Ultrafast Dynamic Contrast-Enhanced Breast MRI: Lesion Conspicuity and Size Assessment according to Background Parenchymal Enhancement

Kim, Soo Yeon; Cho, Nariya; Choi, Yunhee; Shin, Sung Ui; Kim, Eun Sil; Lee, Sang Ho; Chang, Jung Min; Moon, Woo Kyung

doi:10.3348/kjr.2019.0567

Cited by 23 publications

(18 citation statements)

References 33 publications

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“…Honda et al found that BPE was lower on the twelfth and twentieth phases of a 75 s ultrafast protocol compared to the first post-contrast phase of conventional dynamic contrast-enhanced MRI, with higher lesion detectability at the ultrafast protocol time points in patients with higher BPE at the conventional MRI time point [36]. Other studies have also demonstrated higher lesion conspicuity in cases with moderate or marked BPE [37,38].…”

Section: Bpe On Emerging Mri Protocolsmentioning

confidence: 98%

Background Parenchymal Enhancement on Breast MRI: Assessment and Clinical Implications

2021

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Purpose of Review To present recent literature regarding the assessment and clinical implications of background parenchymal enhancement on breast MRI. Recent Findings The qualitative assessment of BPE remains variable within the literature, as well as in clinical practice. Several different quantitative approaches have been investigated in recent years, most commonly region of interest-based and segmentation-based assessments. However, quantitative assessment has not become standard in clinical practice to date. Numerous studies have demonstrated a clear association between higher BPE and future breast cancer risk. While higher BPE does not appear to significantly impact cancer detection, it may result in a higher abnormal interpretation rate. BPE is also likely a marker of pathologic complete response after neoadjuvant chemotherapy, with decreases in BPE during and after neoadjuvant chemotherapy correlated with pCR. In contrast, pre-treatment BPE does not appear to be predictive of pCR. The association between BPE and prognosis is less clear, with heterogeneous results in the literature. Summary Assessment of BPE continues to evolve, with heterogeneity in approaches to both qualitative and quantitative assessment. The level of BPE has important clinical implications, with associations with future breast cancer risk and treatment response. BPE may also be an imaging marker of prognosis, but future research is needed on this topic.

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Section: Bpe On Emerging Mri Protocolsmentioning

confidence: 98%

Background Parenchymal Enhancement on Breast MRI: Assessment and Clinical Implications

2021

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“…Ultrafast MRI is a contrast material-based technique that leverages radiology.rsna.org n Radiology: Volume 000: Number 0-Month 2021 a high-temporal-resolution sequence (,10 seconds) performed within the first 1-2 minutes after contrast material administration. Qualitatively, ultrafast techniques may help visualize important nonmass enhancement that differentiates DCIS from benign background parenchymal enhancement (70). Some quantitative metrics, including time to enhancement and maximum slope, have promise for improving MRI specificity (71,72).…”

Section: Mri Examinationmentioning

confidence: 99%

Ductal Carcinoma in Situ: State-of-the-Art Review

et al. 2022

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“…Another study also concluded that UF-DCE MRI could improve lesion conspicuity compared to conventional DCE-MRI, especially in women with premenopausal status and moderate-to-marked BPE. 8 In practice, reviewing maximum intensity projection (MIP) images of several time frames from UF-DCE MRI is a quick way of finding the target lesions ( Fig. 4 ).…”

Section: How To Interpret Uf-dce Mrimentioning

confidence: 99%

“…For example, UF-DCE MRI is useful in identifying hypervascular lesions when the background parenchymal enhancement (BPE) is marked, often observed in young women. 7 , 8 On the other hand, there may be differences caused by the variation in image acquisition protocols. In order to clarify the value of UF-DCE MRI in the care of breast cancer patients, these variables should be clarified.…”

Section: Introductionmentioning

confidence: 99%

Ultrafast Dynamic Contrast-enhanced MRI of the Breast: How Is It Used?

Kataoka

Honda

Ohashi

et al. 2022

MRMS

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Ultrafast dynamic contrast-enhanced (UF-DCE) MRI is a new approach to capture kinetic information in the very early post-contrast period with high temporal resolution while keeping reasonable spatial resolution. The detailed timing and shape of the upslope in the time–intensity curve are analyzed. New kinetic parameters obtained from UF-DCE MRI are useful in differentiating malignant from benign lesions and in evaluating prognostic markers of the breast cancers. Clinically, UF-DCE MRI contributes in identifying hypervascular lesions when the background parenchymal enhancement (BPE) is marked on conventional dynamic MRI. This review starts with the technical aspect of accelerated acquisition. Practical aspects of UF-DCE MRI include identification of target hypervascular lesions from marked BPE and diagnosis of malignant and benign lesions based on new kinetic parameters derived from UF-DCE MRI: maximum slope (MS), time to enhance (TTE), bolus arrival time (BAT), time interval between arterial and venous visualization (AVI), and empirical mathematical model (EMM). The parameters derived from UF-DCE MRI are compared in terms of their diagnostic performance and association with prognostic markers. Pitfalls of UF-DCE MRI in the clinical situation are also covered. Since UF-DCE MRI is an evolving technique, future prospects of UF-DCE MRI are discussed in detail by citing recent evidence. The topic covers prediction of treatment response, multiparametric approach using DWI-derived parameters, evaluation of tumor-related vessels, and application of artificial intelligence for UF-DCE MRI. Along with comprehensive literature review, illustrative clinical cases are used to understand the value of UF-DCE MRI.

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Ultrafast Dynamic Contrast-Enhanced Breast MRI: Lesion Conspicuity and Size Assessment according to Background Parenchymal Enhancement

Abstract: Breast ultrafast dynamic contrast-enhanced (DCE)-MRI takes multiple images before the first post-contrast phase of conventional DCE-MRI (1-13). High spatiotemporal resolution can be achieved with the use of various

Cited by 23 publications

References 33 publications

Background Parenchymal Enhancement on Breast MRI: Assessment and Clinical Implications

Background Parenchymal Enhancement on Breast MRI: Assessment and Clinical Implications

Ductal Carcinoma in Situ: State-of-the-Art Review

Ultrafast Dynamic Contrast-enhanced MRI of the Breast: How Is It Used?

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