Ultrasensitive ratiometric fluorescent probes for Hg(<scp>ii</scp>) and trypsin activity based on carbon dots and metalloporphyrin <i>via</i> a target recycling amplification strategy

Huang, Shan; Yao, Jinhuan; Gan, Ning; Li, Bo; Mu, Pingping; Xiao, Qi

doi:10.1039/d1an02287c

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…The aggregation system causes fluorescence quenching, and the entry of Try hydrolyzes Pro and disperses CQDs, which in turn activates the fluorescence production (Figure 13b) [155]. A fluorescent probe involving tetraphenyl porphyrin tetrasulfonic acid (TPPS) with BSA as the substrate achieved an ultra-low-detection limit of 0.013 ng/mL for trypsin [156].…”

Section: Fluorescence Methodsmentioning

confidence: 99%

Sensing of Digestive Enzymes—Diagnosis and Monitoring of Pancreatitis

Yin,

Cui,

Yang

et al. 2023

Chemosensors

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This paper is a comprehensive review of the techniques for the detection of pancreatic enzymes, which are common biochemical indicators of pancreatitis, including amylase, trypsin, chymotrypsin, elastase, and lipase. Pancreatitis is a disease with self-digestion due to the abnormal activation of digestive enzymes in the pancreas. Hospitalization is often required due to the lack of convenient therapeutic agents. The main recent results are reported in this review, especially the techniques that enable portability and Point-of-Care testing (POCT). This is because timely diagnosis at the early stage and avoiding recurrence after recovery are the keys to treatment. It is also important to reduce the rate of misdiagnosis and to avoid overtreatment. Various detection methods are discussed, with particular attention given to the implementation of chemical sensing and probe design. The new sensing technology for digestive enzymes makes it possible to perform early screening for pancreatitis in remote areas or in one’s own home.

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Section: Fluorescence Methodsmentioning

confidence: 99%

Sensing of Digestive Enzymes—Diagnosis and Monitoring of Pancreatitis

Yin,

Cui,

Yang

et al. 2023

Chemosensors

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“…The detection and quantification of heavy metal ions in the environment are crucial due to their high toxicity and potential adverse effects on ecosystems and human health. Heavy metal ions, such as mercury (Hg 2+ ) [ 86 , 101 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 ], lead (Pb 2+ ) [ 67 , 98 , 106 , 116 , 117 , 118 , 119 ], chromium (Cr 6+ ) [ 120 , 121 , 122 , 123 ], copper (Cu 2+ ) [ 67 , 79 , 92 , 109 , 119 , 124 , 125 , 126 , 127 , 128 , 129 , 130 ], and silver (Ag + ) [ 78 , 117 , 131 , 132 , 133 ], can contaminate water, soil, and air through various industrial processes and human activities. Table 1 summarizes sensing of some heavy metal ions using CD-based ratiometric fluorescence probes.…”

Section: Application In Environmental Monitoringmentioning

confidence: 99%

Advances in Carbon Dot-Based Ratiometric Fluorescent Probes for Environmental Contaminant Detection: A Review

Xing,

Wang,

Wang

2024

Micromachines

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Detecting environmental contaminants is crucial for protecting ecosystems and human health. While traditional carbon dot (CD) fluorescent probes are versatile, they may suffer from limitations like fluctuations in signal intensity, leading to detection inaccuracies. In contrast, ratiometric fluorescent probes, designed with internal self-calibration mechanisms, offer enhanced sensitivity and reliability. This review focuses on the design and applications of ratiometric fluorescent probes based on CDs for environmental monitoring. Our discussion covers construction strategies, ratiometric fluorescence principles, and applications in detecting various environmental contaminants, including organic pollutants, heavy metal ions, and other substances. We also explore associated advantages and challenges and provide insights into potential solutions and future research directions.

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“…Human urine samples and human serum samples were all obtained from healthy volunteers in our lab and treated following our reported processes. 29,30 Human urine samples were centrifuged at 10 000 rpm for 15 min and then ltered through a 0.22 mM lter membrane (Merck Millipore, USA). The pretreated human urine samples were diluted 100-fold with Tris-HCl buffer (50 mM, pH 6.0) before detection.…”

Section: Preparation Of Authentic Samplesmentioning

confidence: 99%

Rapid microwave fabrication of red-carbon quantum dots as fluorescent on–off–on probes for the sequential determination of Fe(iii) ion and ascorbic acid in authentic samples

Huang

Gan

et al. 2023

Anal. Methods

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Ultrasensitive ratiometric fluorescent probes for Hg(ii) and trypsin activity based on carbon dots and metalloporphyrin via a target recycling amplification strategy

Abstract: A convenient and ultrasensitive ratiometric fluorescent probe was innovatively established for Hg(II) detection and trypsin activity evaluation based on carbon dots (CDs) and tetraphenylporphyrin tetrasulfonic acid (TPPS) by using bovine...

Cited by 9 publications

References 45 publications

Sensing of Digestive Enzymes—Diagnosis and Monitoring of Pancreatitis

Sensing of Digestive Enzymes—Diagnosis and Monitoring of Pancreatitis

Advances in Carbon Dot-Based Ratiometric Fluorescent Probes for Environmental Contaminant Detection: A Review

Rapid microwave fabrication of red-carbon quantum dots as fluorescent on–off–on probes for the sequential determination of Fe(iii) ion and ascorbic acid in authentic samples

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