A bimetallic metal–organic framework with high enzyme-mimicking activity for an integrated electrochemical immunoassay of carcinoembryonic antigen

Liu, Na; Ye, Mingli; Chen, Long; Qin, Xu; Shu, Yun

doi:10.1039/d3an01221b

Cited by 3 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With a wide linear range and impressive detection limits, this sensor hints at significant clinical potential, poised to revolutionize early cancer diagnosis and monitoring. 81…”

Section: Artificial Enzymes In Portable Electrochemical Sensorsmentioning

confidence: 99%

Artificial enzyme innovations in electrochemical devices: advancing wearable and portable sensing technologies

Zheng,

Cao,

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

“…With a wide linear range and impressive detection limits, this sensor hints at significant clinical potential, poised to revolutionize early cancer diagnosis and monitoring. 81…”

Section: Artificial Enzymes In Portable Electrochemical Sensorsmentioning

confidence: 99%

Artificial enzyme innovations in electrochemical devices: advancing wearable and portable sensing technologies

Zheng,

Cao,

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

“…After the formation of the antibody-AFP immunoconjugate, the catalytic ability of the MOF was greatly repressed, and the current signal was reduced, enabling sensitive detection of AFP with an LOD of 0.3 ng mL −1 . Shu et al 54 prepared an electrochemical immunosensor for the highly sensitive detection of carcinoembryonic antigen (CEA) using ammoniated Cu-Ni MOF-modified electrodes. The Cu-Ni MOF had a large specific surface area and effectively immobilized CEA antibodies.…”

Section: Electrochemical Protein Biosensorsmentioning

confidence: 99%

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

View full text Add to dashboard Cite

The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in immunology. However, the active centers of protein biomarkers are surrounded by a peptide matrix, which hinders charge transfer and results in insufficient sensor sensitivity. Therefore, electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein sensors. In this review, we summarize recent reports of electrochemical biosensors for protein biomarker detection. We highlight the latest research on electrochemical protein biosensors for the detection of cancer, viral infectious diseases, inflammation, and other diseases. The corresponding sensitive materials, transducer structures, and detection principles associated with such biosensors are also addressed generally. Finally, we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

show abstract

“…2 . 38 Primarily, a triple electrode configuration was achieved through the application of a carbon ink onto a polyethylene terephthalate (PET) platform using screen-printing techniques. An aminated Cu–Ni MOF was synthesized via a usual solvothermal approach and subsequently treated with glutaraldehyde (GA) to activate it.…”

Section: Immunosensing Approaches For Mof-derived Nanocompositesmentioning

confidence: 99%

Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors

Karimzadeh,

Mahmoudpour,

Rahimpour

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

A bimetallic metal–organic framework with high enzyme-mimicking activity for an integrated electrochemical immunoassay of carcinoembryonic antigen

Abstract: Metal-organic framework (MOF) shows excellent catalytic activity and have been widely applied in diseases and tumors diagnosis analysis. However, current assay methods usually involve cumbersome configuration and complicated procedures, which...

Cited by 3 publications

References 28 publications

Artificial enzyme innovations in electrochemical devices: advancing wearable and portable sensing technologies

Artificial enzyme innovations in electrochemical devices: advancing wearable and portable sensing technologies

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors

Contact Info

Product

Resources

About