Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor

Abstract

The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry (DPV) technique was proposed for the direct quantitative determination of FA in Angelica sinensis and spiked human urine samples for the first time. The dependence of the intensities of currents and potentials on nature of the supporting electrolyte, pH, scan rate, and concentration was investigated. Under optimal conditions, the proposed sensor exhibited excellent electrochemical sensitivity to FA, and the oxidation peak current was proportional to FA concentration in the range of 8.95 × 10−8 M ~5.29 × 10−5 M, with a relatively low detection limit of 4.42 × 10−8 M. This fabricated sensor also displayed acceptable reproducibility, long-term stability, and high selectivity with negligible interferences from common interfering species. Besides, it was applied to detect FA in Angelica sinensis and biological samples with satisfactory results, making it a potential alternative tool for the quantitative detection of FA in pharmaceutical analysis.

Diversity of fungal feruloyl esterases: updated phylogenetic classification, properties, and industrial applications

“…The spectrophotometric assay is widely accepted, even though there is a concern about the spectral overlapping between substrate and product, e.g., methyl substrates and their aromatic acids. Recently, other methods have been developed such as high-performance thin layer chromatography and electrochemical sensor for rapid detection of ferulic acid which may be useful for enzymatic screening [73, 74]. …”

Voltammetric Determination of Ferulic Acid Using Polypyrrole-Multiwalled Carbon Nanotubes Modified Electrode with Sample Application

“…Ferulic acid plays a major role in protecting cell constituents; therefore, its longer circulation in the blood stream is of great interest. Moreover, FA is actively used as an anti-inflammatory, anti-aging, and antithrombotic drug [ 1 ]. Additionally, it alleviates oxidative stress as well as decreases glucose levels in diabetic rats [ 2 ].…”

“…Moreover, a rapid electrochemical detection of ferulic acid using a graphene sensor was also introduced [ 11 ]. For the direct quantitative determination of FA, a clever and more sensitive sensor based on a poly(diallyldimethylammoniumchloride) functionalized graphene-modified GCE was introduced [ 1 ]. Nevertheless, it remains a fruitful challenge to build an electrochemical sensor based on novel nano-materials for performing effortless, sensitive, and fast detection of ferulic acid.…”

Construction of a highly sensitive NADH sensing platform based on PDDA-rGO nanocomposite modified electrode

“…For PDDA-rGO, the characteristic absorption bands of the oxygenic groups decreased, confirming the reduction of GO. Moreover, the spectrum of PDDA-rGO exhibits typical peaks at 2924 cm −1 (CH n ), 1463 cm −1 (CH 2 ), and 1113 cm −1 (C-N) which are corresponding to the characteristic bands of PDDA, indicating the presence of PDDA in graphene nanosheets [32,33].…”