Ultrasensitive Detection of Ovarian Cancer Biomarker Using Au Nanoplate SERS Immunoassay

Eom, Gayoung; Hwang, Ahreum; Kim, Hongki; Moon, Jeong; Kang, Hyunju; Jung, Juyeon; Lim, Eun‐Kyung; Jeong, Jinyoung; Park, Hyun Gyu; Kang, Taejoon

doi:10.1007/s13206-021-00031-2

Cited by 24 publications

(27 citation statements)

References 56 publications

(53 reference statements)

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“…In a recent study, mRNA delivery systems based on CPP PepFect 14 (PF14) nanoparticles and LNPs were compared to measure detectable reporter protein expression in a xenograft model of ovarian cancer which is one of the most common cancers in women [66]. mRNA-PF14 nanoparticles could endure the in vivo environment of the abdominal cavity where ovarian cancer is usually confined, whereas LNPs could not.…”

Section: Applications For Cancer Therapymentioning

confidence: 99%

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

et al. 2022

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RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptidederived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.

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Section: Applications For Cancer Therapymentioning

confidence: 99%

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

et al. 2022

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“…Ovarian cancer is the second most common malignances after breast cancer in females, with a global incidence of roughly 200 000 cases per year. 1 Unfortunately, most patients are already in the middle and late stages upon primary diagnosis, consequently missing the optimal opportunity for efficient treatment. 2 As a result, its early diagnosis and treatment prove feasibility to prevent such cancer.…”

Section: ■ Introductionmentioning

confidence: 99%

Dual-Mode Photoelectrochemical and Electrochemical Immunosensors for Human Epididymis Protein 4 Based on SPR-Promoted Au Nanoparticle/CdS Nanosheet Heterostructures

Wei

Wang

Zheng

et al. 2022

ACS Appl. Nano Mater.

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As a promising biomarker, human epididymis protein 4 (HE4) shows wide applications for early diagnosis and therapy of ovarian cancer. Herein, heterostructured Au nanoparticles/CdS nanosheet (Au NPs/CdS NS) were initially constructed by two-step electrodeposition and used to build photoelectrochemical (PEC) and electrochemical (EC) dual-mode immunosensors for the detection of HE4. As one of appealing properties, surface Plasmon resonance (SPR) effects of Au NPs endowed the Au NPs/ CdS NS heterostructures with highly enhanced PEC and EC signals upon light irradiation, which were gradually weakened by elevating the HE4 concentrations. Under the optimal conditions, the dual-mode sensor displayed wider linear ranges of 0.01−100 and 0.01−200 ng mL −1 for PEC and EC modes, respectively. The detection limits were 1.084 and 1.188 pg mL −1 for PEC and EC detections, respectively. This sensing platform holds great potential for the analysis of other biomarkers in the clinical field.

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“…However, one layer of carbon, called graphene, shows powerful features, such as being harder than diamond, lighter than aluminum, and tougher than steel [ 5 ], which enabled applications of graphene in the coating, electronics, sensors, biotechnology, and so on. In addition to graphene, various nanomaterial types were discovered and screened, such as silver, copper, gold, iron, cobalt oxide, and titanium dioxide that boosted development of nanotechnology [ 6 , 7 , 8 ]. Additionally, different structures of nanomaterials were developed, such as fullerene, nanofibers, nanotubes, nanowires, perovskites, and polymers [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Nanotechnology-Based Approaches for Food Monitoring

et al. 2022

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Throughout the food supply chain, including production, storage, and distribution, food can be contaminated by harmful chemicals and microorganisms, resulting in a severe threat to human health. In recent years, the rapid advancement and development of nanotechnology proposed revolutionary solutions to solve several problems in scientific and industrial areas, including food monitoring. Nanotechnology can be incorporated into chemical and biological sensors to improve analytical performance, such as response time, sensitivity, selectivity, reliability, and accuracy. Based on the characteristics of the contaminants and the detection methods, nanotechnology can be applied in different ways in order to improve conventional techniques. Nanomaterials such as nanoparticles, nanorods, nanosheets, nanocomposites, nanotubes, and nanowires provide various functions for the immobilization and labeling of contaminants in electrochemical and optical detection. This review summarizes the recent advances in nanotechnology for detecting chemical and biological contaminations in the food supply chain.

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Ultrasensitive Detection of Ovarian Cancer Biomarker Using Au Nanoplate SERS Immunoassay

Cited by 24 publications

References 56 publications

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

Dual-Mode Photoelectrochemical and Electrochemical Immunosensors for Human Epididymis Protein 4 Based on SPR-Promoted Au Nanoparticle/CdS Nanosheet Heterostructures

Recent Progress in Nanotechnology-Based Approaches for Food Monitoring

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