Ultrasensitive Detection of Carcinoembryonic Antigen by Chitosan/Polythiophene/CdTe Electrochemical Biosensor

Wang, Jiajia; Hua, Xinyu; Jin, Baokang

doi:10.1021/acsomega.2c05950

Cited by 12 publications

(4 citation statements)

References 63 publications

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“…The interaction of [Fe(CN) 6 ] 4-/3species with PTh, i.e., an n-type conducting polymer increases the effective resistance/impedance of PTh due to electrostatic repulsions. 27 MIP, owing to the presence of imprints or cavities, provides a more diffusible surface for [Fe(CN) 6 ] 4-/3species, thereby enhancing the interactions of [Fe(CN) 6 ] 4-/3ions on the surface and within the polymer imprints and significantly increasing the impedance as compared to NIP. Thus, EIS also validates the mechanism of interaction of MIP and NIP receptors with the standard redox solution with MIP showing greater diffusion-based interactions compared to NIP, which is attributed to the presence of imprints or cavities.…”

Section: Resultsmentioning

confidence: 99%

Non-Enzymatic Electrochemical Sensors for Accurate and Accessible Uric Acid Detection

Shahzad,

Ajmal,

Afzal

2023

J. Electrochem. Soc.

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Gout arthritis, a painful condition characterized by the accumulation of uric acid (UA) crystals in the joints, necessitates the development of efficient and accessible diagnostic methods. In this study, we present the design and fabrication of non-enzymatic electrochemical sensors based on molecularly imprinted conducting polymer nanostructures for the selective detection and monitoring of UA. To overcome the limitations of current point-of-care (POC) diagnostics, we developed a disposable voltammetric sensor capable of selectively and accurately analyzing UA concentrations at room temperature and pH 7.4. The sensor utilizes a selective polythiophene layer, deposited on disposable screen-printed electrodes, for the reversible binding and recognition of UA. Extensive electrochemical measurements employing electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry demonstrate excellent UA sensing performance in the wider concentration range of 1–500 μM using a standard redox solution with 2.91 µA/cm2·µM sensitivity, 354 nM detection limits, and substantial selectivity over common interferents. The sensor is capable of analyzing complex mixtures such as human saliva with 90.4% recovery of the spiked UA concentration. This highly sensitive and cost-efficient electrochemical sensor offers great promise for POC testing, disease monitoring, and predicting treatment outcomes related to gout arthritis.

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Section: Resultsmentioning

confidence: 99%

Non-Enzymatic Electrochemical Sensors for Accurate and Accessible Uric Acid Detection

Shahzad,

Ajmal,

Afzal

2023

J. Electrochem. Soc.

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Section: Introductionmentioning

confidence: 99%

“…3,4 Carcinoembryonic antigen (CEA), a glycoprotein originally discovered in colon and fetal intestinal tissues, is an important tumor marker in the screening and diagnosis of some cancers, including tumors in the colon, stomach and lungs. 5 Therefore, the sensitive detection of CEA plays a major role in evaluating cancer severity, disease progression, monitoring and prognosis. 6,7 In recent years, since traditional lab-based tests require expensive instruments and professional operations, point-ofcare testing (POCT) devices were widely developed due to their low cost, portability, simple operation and instant detection.…”

Section: Introductionmentioning

confidence: 99%

A bimetallic metal–organic framework with high enzyme-mimicking activity for an integrated electrochemical immunoassay of carcinoembryonic antigen

Liu¹,

Ye²,

Chen³

et al. 2023

Analyst

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“…For example, Wang et al Jozghorbani et al and Wang et al designed three kinds of label-free CEA immunosensors with detection limits of 0.005, 0.05, and 0.0429 ng•mL −1 , respectively [7][8][9]. Especially, a large number of reports have focused on the sandwich-type electrochemical immunosensor for CEA detection [10][11][12][13], thanks to their distinct advantages such as lower background noise, higher sensitivity, and importance, and they have higher selectivity for analytes through two specifc reactions, which are superior to label-free counterparts [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Immunosensing of Carcinoembryonic Antigen Based on Gold Nanoparticles Dotted PB@PANI Core-Shell Nanocubes as a Signal Probe

Feng

Chen

Zhang

et al. 2023

Journal of Analytical Methods in Chemistry

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Herein, a method was developed for the sensitive monitoring of carcinoembryonic antigen (CEA) by gold nanoparticles dotted prussian blue@polyaniline core-shell nanocubes (Au NPs/PB@PANI). First, a facile low-temperature method was used to prepare the uniform PB@PANI core-shell nanocubes with the assistance of PVP, where PB acted as the electron transfer mediator to provide electrochemical signals, and the PANI with excellent conductivity and desirable chemical stability not only played the role of a protective layer to prevent etching of PB in basic media but also effectively improved electron transfer. Importantly, to further enhance the electrical conductivity and biocompatibility of PB@PANI and to further enhance the electrochemical signal and capture a large amount of Ab2, Au NPs were doped on the surface of PB@PANI to form Au NPs/PB@PANI nanocomposites. Subsequently, benefiting from the advantages of core-shell structure nanoprobes and gold-platinum bimetallic nanoflower (AuPt NF), a sandwich-type electrochemical immunosensor for CEA detection was constructed, which provided a wide linear detection range from 1.0 pg·mL−1 to 100.0 ng·mL−1 and a low detection limit of 0.35 pg·mL−1 via DPV (at 3σ). Moreover, it displayed a satisfactory result when the core-shell structure nanoprobe-based immunosensor was applied to determine CEA in real human serum samples.

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Ultrasensitive Detection of Carcinoembryonic Antigen by Chitosan/Polythiophene/CdTe Electrochemical Biosensor

Cited by 12 publications

References 63 publications

Non-Enzymatic Electrochemical Sensors for Accurate and Accessible Uric Acid Detection

Non-Enzymatic Electrochemical Sensors for Accurate and Accessible Uric Acid Detection

A bimetallic metal–organic framework with high enzyme-mimicking activity for an integrated electrochemical immunoassay of carcinoembryonic antigen

Highly Sensitive Immunosensing of Carcinoembryonic Antigen Based on Gold Nanoparticles Dotted PB@PANI Core-Shell Nanocubes as a Signal Probe

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