Ultrasensitive Label-Free Biosensor Based on the Graphene-Oxide-Coated-U-Bent Long-Period Fiber Grating Inscribed in a Two-Mode Fiber

Sang, Mei; Wang, Shuang; Xu, Tianhua; Yu, Xun; Liu, Tiegen

doi:10.1109/jlt.2020.3027769

Cited by 18 publications

(10 citation statements)

References 22 publications

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“…(6) A surface-modified H-shaped optical fiber was used to monitor different concentrations of human IgG solutions. After each test, the bonds between human IgG and goat anti-human IgG were broken 10 min by 10 mM NaOH [28,29], and then the Hshaped optical fiber was rinsed with PBS buffer; subsequently, the test for the next concentration started. As shown in Figure 7, the surface modification of the H-shaped optical fiber and the human-IgG detection process is as follows:…”

Section: Resultsmentioning

confidence: 99%

Compact Surface Plasmon Resonance IgG Sensor Based on H-Shaped Optical Fiber

Huang

Wang

et al. 2022

Biosensors

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A compact surface plasmon resonance sensor based on an H-shaped optical fiber is proposed and demonstrated. The H-shaped optical fiber was fabricated experimentally by using hydrofluoric acid to controllably corrode the polarization-maintaining fiber. A satisfactory distance between the outer surface of the fiber and the core can be achieved, and then the surface plasmon resonance effect can be excited by coating a metal film of appropriate thickness on the surface of the fiber. This technology can realize the preparation of multiple samples at one time, compared to the traditional side-polishing technique. The H-shaped optical fiber obtained from corrosion exhibits a high surface quality and short lengths, down to only a few hundred microns. The effects of the proposed H-shaped optical fiber on spectral properties are induced by process parameters, including fiber remaining thickness, coating thickness and fiber length, and were investigated in detail. The prepared sensor was used for the specific detection of human IgG, and the minimum human IgG concentration that the sensor can distinguish is 3.4 μg/mL. Such a compact surface plasmon resonance fiber sensor has the advantages of an easy fabrication, good consistency and low cost, and is expected to be applied in the specific detection of biomarkers.

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Section: Resultsmentioning

confidence: 99%

Compact Surface Plasmon Resonance IgG Sensor Based on H-Shaped Optical Fiber

Huang

Wang

et al. 2022

Biosensors

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“…We compare the IgG sensing sensitivity and anti-environmental interference capability of the proposed HIPFG immunosensor to other reported optical fiber sensors in Table 2 . Although previous reports on IgG sensors are superior in LOD for IgG detection, most of them lack evaluation for environmental factors [ 40 , 41 ], and some of them are sensitive to those factors, which limits their application in mobile equipment and compact devices [ 24 ]. As listed in Table 2 , the sensitivities for torsion, strain, and temperature of HIPFG are significantly smaller than the corresponding values of the previously reported optical fiber IgG sensor, providing stable and reliable sensing performance for IgG sensing.…”

Section: Resultsmentioning

confidence: 99%

“…To address the limitations of conventional techniques for immunosensing, optical fiber sensors, including interferometric fiber-optic sensors [ 14 ], microfiber Bragg gratings [ 15 , 16 , 17 , 18 ], tilted fiber Bragg gratings (TFBG) [ 19 ], surface polarized resonance (SPR) [ 20 , 21 ], and long-period fiber gratings (LPFG) [ 22 , 23 ], were proposed as a biophotonic platform for antibody–antigen interaction monitoring and specific biomolecules’ detection. Among them, LPFGs with various structures and surface modifications were of great interest as immunosensors due to their high sensitivity, outstanding mechanical structure, easy fabrication, good biocompatibility, and free-label detection [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. For example, in 2010, Wang et al utilized a fully distributed LPFG coated with a functional film as an immunosensor and demonstrated that this immunosensor could detect specific antigen–antibody binding without cross-sensitivity to nonspecific binding agents [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…A deposited dual-peak LPFG with graphene oxide (GO) nanosheets has been proposed as a platform for immunosensing and experimentally proved that the LPFG-based sensor had an RI sensitivity of 2538 nm/RIR and ultrahigh anti-IgG detection sensitivity, with a 7 ng/mL detection limit [ 23 ]. Very recently, an IgG sensor consisting of a graphene oxide (GO)-coated-U-bent LPFG inscribed in a two-mode fiber (TMF) was reported with a low limit of detection (23 ng/mL) in the 3–20 μg/mL range [ 24 ]. However, for an immunoassay, most of these optical fiber biosensors need to be combined with extra surface materials and/or multi-fiber architectures, resulting in complicated fabrication procedures that affect stability and weaken coupling strength [ 21 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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All Fiber-Optic Immunosensors Based on Elliptical Core Helical Intermediate-Period Fiber Grating with Low-Sensitivity to Environmental Disturbances

et al. 2022

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An all fiber-optic immunosensor based on elliptical core helical intermediate-period fiber grating (E-HIPFG) is proposed for the specific detection of human immunoglobulin G (human IgG). E-HIPFGs are all-fiber transducers that do not include any additional coating materials or fiber architectures, simplifying the fabrication process and promising the stability of the E-HIPFG biosensor. For human IgG recognition, the surface of an E-HIPFG is functionalized by goat anti-human IgG. The functionalized E-HIPFG is tested by human IgG solutions with a concentration range of 10–100 μg/mL and shows a high sensitivity of 0.018 nm/(μg/mL) and a limit of detection (LOD) of 4.7 μg/mL. Notably, the functionalized E-HIPFG biosensor is found to be insensitive to environmental disturbances, with a temperature sensitivity of 2.6 pm/°C, a strain sensitivity of 1.2 pm/με, and a torsion sensitivity of −23.566 nm/(rad/mm). The results demonstrate the considerable properties of the immunosensor, with high resistance to environmental perturbations, indicating significant potential for applications in mobile biosensors and compact devices.

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“…The structure of this paper is arranged as follows: the second section of the article will analyze and study the preparation technology of the biosensor and the research status of biomedical teaching experimental effect evaluation system; the third section of this paper will focus on the preparation technology and optimization process of the graphene biosensor and give the design process of the biomedical teaching experimental effect evaluation system;the fourth section is mainly the validation experiment and analysis; finally, this paper will be summarized. [21,22]. Relevant European scientists have modified the glassy carbon electrode by the interaction of gold nanoparticles and graphene, so as to realize the high-precision detection of hydrogen peroxide.…”

Section: Introductionmentioning

confidence: 99%

Effect Evaluation of Biomedical Experiment Teaching Based on Intelligent Sensor

2022

Journal of Sensors

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With the continuous development and progress of nanotechnology, its biosensors have been widely used in biomedical experimental teaching, and good experimental results have been achieved. Graphene, as a new nanomaterial with large surface area, good thermal conductivity, and unique electrical conductivity, has unique advantages in the field of biosensor preparation. Based on this, this paper will prepare the electrochemical sensor applied to biomedical experimental teaching based on graphene, optimize the detection sensitivity and detection range of graphene electrochemical sensor based on the corresponding experimental conditions, and improve its corresponding stability and reusability. At the level of electrochemical activity of biosensors, this paper innovatively uses the electric AC impedance method to detect the electrochemical activity, so as to accurately evaluate the key characteristics of biosensors. Based on the preparation of biosensors and the results of biological experiments, this paper will design a network-based biomedical experiment teaching effect evaluation system, and realize the basic functions of teacher-student interaction, teaching effect evaluation, sensor performance evaluation and so on. Based on the above, the electrochemical sensor based on graphene and a conductive polymer solution is actually prepared in this paper. At the same time, the electrocatalysis experiment is carried out based on the sensor, and the experimental teaching effect is systematically evaluated. The experimental results show that the sensitivity of the biosensor proposed in this paper is increased by about 10% compared with the traditional biosensor, the corresponding preparation complexity is reduced by nearly 1/3, and the corresponding reusability is increased by 30%. Therefore, the biomedical experiment teaching effect evaluation system proposed in this paper has good evaluation effect. It can provide accurate reference for the evaluation of biological experiment teaching effect, so it has important value and significance.

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Ultrasensitive Label-Free Biosensor Based on the Graphene-Oxide-Coated-U-Bent Long-Period Fiber Grating Inscribed in a Two-Mode Fiber

Cited by 18 publications

References 22 publications

Compact Surface Plasmon Resonance IgG Sensor Based on H-Shaped Optical Fiber

Compact Surface Plasmon Resonance IgG Sensor Based on H-Shaped Optical Fiber

All Fiber-Optic Immunosensors Based on Elliptical Core Helical Intermediate-Period Fiber Grating with Low-Sensitivity to Environmental Disturbances

Effect Evaluation of Biomedical Experiment Teaching Based on Intelligent Sensor

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