Ultrahigh sensitive graphene oxide/conducting polymer composite based biosensor for cholesterol and bilirubin detection

Kumar, Anup; Gupta, Gourang Hari; Singh, Gajendar; More, Namdev; Keerthana, M; Sharma, Ashish; Jawade, Dhanajay; Balu, Aishwarya; Kapusetti, Govinda

doi:10.1016/j.biosx.2022.100290

Cited by 11 publications

(6 citation statements)

References 36 publications

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“…In contrast, the SnO 2 -PANI/NF sensor was fabricated without the use of any sophisticated techniques and displays a favorable low limit of detection along with a wide linear range (1-100 μM). The sensitivity of the SnO 2 -PANI/NF sensor surpasses the sensitivity of most previously reported sensors [19,42]. The nickel foam electrode used in this work features a threedimensional, porous structure that provides a wide surface area for CH detection.…”

Section: / /mentioning

confidence: 80%

Tin oxide-polyaniline nanocomposite modified nickel foam for highly selective and sensitive detection of cholesterol in simulated blood serum samples

Singh¹,

Sreekumar²,

Badhulika³

2023

Nanotechnology

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Cholesterol (CH) is a vital diagnostic marker for a variety of diseases, making its detection crucial in biological applications including clinical practice. In this work, we report the synthesis of tin oxide-polyaniline nanocomposite-modified nickel foam (SnO2-PANI/NF) for non-enzymatic detection of CH in simulated human blood serum. SnO2 was synthesized via the hydrothermal method, followed by the synthesis of SnO2-PANI nanocomposite through in situ chemical polymerization of aniline using ammonium persulfate as the oxidizing agent. Morphological studies display agglomerated SnO2-PANI, which possess diameters ranging from an average particle size of ∼50 to ∼500 nm, and the XRD analysis revealed the tetragonal structure of the SnO2-PANI nanocomposite. Optimization studies demonstrating the effect of pH and weight percentage are performed to improve the electrocatalytic performance of the sensor. The non-enzymatic SnO2-PANI/NF sensor exhibits a linear range of 1–100 μM with a sensitivity of 300 μA μM−1/cm−2 towards CH sensing and a low limit of detection of 0.25 μM (=3 S m−1). SnO2-PANI/NF facilitates the electrooxidation of CH to form cholestenone by accepting electrons generated during the reaction and transferring them to the nickel foam electrode via Fe (III)/Fe (IV) conversion, resulting in an increased electrochemical current response. The SnO2-PANI/NF sensor demonstrated excellent selectivity against interfering species such as Na+, Cl−, K+, glucose, ascorbic acid, and SO4 2−. The sensor successfully determined the concentration of CH in simulated blood serum samples, demonstrating SnO2-PANI as a potential platform for a variety of electrochemical-based bioanalytical applications.

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Section: / /mentioning

confidence: 80%

Tin oxide-polyaniline nanocomposite modified nickel foam for highly selective and sensitive detection of cholesterol in simulated blood serum samples

Singh¹,

Sreekumar²,

Badhulika³

2023

Nanotechnology

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“…Moreover, due to its nonspecific nature, this sensor fabrication method could possibly be employed for other diseases. Aside from these, PPy has also been used in the fabrication of sensors for bioanalytes such as cholesterol, 63 bilirubin, 64 and glucose, 65 among others. These studies show the possibility of using PPy in the facile and low-cost fabrication of point-of-care (POC) and/or wearable devices for various diseases without compromising detection capabilities, as exhibited by the sensor performances compared to standard ELISA techniques.…”

Section: Conducting Polymersmentioning

confidence: 99%

Recent Progress in Biomedical Sensors Based on Conducting Polymer Hydrogels

Gamboa

Paulo-Mirasol

Estrany

et al. 2023

ACS Appl. Bio Mater.

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Biosensors are increasingly taking a more active role in health science. The current needs for the constant monitoring of biomedical signals, as well as the growing spending on public health, make it necessary to search for materials with a combination of properties such as biocompatibility, electroactivity, resorption, and high selectivity to certain bioanalytes. Conducting polymer hydrogels seem to be a very promising materials, since they present many of the necessary properties to be used as biosensors. Furthermore, their properties can be shaped and enhanced by designing conductive polymer hydrogel-based composites with more specific functionalities depending on the end application. This work will review the recent state of the art of different biological hydrogels for biosensor applications, discuss the properties of the different components alone and in combination, and reveal their high potential as candidate materials in the fabrication of all-organic diagnostic, wearable, and implantable sensor devices.

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“…The application of an additional Nafion cation-exchange film over the enzyme in the polymer matrix reduces the permeability of the film to the penetration of urates and other compounds. For example, the protective effect of a Nafion film for biosensors based on cholesterol oxidase and bilirubin oxidase immobilized on the conducting polymers PPy and PANI [ 103 ] and acetylcholinesterase on microporous organic polymers was shown [ 104 ].…”

Section: Biosensors Based On Conductive Polymersmentioning

confidence: 99%

Conductive Polymers and Their Nanocomposites: Application Features in Biosensors and Biofuel Cells

Kuznetsova,

Arlyapov,

Plekhanova

et al. 2023

Polymers

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Conductive polymers and their composites are excellent materials for coupling biological materials and electrodes in bioelectrochemical systems. It is assumed that their relevance and introduction to the field of bioelectrochemical devices will only grow due to their tunable conductivity, easy modification, and biocompatibility. This review analyzes the main trends and trends in the development of the methodology for the application of conductive polymers and their use in biosensors and biofuel elements, as well as describes their future prospects. Approaches to the synthesis of such materials and the peculiarities of obtaining their nanocomposites are presented. Special emphasis is placed on the features of the interfaces of such materials with biological objects.

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Ultrahigh sensitive graphene oxide/conducting polymer composite based biosensor for cholesterol and bilirubin detection

Cited by 11 publications

References 36 publications

Tin oxide-polyaniline nanocomposite modified nickel foam for highly selective and sensitive detection of cholesterol in simulated blood serum samples

Tin oxide-polyaniline nanocomposite modified nickel foam for highly selective and sensitive detection of cholesterol in simulated blood serum samples

Recent Progress in Biomedical Sensors Based on Conducting Polymer Hydrogels

Conductive Polymers and Their Nanocomposites: Application Features in Biosensors and Biofuel Cells

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