Ultrafine yttria nanoparticles: synthesis and characterization

Kassem, Samr; Mohamed, Midhat N.; Ahmed, Mohamed; El-Dek, S.I.

doi:10.1080/22243682.2015.1078742

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Ultrafine YNPs were synthesized as previously described (Kassem et al 2015). After that, surface functionalization was performed by silanizing YNPs with 3-trimethoxysilylpropyl methacrylate and grafting an ethylene glycol methacrylate phosphate (EGMP) co-polymer, as described in Sayour et al (2019) in addition to N-Fluorescein Acrylamide which was added in polymerization mixture as fluorescent monomer (Tan et al 1992).…”

Section: Synthesis Of Functionalized Core-shell Yttrium Oxide Nanopar...mentioning

confidence: 99%

“…In previous work, ultrafine YNPs were prepared and the surface modification was achieved by grafting a copolymer made of poly EGMP to improve the biocompatibility and enhance biodistribution of YNPs with dose up to 0.1 mg/g bwt in normal 1-month-old Sprague-Dawley rats and pointed to the ability of NPs to distribute successfully to the brain shortly after tail vein injection without toxicity. Also, we approved that functionalized core-shell YNPs possess powerful antioxidant activity after one dose injection of 0.2 mg in a heat-stressed rat model but further research is needed to give answers on the dose-dependent antioxidant efficacy of YNPs with rescuing the oxidative stress-induced degenerative disorders in different organs especially the brain (Kassem et al 2015(Kassem et al , 2020Sayour et al 2019).…”

Section: Introductionmentioning

confidence: 99%

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In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

Kassem

Arafa²,

Yehya

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Herein, we assess the dose-dependent antioxidant efficacy of ultrafine spherical functionalized core–shell yttrium oxide nanoparticles (YNPs) with a mean size of 7–8 nm and modified with poly EGMP (ethylene glycol methacrylate phosphate) and N-Fluorescein Acrylamide. The antioxidant properties of these nanoparticles were investigated in three groups of Sprague–Dawley rats (10 per group) exposed to environmental stress daily for 1 week and one control group. Groups 2 and 3 were intravenously injected twice a week with YNPs at 0.3 and 0.5 mg at 2nd and 5th day of environmental stress exposure respectively. Different samples of blood and serum were collected from all experimental groups at end of the experiment to measure oxidative biomarkers such as total antioxidant capacity (TAC), hydroxyl radical antioxidant capacity (HORAC), oxygen radical antioxidant capacity (ORAC), malondialdehyde (MDA), and oxidants concentration as hydrogen peroxide (H2O2). The liver, brain, and spleen tissues were collected for fluorescence imaging and histopathological examination in addition to brain tissue examination by transmission electron microscope (TEM). Inductively coupled plasma-mass spectrometry (ICP-MS) was used to estimate YNPs translocation and concentration in tissues which is consecutively dependent on the dose of administration. Depending on all results, poly EGMP YNPs (poly EGMP yttrium oxide nanoparticles) can act as a potent direct antioxidant in a dose-dependent manner with good permeability through blood–brain barrier (BBB). Also, the neuroprotective effect of YNPs opening the door to a new therapeutic approach for modulating oxidative stress–related neural disorders. Highlights • The dose-dependent antioxidant efficacy of ultrafine spherical functionalized core–shell yttrium oxide nanoparticles (YNPs) with a mean size of 7–8 nm and modified with poly EGMP (ethylene glycol methacrylate phosphate) and N-Fluorescein Acrylamide was assessed. • The dose of administration directly affecting the brain, liver, and spleen tissues distribution, retention, and uptake of YNPs and direct correlation between the absorbed amount and higher dose administered. • YNPs can act as a potent direct antioxidant in a dose-dependent manner with good permeability through blood–brain barrier (BBB). Graphical abstract

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Section: Synthesis Of Functionalized Core-shell Yttrium Oxide Nanopar...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

Kassem

Arafa²,

Yehya

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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“…In this study, yttrium oxide nanoparticles were used to improve or alleviate cognitive impairments caused by cholestasis. The results showed that intraperitoneal injection of yttrium oxide nanoparticles from one day after surgery for 21 days increased the ability to acquire and recall memory and increased the expression of genes involved in mitochondrial biogenesis in cholestatic rats (Buzea et al, 2007, Kassem et al, 2015. Yttrium oxide nanoparticles can cross the blood-brain barrier and protect cells against free radicals and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…These particles have wide diagnostic and therapeutic applications. Several studies have shown that nanoparticles, due to their antioxidant properties, can protect cells against oxidative stress, the production of free radicals, and neural damage (Buzea et al, 2007;Kassem et al, 2015). Nanoparticles also increase the synaptic exibility of brain hippocampal neurons, and by blocking NMDA-dependent pathways, they increase magnesium concentrations in the brain cell spaces, thereby improving memory.…”

Section: Introductionmentioning

confidence: 99%

The effect of yttrium oxide nanoparticles on memory, inflammatory responses and mitochondrial biogenesis in cholestatic male Wistar rats

Khaledi,

Amiri,

Esfahani

et al. 2024

Preprint

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Background and Objectives: Cholestasis can lead to oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and ultimately causes cognitive damage, such as memory malfunctions. Considering their anti-inflammatory and protective effects, nanoparticles may be effective for the treatment of neurological disorders or for transferring medications through the blood-brain barrier. This study investigated the protective effect of yttrium oxide nanoparticles (Y2O3NPs) on cognitive disorders, inflammatory response and mitochondrial biogenesis caused by cholestasis in rat hippocampus. Methods: Male Wistar rats were randomly divided into seven groups: control, sham, vehicle, cholestasis, and three groups of cholestatic rats, which received doses of 0.1, 0.3, and 0.5 mg/kg Y2O3NPs, respectively for 21 days. The Morris water maze, passive avoidance, and elevated plus maze tests were used to assess the learning and memory of the rats. The expression of genes involved in mitochondrial biogenesis (PGC-1α, NRF-1, and TFAM) and pro-inflammatory genes (TNF-α, IL-6, and IL-1β) were evaluated by real-time PCR technique. Results: Cholestasis led to learning and memory dysfunctions, decreased the expression of genes involved in mitochondrial biogenesis, and increased the expression of genes involved in neuroinflammation. Intraperitoneal injection (IP) of Y2O3NPs, especially at a dose of 0.5 mg/kg, enhanced the recognition and recall memory, increased the expression of factors involved in mitochondrial biogenesis (PGC-1α, NRF-1, and TFAM), and decreased neuroinflammation (TNF-α, IL-6, and IL-1β). Conclusion: This study demonstrated that Y2O3NPs reduced memory disorders caused by cholestasis. This nanoparticle increased the expression of factors involved in mitochondrial biogenesis, reduced the inflammatory responses in the hippocampus of cholestasis animals, and possibly alleviated cognitive disorders through this mechanism.

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Biocompatibility and biodistribution of surface-modified yttrium oxide nanoparticles for potential theranostic applications

Sayour¹,

Kassem²,

Canfarotta

et al. 2019

Environ Sci Pollut Res

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Ultrafine yttria nanoparticles: synthesis and characterization

Cited by 5 publications

References 10 publications

In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

The effect of yttrium oxide nanoparticles on memory, inflammatory responses and mitochondrial biogenesis in cholestatic male Wistar rats

Biocompatibility and biodistribution of surface-modified yttrium oxide nanoparticles for potential theranostic applications

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