Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano‐Bioprobes

Abstract

Ultrasensitive and accurate detection of tumor markers is of vital importance for the screening or diagnosis of cancers at their early stages and for monitoring cancer relapse after surgical resection. Inorganic lanthanide (Ln3+) nanoparticles (NPs), owing to their superior physicochemical characteristics, are regarded as a new generation of luminescent nano‐bioprobes in the field of cancer diagnosis and therapy. In this progress report, a focus is set on our recent efforts on the development of inorganic Ln3+‐NPs as efficient luminescent nano‐bioprobes for the ultrasensitive in vitro biodetection of tumor markers, with an emphasis on the dissolution‐enhanced luminescent bioassay (DELBA), an emerging technique recently developed toward practical medical applications.

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

“…The fast moving field of lanthanide‐containing luminescent nanoparticles has been the subject of many recent reviews covering subjects as diverse as fundamental properties, synthesis, biosensing, bioimaging, drug delivery and theranostics, as well as persistent luminescence nanoparticles, NIR‐emitting nanoparticles, and forensic or other applications . The present review focuses on biological/medical applications and on lighting/displays, two main sectors in which nanomaterials have brought significant advances recently.…”

Diameter-optimized high-order waveguide nanorods for fluorescence enhancement applied in ultrasensitive bioassays

“…[10][11][12] To accomplish high detection sensitivity, diverse organic dyes and inorganic nanoparticles with high quantum yields have been utilized as fluorescent probes. [13][14][15][16][17][18][19][20][21] Considering that the quantum yields of such probes are already > 75%, [19][20][21] further improvement by employing advanced fluorescent probes appears rather limited. An alternative and far more promising strategy to address this challenge would be to develop novel fluorescence enhancement (FE) platforms, which lately have sparked enormous interest.…”

Energy Transfer in Dye‐Coupled Lanthanide‐Doped Nanoparticles: From Design to Application

“…They may also be useful in ultrasensitive detection . As a prominent example, Chen and co‐workers applied dye‐sensitized LnNPs for dissociation‐enhanced luminescent bioassay (DELBA) ,. By integrating hybrid advantages of inorganic LnNPs and organic lanthanide–chelates, the DELBA enables ultrasensitive in vitro detection of various tumor biomarkers with ultrahigh sensitivity.…”