Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis

Abstract

Traditional nuclear magnetic resonance (NMR) spectroscopy relies on the versatile chemical information conveyed by spectra. To complement conventional NMR, Laplace NMR explores diffusion and relaxation phenomena to reveal details on molecular motions. Under a broad concept of ultrafast multidimensional Laplace NMR, here we introduce an ultrafast diffusion-relaxation correlation experiment enhancing the resolution and information content of corresponding 1D experiments as well as reducing the experiment time by one to two orders of magnitude or more as compared with its conventional 2D counterpart. We demonstrate that the method allows one to distinguish identical molecules in different physical environments and provides chemical resolution missing in NMR spectra. Although the sensitivity of the new method is reduced due to spatial encoding, the single-scan approach enables one to use hyperpolarized substances to boost the sensitivity by several orders of magnitude, significantly enhancing the overall sensitivity of multidimensional Laplace NMR.

NMR Hyperpolarization Techniques of Gases

“…In addition, the progress achieved in the field of single-scan ultra-fast NMR techniques [235] also offers new capabilities, which earlier were considered incompatible with NMR hyperpolarization. For example, recent work demonstrates the feasibility of single-scan 2D Laplace NMR experiments of dissolved HP propene, [236] and the method should be applicable, e.g. , for the investigation of dynamics and physical environments of HP gases in porous media, both with high-field and low-field (mobile) NMR instruments.…”

Sensitivity and resolution of two-dimensional NMR diffusion-relaxation measurements

“…successfully applied to fluid mixtures with multiple aqueous, hydrocarbon and lipid phases and inside porous media [2,3,4,5,6,7,8,9,10]. Using instruments with inside-out geometries that are lowered into boreholes, it is possible to apply this technique to characterize the fluids in earth formations, many kilometers underground [11,12].…”

NMR Hyperpolarization Techniques of Gases

“…In addition, the progress achieved in the field of singlescan ultra-fast NMR techniques [234] also offers new capabilities, which earlier were considered incompatible with NMR hyperpolarization. For example, recent work demonstrates the feasibility of single-scan 2D Laplace NMR experiments of dissolved HP propene, [235] and the method should be applicable, e.g., for the investigation of dynamics and physical environments of HP gases in porous media, both with high-field and low-field (mobile) NMR instruments. [235][236] …”

“…For example, recent work demonstrates the feasibility of single-scan 2D Laplace NMR experiments of dissolved HP propene, [235] and the method should be applicable, e.g., for the investigation of dynamics and physical environments of HP gases in porous media, both with high-field and low-field (mobile) NMR instruments. [235][236] …”