Ultralong recovery time in nanosecond electroporation systems enabled by orientational-disordering processes

Abstract

A few-volt nanosecond alternating-current stimulation method with an increased number of pulses exploiting orientational-disordering processes.

Ultrasensitive low-probe-concentration PANC-1 and MCF-7 cancer cell sensors enabled by combined 2D-material-polymer-phage frameworks

“…Recently, characterizing electrical signatures of cancer cell populations has generated substantial interest in the scientific community. [11][12][13][14][15][16] The unique biophysical properties of each cancer cell type provide essential knowledge that could aid in the diagnosis of diseases, clinical trial designs and drug development. 14 The electrical responses of cancer cell populations are of particular interest, because cancer cells exhibit a collective behavior in terms of cell migration and invasion.…”

“…[11][12][13][14][15][16] The unique biophysical properties of each cancer cell type provide essential knowledge that could aid in the diagnosis of diseases, clinical trial designs and drug development. 14 The electrical responses of cancer cell populations are of particular interest, because cancer cells exhibit a collective behavior in terms of cell migration and invasion. [17][18][19] However, sensing medium cell populations is extremely challenging because traditional analytical methodologies can be labor-intensive and the compositions of cell monolayers tend to be different.…”

Janus polymer-grafted nanoparticles mimicking membrane repair proteins for the prevention of lipid membrane rupture

“…The integrity of the plasma membrane (PM) is critical for cell survival and normal cellular function. [1][2][3][4] However, disruption of the cell membrane often occurs due to numerous threats, such as mechanical stress and biochemical agents (e.g., poreforming toxins), [5][6][7][8][9] which increases the risk of cell lysis and necrosis, especially at a high degree of damage. Normally, cells are able to deal effectively with limited PM damage, owing to the function of membrane repair proteins.…”

Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS2-powered MCF-7 cancer cell sensors

“…The digital biomolecular sensor (DBS) technology has demonstrated to be favourable in examining cell-based interactions by analysing the current variation in a cancer cell element as a result of various advantages, such as rapid specific detection, low cost and high sensitivity. [22][23][24][25][26] However, due to the restricted number of cells in the cancer cell element, utilizing the conventional DBS scheme to detect cancer cells at low cell populations remains difficult. Thus, there is an urgent need to develop emerging material systems with high conductivity to enhance DBS performance.…”