Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications

Peng, Berney; Almeqdadi, Mohammad; Laroche, Fabrice; Palantavida, Shajesh; Dokukin, Maxim; Roper, Jatin; Yılmaz, Ömer H.; Feng, Hui; Sokolov, Igor

doi:10.1016/j.mattod.2018.11.001

Cited by 19 publications

(7 citation statements)

References 49 publications

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“…Owing to draping quality, and natural feeling, it is preferred as a fiber in textile product. Other using areas of cellulose acetate derivatives can be sorted as: cinema films, coating adhesive, plastic pipes, profile sheets, photographic films, cosmetics, pharmaceutics, medical membranes etc …”

Section: Introductionsupporting

confidence: 88%

Synthesis and Characterization of Cellulose Derivatives from Industrial Towel Waste

et al. 2019

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The paper covers the synthesis and characterization of cellulose derivatives from waste cellulose, namely, towel wastes. For this purpose, the cellulose acetate derivatives were synthesized from towel waste by applying the conventional chemical synthesis process. To clarify the structure of synthesized materials, some spectroscopic methods (FT-IR, XRD, 1 H-NMR, 13 C-NMR) were used. Furthermore, thermal behavior and surface morphology of prepared materials were investigated by DTG-TG and SEM, respectively. It was found that the degree of substitution values decreased as the duration of hydrolysis increased in cellulose diacetate synthesis. It was also understood that cellulose diacetate was dissolved in acetone differently from cellulose triacetate. Degree of substitution values of cellulose diacetate were compared by using 1 H-NMR and titrimetric method. These helped elucidate the expected reaction. The proposed method was easy compared with the conventional method.

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Section: Introductionsupporting

confidence: 88%

Synthesis and Characterization of Cellulose Derivatives from Industrial Towel Waste

et al. 2019

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“…injection and tested in zebrafish with MDA-MB-231-GFP cells subjected to TPE-PDT, showing decreased tumor growth after irradiation [ 132 ]. Moreover, with targeting purposes, Peng et al synthesized fluorescent cellulose acetate NPs functionalized with folate groups for their preferential accumulation in epithelial cancer cells overexpressing folic acid receptors [ 140 ]. These NPs can be tuned within the entire UV-VIS-NIR spectrum and were capable to target tumors in vivo.…”

Section: Preclinical Testing Of Nanoparticles Using Zebrafish Models Of Disease: Relevance Of Macrophagesmentioning

confidence: 99%

Zebrafish Models for the Safety and Therapeutic Testing of Nanoparticles with a Focus on Macrophages

et al. 2021

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New nanoparticles and biomaterials are increasingly being used in biomedical research for drug delivery, diagnostic applications, or vaccines, and they are also present in numerous commercial products, in the environment and workplaces. Thus, the evaluation of the safety and possible therapeutic application of these nanomaterials has become of foremost importance for the proper progress of nanotechnology. Due to economical and ethical issues, in vitro and in vivo methods are encouraged for the testing of new compounds and/or nanoparticles, however in vivo models are still needed. In this scenario, zebrafish (Danio rerio) has demonstrated potential for toxicological and pharmacological screenings. Zebrafish presents an innate immune system, from early developmental stages, with conserved macrophage phenotypes and functions with respect to humans. This fact, combined with the transparency of zebrafish, the availability of models with fluorescently labelled macrophages, as well as a broad variety of disease models offers great possibilities for the testing of new nanoparticles. Thus, with a particular focus on macrophage–nanoparticle interaction in vivo, here, we review the studies using zebrafish for toxicological and biodistribution testing of nanoparticles, and also the possibilities for their preclinical evaluation in various diseases, including cancer and autoimmune, neuroinflammatory, and infectious diseases.

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“…As such, CAs are widely used in coatings, cigarette filters, textile fibers, filtration membranes, and in a plethora of medical and pharmaceutical products. 12,13 Besides, CA can be used as a component in scaffolds and devices used in biomedical detection and imaging, 14 energy storage, 11 solar cells, 15 and sensing with recyclable optical fibers. 16 Despite the above-mentioned benefits, the inherent characteristics of CAFs still prevent their use when barrier and mechanical properties are demanded.…”

Section: ■ Introductionmentioning

confidence: 99%

Cross-Linked and Surface-Modified Cellulose Acetate as a Cover Layer for Paper-Based Electrochromic Devices

Kaschuk

Borghei

Solin

et al. 2021

ACS Appl. Polym. Mater.

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We studied the surface and microstructure of cellulose acetate (CA) films to tailor their barrier and mechanical properties for application in electrochromic devices (ECDs). Cross-linking of CA was carried out with pyromellitic dianhydride to enhance the properties relative to unmodified CA: solvent resistance (by 43% in acetone and 37% in DMSO), strength (by 91% for tensile at break), and barrier (by 65% to oxygen and 92% to water vapor). Surface modification via tetraethyl orthosilicate and octyltrichlorosilane endowed the films with hydrophobicity, stiffness, and further enhanced solvent resistance. A detailed comparison of structural, chemical, surface, and thermal properties was performed by using X-ray diffraction, dynamic mechanical analyses, Fourier-transform infrared spectroscopy, and atomic force microscopy. Coplanar ECDs were synthesized by incorporating a hydrogel electrolyte comprising TEMPO-oxidized cellulose nanofibrils and an ionic liquid. When applied as the top layer in the ECDs, cross-linked and hydrophobized CA films extended the functionality of the assembled displays. The results indicate excellent prospects for CA films in achieving environmental-friendly ECDs that can replace poly(ethylene terephthalate)-based counterparts.

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Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications

Cited by 19 publications

References 49 publications

Synthesis and Characterization of Cellulose Derivatives from Industrial Towel Waste

Synthesis and Characterization of Cellulose Derivatives from Industrial Towel Waste

Zebrafish Models for the Safety and Therapeutic Testing of Nanoparticles with a Focus on Macrophages

Cross-Linked and Surface-Modified Cellulose Acetate as a Cover Layer for Paper-Based Electrochromic Devices

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