Ultraporous ?????Tricalcium Phosphate Is Well Incorporated in Small Cavitary Defects

Anker, Christopher J.; Holdridge, Sean P; Baird, Bruce; Cohen, Hal; Damron, Timothy A.

doi:10.1097/01.blo.0000153991.94765.1b

Cited by 45 publications

(37 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It resorbs during the natural remodeling process of bone. Evidence suggests that β-TCP resorbs in the most relevant time frame in comparison to other bone substitutes such as hydroxyapatite (HA) and calcium sulfate (CaS) (Anker et al 2005 ). Vitoss has an open-interconnected structure that facilitates 3-D bone regeneration and is composed of nano-particle construction, allowing for physiologically relevant cell mediated resorption.…”

Section: Clinical Applications In Orthopaedic Surgerymentioning

confidence: 99%

Bone

Reichert¹,

Nöth²,

Berner³

et al. 2016

Regenerative Medicine - From Protocol to Patient

View full text Add to dashboard Cite

Commonly applied therapies to achieve bone reconstruction or function are restricted to the transplantation of autografts and allografts, or the implantation of metal devices or ceramic-based implants. Bone grafts generally possess osteoconductive and osteoinductive properties. They are, however, limited in access and availability, and harvest is associated with donor site morbidity, hemorrhage, risk of infection, insuffi cient transplant integration, and graft devitalisation. Research therefore focuses on alternative therapeutic concepts such as tissue engineering to aid bone regeneration. However, bench to bedside translations are infrequent as the process towards approval by regulatory bodies is protracted and costly. Approval requires both comprehensive in vitro and in vivo studies necessitating the utilization of well-standardized large preclinical animal models, fi xation devices, surgical procedures and methods of taking measurements. Only then reliable data pools can be generated which consecutively serve as a base for further research directions. The following chapter gives insight into bone morphology and physiology, and describes the clinical background necessitating research for alternative treatments. Furthermore, basic principles of bone tissue engineering are introduced as well as key points to consider when discussing preclinical animal models. Finally, successfully translated bone regeneration concepts are summarized. Keywords Bone Morphology and PhysiologyBone is a complex, constantly altering tissue and consists of cancellous and cortical bone. The specifi c architecture of bone allows the skeleton to fulfi l its mechanical functions. In adults, cortical bone accounts for 80 % of the total bone mass. It responds slowly to changes in loads and aids to protect organs, provides levers for movement, and (together with cancellous bone) stores minerals. Cancellous bone is found interiorly and comprises of a trabecular network that reduces organ weight and provides space for blood vessels and marrow. Cancellous bone has a large surface area per unit volume and a greate rate of metabolic activity. The external surface of bone is covered by periosteum (Hutmacher and Sittinger 2003 ).Specifi c collagen fi bres (Sharpey) connect periosteum and bone. These fi bres penetrate the cortex at sites exposed to high tensile forces. The periosteum comprises of an external, fi brous layer (collagenous and reticular fi bres) and an inner, proliferative layer (cambium). The cambium layer hosts osteoblasts and osteoprogenitor cells. It is capable of lamellar bone apposition and of forming primary, woven bone after a fracture. The outer fi brous layer provides elasticity and fl exibility facilitating the insertion of tendons, ligaments and muscles.Bone has a rich vascular supply receiving 10-20 % of the cardiac output. In long bones, one or two principal diaphyseal nutrient arteries represent the most important supply of arterial blood. These arteries pass obliquely through the cortical bone and divide into a...

show abstract

Section: Clinical Applications In Orthopaedic Surgerymentioning

confidence: 99%

Bone

Reichert¹,

Nöth²,

Berner³

et al. 2016

Regenerative Medicine - From Protocol to Patient

View full text Add to dashboard Cite

show abstract

“…The temporary implant materials utilized should guarantee a suitable mechanical stability and at the same time be completely degradable and should correspond to the supporting bone (cortical bone) regarding mechanical characteristics to avoid stress shielding (Daniels et al, 1990;Weiler et al, 1998Weiler et al, , 2000. Until now, temporary implants are mainly produced out of PLA (polylactic acid, D and L isomers), PGA (polyglycolic acid), TMC (trimethylene carbonate), copolymers with varying substantial ratios, PDS (polydiaxonone) as well as composite materials (calcium phosphate in combination with polymers) (Anker et al, 2005;Ignatius et al, 2001aIgnatius et al, , 2001bSakar et al, 1999;Taylor et al, 1994). The field of application of these materials is however limited due to their relatively low mechanical strength.…”

Section: State Of Science and Technologymentioning

confidence: 99%

Biocompatible Magnesium Alloys as Degradable Implant Materials - Machining Induced Surface and Subsurface Properties and Implant Performance

Denkena¹,

Lucas²,

Thorey³

et al. 2011

Special Issues on Magnesium Alloys

View full text Add to dashboard Cite

“…Several authors have reported excellent results with calcium phosphate for traumatic fractures or cavitary filling after excision of tumors or cysts. 34,35 Anker and colleagues 36 reported that tricalcium phosphate incorporated well into small cavitary defects but incorporation was incomplete after 1 year in large defects ($43 cm).…”

Section: Ceramic Bone Graft Substitutesmentioning

confidence: 99%

Perspectives on the clinical utility of allografts for bone regeneration within osseous defects: a narrative review

Miller¹,

Block²

2011

ORR

View full text Add to dashboard Cite

A variety of bone grafts and bone graft substitutes is available for treatment of osseous defects although adequate reconstruction of the residual void following fracture, arthroplasty, or tumor/cyst resection remains a therapeutic challenge. This narrative review evaluates the peer-reviewed literature and examines relevant outcomes in patients treated with bone grafts and bone graft substitutes for surgical management of osseous defects. Although autograft, xenograft, and ceramic bone graft substitutes are used for a variety of orthopedic applications, they have distinct limitations in clinical practice. Bone allograft material is a safe and effective adjunct to treatment of osseous defects.

show abstract

Ultraporous ?????Tricalcium Phosphate Is Well Incorporated in Small Cavitary Defects

Cited by 45 publications

References 16 publications

Bone

Bone

Biocompatible Magnesium Alloys as Degradable Implant Materials - Machining Induced Surface and Subsurface Properties and Implant Performance

Perspectives on the clinical utility of allografts for bone regeneration within osseous defects: a narrative review

Contact Info

Product

Resources

About