Biocompatibility and biodistribution of surface-modified yttrium oxide nanoparticles for potential theranostic applications

Sayour, Hossam E. M.; Kassem, Samr; Canfarotta, Francesco; Czulak, J.; Mohamed, Mohamed R.; Piletsky, Sergey A.

doi:10.1007/s11356-019-04309-9

Cited by 13 publications

(6 citation statements)

References 47 publications

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“…In previous work, ultrafine YNPs were prepared and the surface modification was achieved by grafting a copolymer made of poly EGMP to improve the biocompatibility and enhance biodistribution of YNPs with dose up to 0.1 mg/g bwt in normal 1-month-old Sprague-Dawley rats and pointed to the ability of NPs to distribute successfully to the brain shortly after tail vein injection without toxicity. Also, we approved that functionalized core-shell YNPs possess powerful antioxidant activity after one dose injection of 0.2 mg in a heat-stressed rat model but further research is needed to give answers on the dose-dependent antioxidant efficacy of YNPs with rescuing the oxidative stress-induced degenerative disorders in different organs especially the brain (Kassem et al 2015(Kassem et al , 2020Sayour et al 2019).…”

Section: Introductionmentioning

confidence: 99%

In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

Kassem

Arafa²,

Yehya

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Herein, we assess the dose-dependent antioxidant efficacy of ultrafine spherical functionalized core–shell yttrium oxide nanoparticles (YNPs) with a mean size of 7–8 nm and modified with poly EGMP (ethylene glycol methacrylate phosphate) and N-Fluorescein Acrylamide. The antioxidant properties of these nanoparticles were investigated in three groups of Sprague–Dawley rats (10 per group) exposed to environmental stress daily for 1 week and one control group. Groups 2 and 3 were intravenously injected twice a week with YNPs at 0.3 and 0.5 mg at 2nd and 5th day of environmental stress exposure respectively. Different samples of blood and serum were collected from all experimental groups at end of the experiment to measure oxidative biomarkers such as total antioxidant capacity (TAC), hydroxyl radical antioxidant capacity (HORAC), oxygen radical antioxidant capacity (ORAC), malondialdehyde (MDA), and oxidants concentration as hydrogen peroxide (H2O2). The liver, brain, and spleen tissues were collected for fluorescence imaging and histopathological examination in addition to brain tissue examination by transmission electron microscope (TEM). Inductively coupled plasma-mass spectrometry (ICP-MS) was used to estimate YNPs translocation and concentration in tissues which is consecutively dependent on the dose of administration. Depending on all results, poly EGMP YNPs (poly EGMP yttrium oxide nanoparticles) can act as a potent direct antioxidant in a dose-dependent manner with good permeability through blood–brain barrier (BBB). Also, the neuroprotective effect of YNPs opening the door to a new therapeutic approach for modulating oxidative stress–related neural disorders. Highlights • The dose-dependent antioxidant efficacy of ultrafine spherical functionalized core–shell yttrium oxide nanoparticles (YNPs) with a mean size of 7–8 nm and modified with poly EGMP (ethylene glycol methacrylate phosphate) and N-Fluorescein Acrylamide was assessed. • The dose of administration directly affecting the brain, liver, and spleen tissues distribution, retention, and uptake of YNPs and direct correlation between the absorbed amount and higher dose administered. • YNPs can act as a potent direct antioxidant in a dose-dependent manner with good permeability through blood–brain barrier (BBB). Graphical abstract

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Section: Introductionmentioning

confidence: 99%

In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

Kassem

Arafa²,

Yehya

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Other researchers have examined NPs of Y 2 O 3 and yttrium ions simultaneously in yeast and have concluded the yttrium ions derived from NPs responsible for the toxicity observed in yeast cells [36]. In mouse normal hepatocyte cell line, Y 2 O 3 NPs (7-8 nm) coated with polymer of acrylic acid have been reported to cause toxicity at the concentration of 10 µg/mL [21]. On the other hand, NPs of Y 2 O 3 have been reported to be antioxidant and protective in cells of neural [18,19] and retinal [20] origin.…”

