Ultraductile, notch and stab resistant supramolecular hydrogels via host–guest interactions

Tan, Mei; Cui, Yulin; Zhu, Aidi; Han, Han; Guo, Mingyu; Jiang, Ming

doi:10.1039/c5py01073j

Cited by 24 publications

(10 citation statements)

References 33 publications

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“…Multivalent noncovalent interactions have been commonly found in many biological structures and inspired scientists to develop advanced supramolecular hydrogels. − Herein, to address the above-mentioned challenge, we report the facile preparation and excellent fatigue resistance of highly swollen hydrogels cross-linked by multivalent β-cyclodextrin/adamantane (βCD/AD) host–guest interactions. Under physiological conditions, the highly swollen hydrogels can withstand up to 90% compressive strains and rapidly recover spontaneously because of the fast binding kinetics of the host–guest complexes, , giving rise to the excellent deformability and superior fatigue resistance.…”

Section: Introductionmentioning

confidence: 99%

Multivalent Host–Guest Hydrogels as Fatigue-Resistant 3D Matrix for Excessive Mechanical Stimulation of Encapsulated Cells

Wei¹,

Chen²,

Li³

et al. 2017

Chem. Mater.

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Fatigue resistance of hydrogels is critical to their applications in load-bearing sites of soft tissues that are usually subjected to continuous loadings, such as joint cartilage. However, hydrogels usually swell under physiological conditions and exhibit inevitable fatigue during excessive mechanical loadings. Here we show that hydrogels cross-linked by multivalent host–guest interactions can effectively dissipate a large fraction of the loading energy (>50%) under excessive compressions (over 80% strain, 1000 cycles) despite their high water contents (95%) under physiological conditions. No fatigue is observed in such highly swollen hydrogels during continuous cyclic compressions. We demonstrate that such hydrogels can be used as 3D cell carriers for excessive mechanical stimulation of the encapsulated stem cells, making them promising soft biomaterials for tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Multivalent Host–Guest Hydrogels as Fatigue-Resistant 3D Matrix for Excessive Mechanical Stimulation of Encapsulated Cells

Wei¹,

Chen²,

Li³

et al. 2017

Chem. Mater.

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“…33,34 Chemical copolymerization is a common approach to increase the crosslinking density to improve mechanical strength. [35][36][37] Specifically, the method is to add organic molecules such as acrylamide [38][39][40] and acrylic acid 41,42 to natural hydrogels to achieve copolymerization. However, these organic polymers either are non-degradable or lead to cytotoxic degradation products.…”

mentioning

confidence: 99%

3D-printable self-healing and mechanically reinforced hydrogels with host–guest non-covalent interactions integrated into covalently linked networks

et al. 2019

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“…41,42) Using a polymer carrying βCD as a solubilizing agent, ultraductile and stab resistant hydrogel was obtained. 43) …”

Section: Gel Formation Through Host-guest Interaction At Polymer Sidementioning

confidence: 99%

Supramolecular Polymeric Materials Containing Cyclodextrins

Nakahata

Takashima

Harada

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Smart design of polymeric materials may lead to intelligent materials exhibiting unique functional properties. Looking at nature, living systems use specific and reversible intermolecular interactions in realizing complex functions. Hence reversible bonds based on selective molecular recognition can impart artificial materials with unique functional properties. This review mainly focuses on supramolecular polymeric materials based on cyclodextrin-based host-guest interactions. Polymeric materials using molecular recognition at polymer main chain, side chain, and termini are described. Polymers carrying host and guest residues exhibit unique properties such as: 1) formation of macroscopic self-assembly of polymer gels carrying host and guest residues; 2) stimuli-responsive self-healing properties due to the reversible nature of host-guest interactions; and 3) macroscopic motion of artificial muscle cross-linked by host-guest interaction controlled by external stimuli. An overview of recent developments in this new frontier between materials science and life science is given.

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Ultraductile, notch and stab resistant supramolecular hydrogels via host–guest interactions

Abstract: We present a rational design based on a new host–guest strategy for fabrication of supramolecular hydrogels with a good combination of ultraductility, notch and stab resistance as well as self-healing behavior.

Cited by 24 publications

References 33 publications

Multivalent Host–Guest Hydrogels as Fatigue-Resistant 3D Matrix for Excessive Mechanical Stimulation of Encapsulated Cells

Multivalent Host–Guest Hydrogels as Fatigue-Resistant 3D Matrix for Excessive Mechanical Stimulation of Encapsulated Cells

3D-printable self-healing and mechanically reinforced hydrogels with host–guest non-covalent interactions integrated into covalently linked networks

Supramolecular Polymeric Materials Containing Cyclodextrins

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