Ultraporous &b.beta;-Tricalcium Phosphate Alone or Combined with Bone Marrow Aspirate for Benign Cavitary Lesions

Abstract

While significant improvements in radiographic parameters were observed in both TCP groups over two years of follow-up, the addition of BM was not found to provide any significant benefit. Results should not be extrapolated to other bone graft substitutes used for this purpose.

The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

“…Even though osteogenic cells are important for bone regeneration, some studies have shown that ceramic bone substitutes alone or calcium phosphate cement application can heal adequately without the need of bone marrow aspirate to treat benign bone cavity or tibial plateau fractures [20,21]. Thus the kind of biomaterial and the progenitor cells to be used may probably be dependent on the type and location of the bone defect.…”

Biologic adjuvants and bone: current use in orthopedic surgery

“…Age and sex also play a role, as there were fewer colony forming units (CFUs) found as age increases [26]. In a separate study, BMAC was used in conjunction with TCP to fill benign cavitary lesions, and there was no reported benefit [27]. Overall, BMAC is an osteoinductive product that often must be combined with an osteoconductive material to produce effective bone formation.…”

Rekonstruktion von Segmentdefekten der langen Röhrenknochen

“…Neben autologem Knochenmarkaspirat, Spongiosaplastik und Knochentransplantat stehen u. a. auch demineralisierte Knochenmatrix, alloplastische und xenogene Materialien, Biogläser, Keramiken und resorbierbare/ nichtresorbierbare Polymere sowie verschiedene Kombinationen der einzelnen Materialien zur Verfügung. Der "ideale" Knochenersatzstoff ist bisher jedoch nicht verfügbar [21,22].…”

“…Jedoch liegen reproduzierbare Ergebnisse bei der Behandlung großer Knochendefekte nicht vor. Neben der Tatsache, dass bei den Knochenersatzstoffen avitale Substanzen verwendet werden, existieren keine verwertbaren Produkte, die eine segmentale Überbrückung im Sinne eines vitalen Röhrenknochens erwarten lassen [22,27,48]. The supplement containing this article is not sponsored by industry.…”