The ever-growing demand for wireless communication services, coupled with the proliferation of diverse wireless devices, poses significant challenges related to spectrum efficiency and interference management. The specific features and technologies associated with 6G are still evolving, the overarching goals involve pushing the boundaries of wireless communication to meet the demands of future applications and services. This research aims to explore and advance the capabilities of smart spectrum sensing and wireless coexistence technologies to address these challenges. The study will focus on developing intelligent sensing mechanisms, adaptive spectrum allocation strategies, and cooperative coexistence protocols, with the goal of enhancing the overall performance, reliability, and coexistence of next-generation communication systems. This research contributes to the advancement of communication systems by addressing the pressing challenges of spectrum scarcity, interference, and coexistence. The proposed smart spectrum sensing and coexistence technologies have the potential to enhance the efficiency and reliability of next-generation wireless networks, fostering the deployment of emerging technologies such as 5G, IoT, and beyond.