+ were located at 711.4 and 724.5 eV.…”

Section: Synthesis and Characterization Of Co-fese 2 Nanozymesmentioning

confidence: 99%

Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Zhang¹,

Ha²,

Li³

et al. 2023

J. Mater. Chem. B

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Section: Synthesis and Characterization Of Co-fese 2 Nanozymesmentioning

confidence: 99%

Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Zhang¹,

Ha²,

Li³

et al. 2023

J. Mater. Chem. B

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“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy

Li,

Ha,

Zhou

et al. 2023

Advanced Materials

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Multienzyme‐mimicking redox nanozymes capable of efficient reactive oxygen species (ROS) generation and cellular homeostasis disruption are highly pursued for cancer therapy. However, it still faces challenges from the complicate tumor microenvironment (TME) and high chance for tumor metastasis. Herein, well‐dispersed PtMnIr nanozymes are designed with multiple enzymatic activities, including catalase (CAT), oxidase (OXD), superoxide dismutase (SOD), peroxidase (POD), and glutathione peroxidase (GPx), which continuously produce ROS and deplete glutathione (GSH) concurrently in an “inner catalytic loop” way. With the help of electrodynamic stimulus, highly active “spark” species (Ir3+ and Mn3+) are significantly increased, resulting in an effective cascade enzymatic and electrodynamic therapy. Moreover, the cyclic generation of ROS can also facilitate ferroptosis and apoptosis in tumor cells, boosting synergistic therapy. Importantly, lung metastasis inhibition is found, which confirms efficient immunotherapy by the combined effect of immunogenic cell death (ICD) and Mn2+‐induced cyclic guanosine monophosphate (GMP)–adenosine monophosphate (AMP) synthase (cGAS)–stimulator of interferon genes (cGAS–STING) pathway, contributing great potential in the treatment of malignant tumors.

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Ultrasmall AgBiSe₂ nanodots for CT/thermal imaging-guided photothermal tumor therapy in the NIR-II biowindow

Abstract: Stimulus-responsive ternary chalcogenide nanomaterials are regarded as promising ‘all-in-one’ nanotheranostics agents, on account of their tunable band structures and multi-metal intrinsic properties. Herein, ultrasmall AgBiSe2 nanodots are prepared by a...

Cited by 2 publications

References 57 publications

Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy

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Ultrasmall AgBiSe2 nanodots for CT/thermal imaging-guided photothermal tumor therapy in the NIR-II biowindow

Abstract: Stimulus-responsive ternary chalcogenide nanomaterials are regarded as promising ‘all-in-one’ nanotheranostics agents, on account of their tunable band structures and multi-metal intrinsic properties. Herein, ultrasmall AgBiSe2 nanodots are prepared by a...

Cited by 2 publications

References 57 publications

Dual enzyme-like Co–FeSe2nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Dual enzyme-like Co–FeSe2nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy

Contact Info

Product

Resources

About

Ultrasmall AgBiSe₂ nanodots for CT/thermal imaging-guided photothermal tumor therapy in the NIR-II biowindow

Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy