Compact Surface Plasmon Resonance IgG Sensor Based on H-Shaped Optical Fiber

Huang, Yijian; Wang, Ying; Xu, Gaixia; Rao, Xing; Zhang, Jiaxiong; Wu, Xun; Liao, Changrui; Wang, Yiping

doi:10.3390/bios12030141

Cited by 17 publications

(9 citation statements)

References 30 publications

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“…Considering the current noise of 20 nA during the measurement, the limit of detection (LOD) of rabbit IgG can be estimated to be 150 ng/mL, which is comparable to or better than most optical sensors in the literature. For example, H-shaped SPR fiber sensor showed an LOD of 3400 ng/mL for human IgG 41 . Decoration of MoSe2 nanostructures on Au-coated optical fiber obtained an LOD of 330 ng/mL for goat-anti-rabbit IgG 42 .…”

Section: Resultsmentioning

confidence: 99%

“…For example, H-shaped SPR fiber sensor showed an LOD of 3400 ng∕mL for human IgG. 41 Decoration of MoSe 2 nanostructures on Au-coated optical fiber obtained an LOD of 330 ng∕mL for goat-anti-rabbit IgG. 42 Immobilizing half-antibody fragments on an SPR fiber instead of antibody decoration reduced an LOD down to 100 ng∕mL.…”

Section: On-chip Optical Sensing With In Situ Photoelectric Conversionmentioning

confidence: 99%

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In situ photoelectric biosensing based on ultranarrowband near-infrared plasmonic hot electron photodetection

Nan,

Lai,

Peng

et al. 2024

Adv. Photon.

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Narrowband photodetection is an important measurement technique for material analysis and sensing, for example, nondispersive infrared sensing technique. Both photoactive material engineering and nanophotonic filtering schemes have been explored to realize wavelength-selective photodetection, while most devices have a responsive bandwidth larger than 2% of the operating wavelength, limiting sensing performance. Near-infrared photodetection with a bandwidth of less than 0.2% of the operating wavelength was demonstrated experimentally in Au/Si Schottky nanojunctions. A minimum linewidth of photoelectric response down to 2.6 nm was obtained at a wavelength of 1550 nm by carefully tailing the absorptive and radiative loss in the nanostructures. Multiple functions were achieved on chip with the corrugated Au film, including narrowband resonance, light harvesting for sensing and photodetection, and electrodes for hot electron emission. Benefiting from such a unity integration with in situ photoelectric conversion of the optical sensing signal and the ultranarrowband resonance, self-contained on-chip biosensing via simple intensity interrogation was demonstrated with a limit of detection down to 0.0047% in concentration for glucose solution and 150 ng∕mL for rabbit IgG. Promising potential of this technique is expected for the applications in on-site sensing, spectroscopy, spectral imaging, etc.

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Section: Resultsmentioning

confidence: 99%

Section: On-chip Optical Sensing With In Situ Photoelectric Conversionmentioning

confidence: 99%

In situ photoelectric biosensing based on ultranarrowband near-infrared plasmonic hot electron photodetection

Nan,

Lai,

Peng

et al. 2024

Adv. Photon.

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“…The resonant wavelength redshifted (shifted toward longer wavelengths) from 805 nm to 1325 nm nonlinearly, meaning that the sensitivity was accelerated and enhanced with the increase in the surrounding RI. The sensitivity reached 28,100 nm/RIU at around 1.330 of the surrounding RI, which is one order of magnitude higher than conventional silica fiber SPR sensors [35]. After bio-modification, the polymer fiber SPR sensor was immersed in a PBS solution for 20 min to verify its stability.…”

Section: Resultsmentioning

confidence: 99%

A D-Shaped Polymer Optical Fiber Surface Plasmon Resonance Biosensor for Breast Cancer Detection Applications

Wu,

Wang,

Zhang

et al. 2023

Biosensors

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Fiber-optic biosensors have garnered significant attention and witnessed rapid development in recent years owing to their remarkable attributes such as high sensitivity, immunity to electromagnetic interference, and real-time monitoring. They have emerged as a potential tool in the realm of biomarker detection for low-concentration and small molecules. In this paper, a portable and cost-effective optical fiber biosensor based on surface plasmon resonance for the early detection of breast cancer is demonstrated. By utilizing the aptamer human epidermal growth factor receptor 2 (HER2) as a specific biomarker for breast cancer, the presence of the HER2 protein can be detected through an antigen-antibody binding technique. The detection method was accomplished by modifying a layer of HER2 aptamer on the flat surface of a gold-coated D-shaped polymer optical fiber (core/cladding diameter 120/490 μm), of which the residual thickness after side-polishing was about 245 μm, the thickness of the coated gold layer was 50 nm, and the initial wavelength in pure water was around 1200 nm. For low-concentration detection of the HER2 protein, the device exhibited a wavelength shift of ~1.37 nm with a concentration of 1 μg/mL (e.g., 5.5 nM), which corresponded to a limit of detection of ~5.28 nM. Notably, the response time of the biosensor was measured to be as fast as 5 s. The proposed biosensor exhibits the potential for early detection of HER2 protein in initial cancer serum and offers a pathway to early prevention of breast cancer.

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“…Huang et al also reported an H‐shaped optical fiber‐based SPR sensor for the specific detection of H‐IgG on Goat aH‐IgG with a detection limits of 3.4 μg/mL. Zheng et al demonstrated the detection of H‐IgG on Goat aH‐IgG by means of a fiber optic SPR sensor (multimode fiber–noncore fiber‐multimode fiber (MMF‐NCF‐MMF) achieving a limit of detection of 1.75 μg/mL [87–89].…”

Section: Resultsmentioning

confidence: 99%

Multiple protein‐patterned surface plasmon resonance biochip for the detection of human immunoglobulin‐G

Kashyap

Boro

Yasmin

et al. 2023

Journal of Biophotonics

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A portable surface plasmon resonance (SPR) measurement prototype integrated with a multiple protein‐patterned SPR biochip is introduced for label‐free and selective detection of human immunoglobulin‐G (H‐IgG). The polyclonal anti‐H‐IgG antibodies derived from goat, rabbit, and mouse were immobilized through polydimethylsiloxane (PDMS) microchannels to fabricate the patterned SPR biochip. The PDMS surface was functionalized using 3‐aminopropyltrimethoxysilane and bonded to carbodiimide‐activated gold substrates to construct irreversibly bonded hydrophilic microfluidic chip at room temperature. For SPR measurement, a custom‐made system is developed with a high angular scanning accuracy of 0.005° and a wide scanning range of 30°–80° that avoids the conventional requirement of expensive goniometric stages and detector arrays. The SPR biochip immobilized with 750 μg/mL goat anti‐H‐IgG demonstrated detection of H‐IgG with a detection limits of 15 μg/mL, and linear response through a wide concentration range (15–225 μg/mL) of high coefficient of determination (R2 = 0.99661). The selectivity of the sensor was investigated by exposing them to two different non‐specific targets (bovine serum albumin and polyvalent antivenom). The results indicate negligible sensor response towards nonspecific targets (0.25° for 30 μg/mL bovine serum albumin (BSA) and 0.25° for 30 μg/mL polyvalent antivenom) in comparison to H‐IgG (1.5° for 30 μg/mL).

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Compact Surface Plasmon Resonance IgG Sensor Based on H-Shaped Optical Fiber

Cited by 17 publications

References 30 publications

In situ photoelectric biosensing based on ultranarrowband near-infrared plasmonic hot electron photodetection

In situ photoelectric biosensing based on ultranarrowband near-infrared plasmonic hot electron photodetection

A D-Shaped Polymer Optical Fiber Surface Plasmon Resonance Biosensor for Breast Cancer Detection Applications

Multiple protein‐patterned surface plasmon resonance biochip for the detection of human immunoglobulin‐G

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