Section: Discussionmentioning

confidence: 99%

“…This study, therefore, reports a comparative finding in terms of surface reactivity and biocompatibility of Y 2 O 3 NPs with the chemically related NPs of CeO 2 and chemically un-related NPs of ZnO. It is notable that NPs of Y 2 O 3 , like that of CeO 2 NPs, have been reported to be antioxidant and protective in cells of neural [18,19] and retinal [20], whereas some investigators have reported this NP as oxidative and toxic [21,22]. In this study, we have provided a comparative data on surface reactivity with BSA and media components which is not known.…”

Section: Introductionmentioning

confidence: 87%

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High Surface Reactivity and Biocompatibility of Y2O3 NPs in Human MCF-7 Epithelial and HT-1080 Fibro-Blast Cells

et al. 2020

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This study aimed to generate a comparative data on biological response of yttrium oxide nanoparticles (Y2O3 NPs) with the antioxidant CeO2 NPs and pro-oxidant ZnO NPs. Sizes of Y2O3 NPs were found to be in the range of 35±10 nm as measured by TEM and were larger from its hydrodynamic sizes in water (1004 ± 134 nm), PBS (3373 ± 249 nm), serum free culture media (1735 ± 305 nm) and complete culture media (542 ± 108 nm). Surface reactivity of Y2O3 NPs with bovine serum albumin (BSA) was found significantly higher than for CeO2 and ZnO NPs. The displacement studies clearly suggested that adsorption to either BSA, filtered serum or serum free media was quite stable, and was dependent on whichever component interacted first with the Y2O3 NPs. Enzyme mimetic activity, like that of CeO2 NPs, was not detected for the NPs of Y2O3 or ZnO. Cell viability measured by MTT and neutral red uptake (NRU) assays suggested Y2O3 NPs were not toxic in human breast carcinoma MCF-7 and fibroblast HT-1080 cells up to the concentration of 200 μg/mL for a 24 h treatment period. Oxidative stress markers suggested Y2O3 NPs to be tolerably non-oxidative and biocompatible. Moreover, mitochondrial potential determined by JC-1 as well as lysosomal activity determined by lysotracker (LTR) remained un-affected and intact due to Y2O3 and CeO2 NPs whereas, as expected, were significantly induced by ZnO NPs. Hoechst-PI dual staining clearly suggested apoptotic potential of only ZnO NPs. With high surface reactivity and biocompatibility, NPs of Y2O3 could be a promising agent in the field of nanomedicine.

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“…& A different review article bySayour et al enumer- ated the multiple advantages of surface-modified yttrium oxide NPs, including enhanced colloidal stability, free radical scavenging activity, and low risk of cytotoxicity. These advantages could pave the way towards their use as theranostics in neurodegenerative diseases(Sayour et al 2019).…”

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confidence: 99%

Advances in nanotechnology, nanopollution, nanotoxicology, and nanomedicine

Aleya

Abdel-Daim

2020

Environ Sci Pollut Res

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Nanotechnology is a science that deals with the design, characterization, synthesis, and application of nanoscale materials (1-100 nm). Nanomaterials (NMs) have unique physicochemical characteristics, including ultra-small size, large surface area to mass ratio, and high reactivity. Nanomedicine is the application of nanotechnology in medicine to advance diagnostic, preventive, and therapeutic strategies. The potent antioxidant properties of some NMs open the door to develop new therapies with enhanced, targeted actions. However, oxidative stress is the main adverse effect of metallic oxide NMs, such as nickel oxide, zinc oxide, and titanium dioxide. Therefore, NMs have double-edged effects on cellular redox hemostasis. Recently, many researchers have focused on the ecological and safety issues of synthetic NMs to reduce the risk of their toxicity. The present special issue "Advances in Nanotechnology, Nanopollution, Nanotoxicology and Nanomedicine (ANNNN)" is dedicated to integrate the previous and the current biological, medical, and ecological data on NMs.

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Biocompatibility and biodistribution of surface-modified yttrium oxide nanoparticles for potential theranostic applications

Cited by 13 publications

References 47 publications

In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

In vivo study of dose-dependent antioxidant efficacy of functionalized core–shell yttrium oxide nanoparticles

High Surface Reactivity and Biocompatibility of Y2O3 NPs in Human MCF-7 Epithelial and HT-1080 Fibro-Blast Cells

Advances in nanotechnology, nanopollution, nanotoxicology, and nanomedicine

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