Ultrasensitive Microstring Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules

Abstract

 Users may download and print one copy of any publication from the public portal for the purpose of private study or research.  You may not further distribute the material or use it for any profit-making activity or commercial gain  You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Temperature-Modulated Micromechanical Thermal Analysis with Microstring Resonators Detects Multiple Coherent Features of Small Molecule Glass Transition

“…As discussed later, intrinsic sample properties, such as the viscosity, influence the liquefaction process, and variations of such were therefore purposely excluded. An analysis and discussion of the applicability of MTA to various compounds is a central element of the aforementioned study, which employs the same sampling process [9].…”

“…This includes measurements of the sample's infrared absorption from resonating micromembranes or the probing of thermal characteristics of the sample using string and cantilever-based sensors [2][3][4][5][6][7][8][9][10].…”

“…We have shown the potential of resonating microstrings for the direct solid-state thermal characterization of a variety of samples with a method called Micromechanical Thermal Analysis (MTA) [9]. This instrumental technique is able to probe a small amount of material (typically in the picoto nanogram range) to gain thermal and mechanical responses by tracking the resonance frequency and quality factor of the silicon-rich nitride (SiRN) strings during heating inside a vacuum chamber.…”

“…This includes the discussion of dynamic and static portions of the transition [16]. In this regard, an aim of the study was to further analyze a previously observed two-step change in resonance frequency during the glass transition process of small and large molecule samples [9]. More recently, the Tg has also been used as a go-to transition for investigation and validation in novel physicochemical characterization techniques based on nano-and microresonators [2][3][4][5].…”

Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

“…Moreover, thermal conductivity is an important input parameter in many solid-state models, including models for process flow, e.g., in hot melt extrusion [6,7], or models to help understand the material responses to recently developed analytical techniques [8].…”