Dual enzyme-like Co–FeSe<sub>2</sub>nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Zhang, Jingge; Ha, Enna; Li, Danyang; He, Simai; Wang, Luyang; Hu, Junqing

doi:10.1039/d3tb00220a

Cited by 9 publications

(2 citation statements)

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“…In addition, the GSH depletion capacity of Pt/CeO 2− x S x was detected with 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB). 51 As shown in Fig. 3b, with the increase of the incubation time of Pt/CeO 2− x S x , the characteristic peak decreased significantly, indicating that Pt/CeO 2− x S x had a good GSH consumption capacity based on the reaction of Ce 4+ ions with GSH.…”

Section: Resultsmentioning

confidence: 80%

Defect-rich sonosensitizers based on CeO₂ with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Zheng,

Yin,

et al. 2024

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 80%

Defect-rich sonosensitizers based on CeO₂ with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Zheng,

Yin,

et al. 2024

J. Mater. Chem. B

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“…Based on the excellent photothermal-enhanced enzyme-like catalytic performance and controllable degradation ability of FeSe 2 NSs, 41,44 we further investigated their antitumor performance at the cellular level. First, confocal laser scanning microscopy (CLSM) was employed to observe the cell uptake of FeSe 2 NSs by 4T1 cells (Fig.…”

Section: Resultsmentioning

confidence: 99%

Metastable FeSe₂ nanosheets as a one-for-all platform for stepwise synergistic tumor therapy

Zhang,

Jiang,

Yue

et al. 2024

J. Mater. Chem. B

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“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy

Li,

Ha,

Zhou

et al. 2023

Advanced Materials

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Multienzyme‐mimicking redox nanozymes capable of efficient reactive oxygen species (ROS) generation and cellular homeostasis disruption are highly pursued for cancer therapy. However, it still faces challenges from the complicate tumor microenvironment (TME) and high chance for tumor metastasis. Herein, well‐dispersed PtMnIr nanozymes are designed with multiple enzymatic activities, including catalase (CAT), oxidase (OXD), superoxide dismutase (SOD), peroxidase (POD), and glutathione peroxidase (GPx), which continuously produce ROS and deplete glutathione (GSH) concurrently in an “inner catalytic loop” way. With the help of electrodynamic stimulus, highly active “spark” species (Ir3+ and Mn3+) are significantly increased, resulting in an effective cascade enzymatic and electrodynamic therapy. Moreover, the cyclic generation of ROS can also facilitate ferroptosis and apoptosis in tumor cells, boosting synergistic therapy. Importantly, lung metastasis inhibition is found, which confirms efficient immunotherapy by the combined effect of immunogenic cell death (ICD) and Mn2+‐induced cyclic guanosine monophosphate (GMP)–adenosine monophosphate (AMP) synthase (cGAS)–stimulator of interferon genes (cGAS–STING) pathway, contributing great potential in the treatment of malignant tumors.

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Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Abstract: Nanozymes mediated catalytic therapy can produce toxic reactive oxygen species (ROS) and destroy the metabolic balance of tumor cells, providing a new direction for cancer treatment. However, the catalytic efficiency...

Cited by 9 publications

References 67 publications

Defect-rich sonosensitizers based on CeO₂ with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Defect-rich sonosensitizers based on CeO₂ with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Metastable FeSe₂ nanosheets as a one-for-all platform for stepwise synergistic tumor therapy

“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy

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Dual enzyme-like Co–FeSe2nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Abstract: Nanozymes mediated catalytic therapy can produce toxic reactive oxygen species (ROS) and destroy the metabolic balance of tumor cells, providing a new direction for cancer treatment. However, the catalytic efficiency...

Cited by 9 publications

References 67 publications

Defect-rich sonosensitizers based on CeO2 with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Defect-rich sonosensitizers based on CeO2 with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Metastable FeSe2 nanosheets as a one-for-all platform for stepwise synergistic tumor therapy

“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy

Contact Info

Product

Resources

About

Dual enzyme-like Co–FeSe₂nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy

Defect-rich sonosensitizers based on CeO₂ with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Defect-rich sonosensitizers based on CeO₂ with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

Metastable FeSe₂ nanosheets as a one-for-all platform for stepwise synergistic tumor therapy