Ultra-wide field imaging of pigmented para-venous retino-choroidal atrophy

Kumar, Vinod; Kumawat, Devesh; Tewari, Ruchir; Venkatesh, Pradeep

doi:10.1177/1120672118795056

Cited by 10 publications

(18 citation statements)

References 14 publications

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“…A crescent-like hyper-autofluorescent demarcation can be noticed at the border between the normal and affected retina or along the retinal veins, with or without central hypo-autofluorescence ( Fig. 5) [60]. Widefield OCTA revealed a relative sparing of the retinal capillary plexuses (superficial and deep), with diffuse defects in the choriocapillaris corresponding to RPE atrophy [61].…”

Section: Retinitis Pigmentosa and Pigmentary Dystrophiesmentioning

confidence: 98%

Reviewing the Role of Ultra-Widefield Imaging in Inherited Retinal Dystrophies

et al. 2020

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Inherited retinal dystrophies (IRD) are a heterogeneous group of rare chronic disorders caused by genetically determined degeneration of photoreceptors and retinal pigment epithelium cells. Ultra-widefield (UWF) imaging is a useful diagnostic tool for evaluating retinal integrity in IRD, including Stargardt disease, retinitis pigmentosa, cone dystrophies, and Best vitelliform dystrophy. Color or pseudocolor and fundus autofluorescence images obtained with UWF provide previously unavailable information on the retinal periphery, which correlates well with visual field measurement or electroretinogram. Despite unavoidable artifacts of the UWF device, the feasibility of investigations in infants and in patients with poor fixation makes UWF imaging a precious resource in the diagnostic armamentarium for IRD.

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Section: Retinitis Pigmentosa and Pigmentary Dystrophiesmentioning

confidence: 98%

Reviewing the Role of Ultra-Widefield Imaging in Inherited Retinal Dystrophies

et al. 2020

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“…These zones of hyper-AF may be found along peripheral veins and may precede frank RPE atrophy and pigment clumping. [196] Certain FAF patterns have been thought to be pathognomonic for certain RP genotypes. For example, a double concentric hyper-AF ring was first described in NR2E3-linked RP [197] and attributed to this mutation, but was thereafter also noted in USH2A-linked RP.…”

Section: Retinitis Pigmentosa (Rp)/rod-cone Dystrophiesmentioning

confidence: 99%

Fundus Autofluorescence and Clinical Applications

Pole

Ameri

2021

JOVR

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Fundus autofluorescence (FAF) has allowed in vivo mapping of retinal metabolic derangements and structural changes not possible with conventional color imaging. Incident light is absorbed by molecules in the fundus, which are excited and in turn emit photons of specific wavelengths that are captured and processed by a sensor to create a metabolic map of the fundus. Studies on the growing number of FAF platforms has shown each may be suited to certain clinical scenarios. Scanning laser ophthalmoscopes, fundus cameras, and modifications of these each have benefits and drawbacks that must be considered before and after imaging to properly interpret the images. Emerging clinical evidence has demonstrated the usefulness of FAF in diagnosis and management of an increasing number of chorioretinal conditions, such as agerelated macular degeneration, central serous chorioretinopathy, retinal drug toxicities, and inherited retinal degenerations such as retinitis pigmentosa and Stargardt disease. This article reviews commercial imaging platforms, imaging techniques, and clinical applications of FAF.

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“…Until now, the relevance of W-OCT imaging has predominantly been evaluated with respect to repeatability of measurements [9] ; normal retinal structures, especially the nerve fiber layer and choroidal layers [10][11][12][13][14][15][16][17] ; and glaucoma-associated pathologies [18][19][20][21][22] . Studies regarding retinal disorders focused on diabetic retinopathy [23][24][25][26][27] , central serous chorioretinopathy [28] , or alterations associated with myopia [29,30] , whereas retinal dystrophies have rarely been examined by W-OCT [31][32][33][34] and, if so, only in small patient series. When comparing these W-OCT studies, it has to be kept in mind that the terms "wide-field" and "ultra-wide-field" have been used for similar ranges of measured areas, and sometimes the measured area has not been reported and can only be surmised from the presented images.…”

Section: Introductionmentioning

confidence: 99%

Wide-field optical coherence tomography in ABCA4-associated inherited retinal dystrophies

Saleh¹,

Stöhr²,

Kiel³

et al. 2021

jtgg

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Aim: With a need to expand the monitoring options in therapeutic clinical trials, we evaluated the additional information provided by wide-field optical coherence tomography (W-OCT) compared to conventional macular volume scan OCT (M-OCT) in ABCA4 gene-associated inherited retinal dystrophies (ABCA4-IRD).Methods: A consecutive series of 52 ABCA4-IRD patients (mean age at last examination: 35.9 years, range 8.8-68.7 years) was examined between 2015 and 2021. Ophthalmologic examination included clinical examination, M-OCT [20 × 20 degree field (6.2 mm × 6.2 mm)], W-OCT [55 × 25 degree field (16.1 mm × 7.3 mm)], multicolor reflectance photography, fundus (FAF), and near-infrared autofluorescence (NIA) in macular and wide-field mode. Molecular genetic testing to confirm the clinical phenotype was performed in all patients. Conclusion:W-OCT as well as wide-field FAF and NIA document lesions in the retinal mid-and far periphery in the majority of ABCA4-IRD patients and provide means for detailed analysis of progression and future treatment planning and monitoring.

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Ultra-wide field imaging of pigmented para-venous retino-choroidal atrophy

Cited by 10 publications

References 14 publications

Reviewing the Role of Ultra-Widefield Imaging in Inherited Retinal Dystrophies

Reviewing the Role of Ultra-Widefield Imaging in Inherited Retinal Dystrophies

Fundus Autofluorescence and Clinical Applications

Wide-field optical coherence tomography in ABCA4-associated inherited retinal dystrophies

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