Ultrafine Graphene Nanomesh with Large On/Off Ratio for High‐Performance Flexible Biosensors

Abstract

Graphene is an attractive material for flexible electronics and biosensors, yet its zero bandgap nature has limited the on/off ratio of field-effect transistors (FETs) and the sensitivity of biosensors based on graphene. Graphene nanomesh (GNM), a continuous 2D graphene nanostructure with a high density of holes punched in the basal plane, has been created to introduce lateral confinement and enable improved on/off ratio. However, the GNMs produced to date typically have a relatively large dimension (constriction neck width >5 nm) and low on/off ratio (≈100) limited by the resolution of the lithography process used. Here, the exploration of a directly grown mesoporous silica template is reported for the preparation of ultrafine GNMs with considerably narrower neck width (<3 nm) and strong quantum confinement to enable flexible FETs with greatly improved on/off ratio (up to 1000). With excellent electronic properties and high surface area for the functionalization of specific receptors, it is further shown that the GNM FETs can be readily used to construct highly sensitive biosensors for selective detection of human epidermal growth factor receptor 2, which is further demonstrated for real-time detection of breast cancer cells overexpressed with receptor 2 down to single-cell level. The studies provide a simple and scalable method to GNMs with potential applications for flexible nanoelectronics and biosensors.

Graphene-based two-dimensional Janus materials

“…In another work reported by Yang et al, 131 one side of a graphene nanomesh was immobilized with pyrene modified, a HER2-specific aptamer, via the π-π interaction between pyrene and graphene's basal plane, as shown in Fig. 8.…”

A low-dimension structure strategy for flexible photodetectors based on perovskite nanosheets/ZnO nanowires with broadband photoresponse

“…Flexible electronic devices with highly integrated, compact, and portable features are very attractive in the fields of smart photodetectors (PDs) [1][2][3][4][5][6][7], wearable sensors [8][9][10][11], bendable solar cells [12][13][14][15], and field-emission transistors [16][17][18][19]. Among various flexible devices, PDs have aroused extensive attention due to their wide ap-plications in flame detection, optical communication, and environmental monitoring [20][21][22][23][24][25].…”

Influence of Bioreceptor Layer Structure on Myelin Basic Protein Detection using Organic Field Effect Transistor‐Based Biosensors

“…Organic field‐effect transistor (OFET)‐based sensors are currently considered for various applications such as gas sensing, biosensing, and pressure sensing . OFET‐based biosensors are being widely studied for potentially fast clinical diagnostics, with the advantages of flexibility, sensitivity, and low cost . Particularly, OFET‐based biosensors for protein sensing have progressed remarkably for label‐free analyte detection based on the specific immune binding property innate to particular antibodies .…”